Chemical Safety Data Sheet MSDS / SDS
2,4-Dinitrotoluene
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: 2,4-Dinitrotoluene
- CBnumber: CB7852929
- CAS: 121-14-2
- EINECS Number: 204-450-0
- Synonyms: 1-methyl-2,4-dinitrobenzene;2,4-DINITROTOLUENE
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P201 Obtain special instructions before use.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
Hazard statements
H341 Suspected of causing genetic defects
H350 May cause cancer
H373 May cause damage to organs through prolonged or repeated exposure
H410 Very toxic to aquatic life with long lasting effects
Substance
- Product name: 2,4-Dinitrotoluene
- Synonyms: 1-methyl-2,4-dinitrobenzene;2,4-DINITROTOLUENE
- CAS: 121-14-2
- EC number: 204-450-0
- MF: C7H6N2O4
- MW: 182.13
General advice
First aiders need to protect themselves. Show this safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.
In case of eye contact
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
If swallowed
If swallowed: give water to drink (two glasses at most). Seek medical advice immediately. In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
Protection of first-aiders
For personal protection see section 8.
Notes to physician
No data available
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Water Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given. For this substance/mixture no limitations of extinguishing agents are given.
Specific hazards during fire fighting
Combustible. Vapours are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating. Development of hazardous combustion gases or vapours possible in the event of fire.
Hazardous combustion products
Carbon oxides Nitrogen oxides (NOx)
Specific extinguishing methods
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Special protective equipment for fire-fighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
NFPA 704
3
1
3
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 3 | Capable of detonation or explosive decomposition but requires a strong initiating source, must be heated under confinement before initiation, reacts explosively with water, or will detonate if severely shocked (e.g. ammonium nitrate, cesium, hydrogen peroxide) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid generation and inhalation of dusts in all circumstances. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of dusts.
Handling
Advice on safe handlingAvoid formation of dust and aerosols. Work under hood. Do not inhale substance/mixture.
Storage
Further information on storage conditionsTightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorised persons.
Storage class
6.1A, Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
Recommended storage temperature
Recommended storage temperature see product label.
Packaging material
Suitable material: Amber Glass Bottle/Jar
Ingredients with workplace control parameters
Contains no substances with occupational exposure limit values.
Engineering measures
No data available
Personal protective equipment
Respiratory protectionrequired when dusts are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Filter type P3
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Eye/face protection
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Safety glasses
Skin and body protection
Safety glasses
protective clothing
Hand protection
Material
Nitrile rubber
Break through time
480 min
Glove thickness
0.11 mm
Protective index
Full contact
Manufacturer
KCL 741 L
Material
Nitrile rubber
Break through time
480 min
Glove thickness
0.11 mm
Protective index
Splash contact
Manufacturer
KCL 741 L
Remarks
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D- 36124 Eichenzell, Internet: www.kcl.de).
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Information on basic physicochemical properties
- Henry's Law Constant5.39(x 10-8 atmm3/mol) at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999)
- SolubilitySoluble in acetone, ethanol, benzene, ether, and pyrimidine (Weast, 1986)
- Physical statesolid
- Particle characteristics Particle sizeNo data available
- Molecular weight182.13 g/mol
- Oxidizing propertiesnone
- Explosive propertiesNo data available
- Flow timeNo data available
- Viscosity, kinematicNo data available
- Viscosity, dynamicNo data available
- Decomposition temperature> 250 °C
- Autoignition temperature420 °C
- Partition coefficient: n-octanol/waterlog Pow: 1.98
Method Bioaccumulation is not expected. (IUCLID): (experimental) - Water solubility0.3 g/l (20 °C)
- Density1.52 g/cm3 (20 °C)
- Relative density1,521 g/cm3
- Relative vapor densityNo data available
- Vapor pressure133.3 hPa (157.7 °C) 1.3 hPa (102.7 °C)
- Lower explosion limit / Lower flammability limitNo data available
- Upper explosion limit / Upper flammability limitNo data available
- Burning rateNo data available
- Flammability (liquids)No data available
- Flammability (solid, gas)No data available
- Evaporation rateNo data available
- Flash point155.0 °C
Method: closed cup - Boiling point/boiling range300 °C (decomposition)
- Melting point/ range67 - 70 °C
- pHNo data available
- Odor ThresholdNo data available
- Odoraromatic
- Colorlight yellow dark yellow
- Appearancecrystalline
Reactivity
Forms explosive mixtures with air on intense heating. A range from approx. 15 Kelvin below the flash point is to be rated as critical. The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions
Violent reactions possible with: Oxidizing agents Reducing agents Strong bases Metals
Conditions to avoid
Strong heating.
