4,4'-Methylenedianiline

Skin sensitization, Category 1

Germ cell mutagenicity, Category 2

Carcinogenicity, Category 1B

Specific target organ toxicity – single exposure, Category 1

Specific target organ toxicity – repeated exposure, Category 2

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

H302 Harmful if swallowed

H317 May cause an allergic skin reaction

H341 Suspected of causing genetic defects

H350 May cause cancer

H370 Causes damage to organs

H373 May cause damage to organs through prolonged or repeated exposure

H401 Toxic to aquatic life

H411 Toxic to aquatic life with long lasting effects

P201 Obtain special instructions before use.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P273 Avoid release to the environment.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313 IF exposed or concerned: Get medical advice/attention.

P405 Store locked up.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P203 Obtain, read and follow all safety instructions before use.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P273 Avoid release to the environment.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P333+P317 If skin irritation or rash occurs: Get medical help.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P318 IF exposed or concerned, get medical advice.

P308+P316 IF exposed or concerned: Get emergency medical help immediately.

P319 Get medical help if you feel unwell.

P391 Collect spillage.

P405 Store locked up.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Refer for medical attention .

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Nitrates, nitrites, and related compounds

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: SMALL FIRE: Dry chemical, CO2 or water spray. LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal; do not scatter the material. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. (ERG, 2016)

Use water spray, powder, foam, carbon dioxide.

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Facility and process are discussed for removal of methylenedianiline.

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from strong oxidants and food and feedstuffs. Well closed. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMPOSE INTO TOXIC COMPONENTS...SHOULD BE STORED IN A COOL WELL VENTILATED PLACE, OUT OF THE DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, & SHOULD BE PERIODICALLY INSPECTED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED...

TLV: 0.1 ppm as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans).MAK: skin absorption (H); sensitization of skin (SH); carcinogen category: 2

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear safety spectacles or face shield.

Protective gloves. Protective clothing.

Use ventilation (not if powder), local exhaust or breathing protection.

no data available

NIOSH considers 4,4'-methylenedianiline be a potential occupational carcinogen.

The substance is a weak base. Reacts violently with strong oxidants.

Oxidizes in air; pale yellow crystals turn dark color when exposed to air.

Combustable when exposed to hear or flame.4,4'-DIAMINODIPHENYLMETHANE polymerizes if heated above 257° F. Incompatible with strong oxidizing agents. It is also incompatible with acids. Catalyzes isocyanate-alcohol and epoxide reactions. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

no data available

Strong oxidizers.

When heated to decomposition it emits highly toxic fumes of aniline and NOx.

no data available

no data available

no data available

no data available

No data are available in humans. Sufficient evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 2B: The agent is possibly carcinogenic to humans.

No adequate information is available on the reproductive or developmental effects of MDA in humans or animals.

The substance may cause effects on the liver. This may result in liver impairment.

Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the liver. This substance is possibly carcinogenic to humans.

A harmful concentration of airborne particles can be reached quickly when dispersed.

AEROBIC: 4,4'-Diaminodiphenylmethane, present at 100 mg/L, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). Aerobic biodegradation of 4,4'-diaminodiphenylmethane in a silt loam soil (measured as the fraction of CO2 recovered) was 2, 10, 11.2, and 11.6% after 3, 14, 28, and 56 days, respectively(2). Apparent biodegradation after 365 days in the silt loam soil was reported as 40.1%(2).

BCF values ranging from 3.0 to 14 were measured for 4,4'-diaminodiphenylmethane (200 ug/L) in carp (4.5% lipid content) after a 6 week period(1). According to a classification scheme(2), these BCF values suggest the bioconcentration in aquatic organisms is low(SRC).

After an 8 hour sorption period, Koc values of 5681 and 3825 were measured for 4,4'-diaminodiphenylmethane in sandy loam under aerobic and anaerobic conditions, respectively(1). Koc values of 4015 and 3831 were measured in silt loam under aerobic and anaerobic conditions, respectively(1). According to a classification scheme(2), these measured Koc values suggest that 4,4'-diaminodiphenylmethane is expected to have slight to no mobility in soil. The reaction of 4,4'-diaminodiphenylmethane with soil humics was studied by allowing the substance to remain in contact with soil for 7 days and then measuring desorption in 1 day. The results suggested that 4,4'-diaminodiphenylmethane sorbed onto soil may be in a relatively facile equilibrium with the surrounding solution as shown by the similarity of distribution ratios (sorbed compound (in ug/g of soil)/concentrated in solution (in ug/mL)) for both sorption and desorption with Rdesorb/Rsorb ranging from 1.1 to 1.4(1). In this study the average ratio of aerobic/anaerobic soil sorption coefficients for 4,4'-diaminodiphenylmethane was 1.27, suggesting little difference between the behavior of 4,4'-diaminodiphenylmethane with soil under oxidizing and reducing conditions(1). Aromatic amines have been observed to undergo rapid and reversible covalent bonding with humic materials in aqueous solution; the initial bonding reaction is followed by a slower and much less reversible reaction believed to represent the addition of the amine to quinoidal structures followed by oxidation of the product to give an amino-substituted quinone; these processes represent pathways by which aromatic amines may be converted to latent forms in the biosphere(3).

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN2651 (For reference only, please check.)

IMDG: UN2651 (For reference only, please check.)

IATA: UN2651 (For reference only, please check.)

ADR/RID: 4,4'-DIAMINODIPHENYL- METHANE (For reference only, please check.)

IMDG: 4,4'-DIAMINODIPHENYL- METHANE (For reference only, please check.)

IATA: 4,4'-DIAMINODIPHENYL- METHANE (For reference only, please check.)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

ADR/RID: III (For reference only, please check.)

IMDG: III (For reference only, please check.)

IATA: III (For reference only, please check.)

ADR/RID: Yes

IMDG: Yes

IATA: Yes

no data available

no data available

Do NOT take working clothes home.Depending on the degree of exposure, periodic medical examination is suggested.