Incompatible materials
No data available
Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityLD50 Oral - Rat - 268.0 mg/kg
Remarks: (RTECS)
Acute toxicity estimate Inhalation - 4 h - 0.51 mg/l - dust/mist
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Acute toxicity estimate Dermal - 300.1 mg/kg (Expert judgement)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Skin corrosion/irritation
Remarks: (RTECS)
Acute toxicity estimate Inhalation - 4 h - 0.51 mg/l - dust/mist
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Acute toxicity estimate Dermal - 300.1 mg/kg (Expert judgement)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Skin - Rabbit
Result: Mild skin irritation - 24 h
Remarks: (RTECS)
Serious eye damage/eye irritation
Result: Mild skin irritation - 24 h
Remarks: (RTECS)
Eyes - Rabbit
Result: No eye irritation
Remarks: (IUCLID)
Respiratory or skin sensitization
Result: No eye irritation
Remarks: (IUCLID)
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Suspected of causing genetic defects.
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Result: positive
Remarks: (National Toxicology Program)
Test Type: sister chromatid exchange assay
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Result: Positive results were obtained in some in vitro tests.
Remarks: (National Toxicology Program)
Carcinogenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Result: positive
Remarks: (National Toxicology Program)
Test Type: sister chromatid exchange assay
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Result: Positive results were obtained in some in vitro tests.
Remarks: (National Toxicology Program)
Presumed to have carcinogenic potential for humans
Reproductive toxicity
Suspected of damaging the unborn child.
Suspected of damaging fertility.
Specific target organ toxicity - single exposure
Suspected of damaging fertility.
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
May cause damage to organs through prolonged or repeated exposure.
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Aspiration hazard
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Classified based on available data. For more details, see section 2
11.2 Additional Information
RTECS: XT1575000
Absorption into the body leads to the formation of methemoglobin which in suffi- cient concentration causes cyanosis. Onset may be delayed 2 to 4 hours or longer.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Systemic effects:
Dizziness
Unconsciousness
Effect potentiated by: ethanol
Damage to:
Liver
Kidney
The following applies to aromatic nitro compounds in general: systemic effect: methaemoglobinaemia with headache, cardiac dysrhythmias, drop in blood pres- sure, dyspnoea, and spasms; principal sign: cyanosis (blue discolouration of the blood).
This substance should be handled with particular care.
Heart -
Absorption into the body leads to the formation of methemoglobin which in suffi- cient concentration causes cyanosis. Onset may be delayed 2 to 4 hours or longer.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Systemic effects:
Dizziness
Unconsciousness
Effect potentiated by: ethanol
Damage to:
Liver
Kidney
The following applies to aromatic nitro compounds in general: systemic effect: methaemoglobinaemia with headache, cardiac dysrhythmias, drop in blood pres- sure, dyspnoea, and spasms; principal sign: cyanosis (blue discolouration of the blood).
This substance should be handled with particular care.
Heart -
Ecotoxicity
Components:
2,4-dinitrotoluene:
Toxicity to fishLC50 (Pimephales promelas (fathead minnow)): 24.3 mg/l Exposure time: 96 h Test Type: flow-through test Analytical monitoring: yes Remarks: (ECOTOX Database)
Toxicity to daphnia and other aquatic invertebrates
EC50 (Daphnia magna (Water flea)): 26.2 mg/l Exposure time: 48 h Test Type: static test Remarks: (ECOTOX Database)
Toxicity to algae/aquatic plants
EC50 (Pseudokirchneriella subcapitata (green algae)): 1.6 mg/l Exposure time: 96 h Test Type: static test Remarks: (ECOTOX Database)
Toxicity to fish (Chronic toxicity)
NOEC (Oryzias latipes (Orange-red killifish)): 1 mg/l End point: Growth inhibition Exposure time: 28 d Remarks: (ECOTOX Database)
Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity)
NOEC (Daphnia magna (Water flea)): 3.2 mg/l Exposure time: 21 d Test Type: static test Remarks: (ECOTOX Database)
Ecotoxicology Assessment
Acute aquatic toxicityVery toxic to aquatic life.
Chronic aquatic toxicity
Very toxic to aquatic life with long lasting effects.
Persistence and degradability
Components:
2,4-dinitrotoluene:
Biodegradabilityaerobic Inoculum: activated sludge Result: Not biodegradable Biodegradation: 0 % Exposure time: 14 d Method: OECD Test Guideline 301C Remarks: (Lit.)
Bioaccumulative potential
Components:
2,4-dinitrotoluene:
Partition coefficient: noctanol/waterlog Pow: 1.98 Method: (experimental) Remarks: Bioaccumulation is not expected. (IUCLID)
Mobility in soil
No data available
Other adverse effects
Components:
2,4-dinitrotoluene:
Additional ecological informationDischarge into the environment must be avoided.
Disposal methods
Waste from residuesOffer surplus and non-recyclable solutions to a licensed disposal company.
International Regulations
IATA-DGR
UN/ID No. : UN 3454
Proper shipping name : Dinitrotoluenes, solid
Class : 6.1
Packing group : II
Labels : Division 6.1 - Toxic substances
Packing instruction (cargo aircraft) : 676
Packing instruction (passenger aircraft) : 669
Proper shipping name : Dinitrotoluenes, solid
Class : 6.1
Packing group : II
Labels : Division 6.1 - Toxic substances
Packing instruction (cargo aircraft) : 676
Packing instruction (passenger aircraft) : 669
IMDG-Code
UN number : UN 3454
Proper shipping name : DINITROTOLUENES, SOLID
Class : 6.1
Packing group : II
Labels : 6.1
EmS Code : F-A, S-A
Marine pollutant : yes
Proper shipping name : DINITROTOLUENES, SOLID
Class : 6.1
Packing group : II
Labels : 6.1
EmS Code : F-A, S-A
Marine pollutant : yes
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable for product as supplied.
National Regulations
JT/T 617
UN number : UN 3454
Proper shipping name : DINITROTOLUENES, SOLID
Class : 6.1
Packing group : II
Labels : 6.1
Environmentally hazardous : no
Proper shipping name : DINITROTOLUENES, SOLID
Class : 6.1
Packing group : II
Labels : 6.1
Environmentally hazardous : no
Special precautions for user
The transport classification(s) provided herein are for informational purposes only, and solely based upon the properties of the unpackaged material as it is described within this Safety Data Sheet. Transportation classifications may vary by mode of transportation, package sizes, and variations in regional or country regulations.
National regulatory information
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals
Listed
Identification of Major Hazard Installations for Hazardous Chemicals (GB 18218)
Not listed
Hazardous Chemicals for Priority Management
Not listed under SAWS
Catalogue of Specially Controlled Hazardous
Not listed Chemicals
List of Explosive Precursors
Listed
List of Toxic and Hazardous Soil Pollutants
Listed
Regulations on Labour Protection in Workplaces where Toxic Substances are Used
Catalogue of Highly Toxic Chemicals
Not listed
Regulation of Environmental Management on the First Import of Chemicals and the Import and Export of Toxic Chemicals
China Severely Restricted Toxic Chemicals for Import and Export
Not listed
Regulation on the Administration of Precursor Chemicals
Catalogue and Classification of Precursor Chemicals
Not listed
Regulations on the Administration of Controlled Chemicals
List of Controlled Chemicals
Not listed
Regulations of Ozone Depleting Substances Management
List of Controlled Ozone Depleting Substances
Not listed
List of Controlled Ozone Depleting Substances Import and Export
Not listed
Environmental Protection Law
List of Priority Controlled Chemicals
Listed
List of Key Controlled New Pollutants
Not listed
Full text of other abbreviations
AIIC - Australian Inventory of Industrial Chemicals
ANTT - National Agency forTransport by Land of Brazil
ASTM - American Society for the Testing of Materials
bw - Body weight
CMR - Carcinogen, Mutagen or Reproductive Toxicant
DIN -Standard of the German Institute for Standardisation
DSL - Domestic SubstancesList (Canada)
ECx - Concentration associated with x% response
ELx - Loading rate associated with x% response
EmS - Emergency Schedule
ENCS - Existing and NewChemical Substances (Japan)
ErCx - Concentration associated with x% growth rate response
ERG - Emergency Response Guide
GHS - Globally Harmonised System
GLP - Good Laboratory Practice
IARC - International Agency for Research on Can- cer
IATA - International Air Transport Association
IBC - International Code for theConstruction and Equipment of Ships carrying Dangerous Chemicals in Bulk
IC50 -Half maximal inhibitory concentration
ICAO - International Civil Aviation Organiza- tion
IECSC - Inventory of Existing Chemical Substances in China
IMDG - Interna- tional Maritime Dangerous Goods
IMO - International Maritime Organisation
ISHL -Industrial Safety and Health Law (Japan)
ISO - International Organisation forStandardisation
KECI - Korea Existing Chemicals Inventory
LC50 - Lethal Concen- tration to 50 % of a test population
LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose)
MARPOL - International Convention for the Prevention of Pol- lution from Ships
MERCOSUR - The Agreement for the Facilitation of the Transport of Dangerous Goods
n.o.s. - Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC - No Observed (Adverse) Effect Concentration
NO(A)EL - No Observed (Adverse) Ef- fect Level
NOELR - No Observable Effect Loading Rate
NOM - Official MexicanNorm
NTP - National Toxicology Program
NZIoC - New Zealand Inventory of Chem- icals
OECD - Organisation for Economic Co-operation and Development
OPPTS - Of- fice of Chemical Safety and Pollution Prevention
PBT - Persistent, Bioaccumulative and Toxic substance
PICCS - Philippines Inventory of Chemicals and Chemical Sub- stances
(Q)SAR - (Quantitative) Structure Activity Relationship
REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning theRegistration, Evaluation, Authorisation and Restriction of Chemicals
SADT - Self-Accelerating Decomposition Temperature
SDS - Safety Data Sheet
TCSI - TaiwanChemical Substance Inventory
TDG - Transportation of Dangerous Goods
TECI -Thailand Existing Chemicals Inventory
TSCA - Toxic Substances Control Act (UnitedStates)
UN - United Nations
UNRTDG - United Nations Recommendations on theTransport of Dangerous Goods
vPvB - Very Persistent and Very Bioaccumulative
WHMIS - Workplace Hazardous Materials Information System
ANTT - National Agency forTransport by Land of Brazil
ASTM - American Society for the Testing of Materials
bw - Body weight
CMR - Carcinogen, Mutagen or Reproductive Toxicant
DIN -Standard of the German Institute for Standardisation
DSL - Domestic SubstancesList (Canada)
ECx - Concentration associated with x% response
ELx - Loading rate associated with x% response
EmS - Emergency Schedule
ENCS - Existing and NewChemical Substances (Japan)
ErCx - Concentration associated with x% growth rate response
ERG - Emergency Response Guide
GHS - Globally Harmonised System
GLP - Good Laboratory Practice
IARC - International Agency for Research on Can- cer
IATA - International Air Transport Association
IBC - International Code for theConstruction and Equipment of Ships carrying Dangerous Chemicals in Bulk
IC50 -Half maximal inhibitory concentration
ICAO - International Civil Aviation Organiza- tion
IECSC - Inventory of Existing Chemical Substances in China
IMDG - Interna- tional Maritime Dangerous Goods
IMO - International Maritime Organisation
ISHL -Industrial Safety and Health Law (Japan)
ISO - International Organisation forStandardisation
KECI - Korea Existing Chemicals Inventory
LC50 - Lethal Concen- tration to 50 % of a test population
LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose)
MARPOL - International Convention for the Prevention of Pol- lution from Ships
MERCOSUR - The Agreement for the Facilitation of the Transport of Dangerous Goods
n.o.s. - Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC - No Observed (Adverse) Effect Concentration
NO(A)EL - No Observed (Adverse) Ef- fect Level
NOELR - No Observable Effect Loading Rate
NOM - Official MexicanNorm
NTP - National Toxicology Program
NZIoC - New Zealand Inventory of Chem- icals
OECD - Organisation for Economic Co-operation and Development
OPPTS - Of- fice of Chemical Safety and Pollution Prevention
PBT - Persistent, Bioaccumulative and Toxic substance
PICCS - Philippines Inventory of Chemicals and Chemical Sub- stances
(Q)SAR - (Quantitative) Structure Activity Relationship
REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning theRegistration, Evaluation, Authorisation and Restriction of Chemicals
SADT - Self-Accelerating Decomposition Temperature
SDS - Safety Data Sheet
TCSI - TaiwanChemical Substance Inventory
TDG - Transportation of Dangerous Goods
TECI -Thailand Existing Chemicals Inventory
TSCA - Toxic Substances Control Act (UnitedStates)
UN - United Nations
UNRTDG - United Nations Recommendations on theTransport of Dangerous Goods
vPvB - Very Persistent and Very Bioaccumulative
WHMIS - Workplace Hazardous Materials Information System
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.