Chemical Safety Data Sheet MSDS / SDS
4-Nitrophenol
Revision Date:2026-04-04Revision Number:1
Product identifier
- Product name: 4-Nitrophenol
- CBnumber: CB7852550
- CAS: 100-02-7
- EINECS Number: 202-811-7
- Synonyms: 4-nitrophenol,p-Nitrophenol
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
P314 Get medical advice/attention if you feel unwell.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Hazard statements
H373 May cause damage to organs through prolonged or repeated exposure
Substance
- Product name: 4-Nitrophenol
- Synonyms: 4-nitrophenol,p-Nitrophenol
- CAS: 100-02-7
- EC number: 202-811-7
- MF: C6H5NO3
- MW: 139.11
General Advice
Show this safety data sheet to the doctor in attendance. Immediate medical attention is required.
Eye Contact
In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Skin Contact
Wash off immediately with plenty of water for at least 15 minutes. Immediate medical attention is required.
Inhalation
Remove to fresh air. If not breathing, give artificial respiration. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Immediate medical attention is required.
Ingestion
Call a physician or poison control center immediately. Do NOT induce vomiting.
Most important symptoms and effects
None reasonably foreseeable.
Self-Protection of the First Aider
Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and prevent spread of contamination.
Notes to Physician
Treat symptomatically.
Suitable Extinguishing Media
Water spray, carbon dioxide (CO2), dry chemical, alcohol-resistant foam. Water mist may be used to cool closed containers.
Extinguishing media which must not be used for safety reasons
No information available.
Specific Hazards Arising from the Chemical
Fine dust dispersed in air may ignite. Dust can form an explosive mixture with air. Thermal decomposition can lead to release of irritating gases and vapors. Keep product and empty container away from heat and sources of ignition.
Protective Equipment and Precautions for Firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Thermal decomposition can lead to release of irritating gases and vapors.
NFPA 704
3
1
2
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 2 | Undergoes violent chemical change at elevated temperatures and pressures, reacts violently with water, or may form explosive mixtures with water (e.g. white phosphorus, potassium, sodium) | |
| SPEC. HAZ. |
Personal Precautions
Use personal protective equipment as required. Ensure adequate ventilation. Avoid dust formation. Keep people away from and upwind of spill/leak. Evacuate personnel to safe areas.
Environmental Precautions
Do not flush into surface water or sanitary sewer system. See Section 12 for additional Ecological Information. Avoid release to the environment. Collect spillage.
Methods for Containment and Clean Up
Sweep up and shovel into suitable containers for disposal. Avoid dust formation.
Refer to protective measures listed in Sections 8 and 13.
Refer to protective measures listed in Sections 8 and 13.
Handling
Wear personal protective equipment/face protection. Avoid dust formation. Do not get in eyes, on skin, or on clothing. Use only under a chemical fume hood. Do not breathe (dust, vapor, mist, gas). Do not ingest. If swallowed then seek immediate medical assistance.
Storage
Keep containers tightly closed in a dry, cool and well-ventilated place. Protect from direct sunlight.
Specific Use(s)
Use in laboratories
Control Parameters
Monitoring methods
BS EN 14042:2003 Title Identifier: Workplace atmospheres. Guide for the application and use of procedures for the assessment of exposure to chemical and biological agents. MDHS14/3 General methods for sampling and gravimetric analysis of respirable and inhalable dust
Exposure Controls
Engineering Measures
Use only under a chemical fume hood. Ensure that eyewash stations and safety showers are close to the workstation location.
Wherever possible, engineering control measures such as the isolation or enclosure of the process, the introduction of process or equipment changes to minimise release or contact, and the use of properly designed ventilation systems, should be adopted to control hazardous materials at source.
Wherever possible, engineering control measures such as the isolation or enclosure of the process, the introduction of process or equipment changes to minimise release or contact, and the use of properly designed ventilation systems, should be adopted to control hazardous materials at source.
Personal protective equipment
Eye ProtectionGoggles (European standard - EN 166)
Hand Protection
Protective gloves
Inspect gloves before use.
Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion.
Remove gloves with care avoiding skin contamination.
Skin and body protection
| Glove material | Breakthrough time | Glove thickness | EU standard | Glove comments |
|---|---|---|---|---|
| Natural rubber | See manufacturers | - | EN 374 | (minimum requirement) |
| Nitrile rubber | recommendations | |||
| Neoprene | ||||
| PVC |
Inspect gloves before use.
Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion.
Remove gloves with care avoiding skin contamination.
Long sleeved clothing
Respiratory Protection
When workers are facing concentrations above the exposure limit they must use appropriate certified respirators.
To protect the wearer, respiratory protective equipment must be the correct fit and be used and maintained properly
Large scale/emergency use
To protect the wearer, respiratory protective equipment must be the correct fit and be used and maintained properly
Use a NIOSH/MSHA or European Standard EN 136 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced
Recommended Filter type: Particulates filter conforming to EN 143
Small scale/Laboratory use
Recommended Filter type: Particulates filter conforming to EN 143
Use a NIOSH/MSHA or European Standard EN 149:2001 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Recommended half mask:- Particle filtering: EN149:2001
When RPE is used a face piece Fit Test should be conducted
Recommended half mask:- Particle filtering: EN149:2001
When RPE is used a face piece Fit Test should be conducted
Hygiene Measures
Handle in accordance with good industrial hygiene and safety practice.
Environmental exposure controls
Prevent product from entering drains. Do not allow material to contaminate ground water system.
Information on basic physicochemical properties
- ColourYellow to brown
- Henry's Law Constant1.63 x 10-7 at 5 °C (average derived from six field experiments, Lüttke and Levsen, 1997)
- Molecular Weight139.11
- Molecular FormulaC6 H5 N O3
- Oxidizing PropertiesNo information available
- Explosive PropertiesNo information available
- ViscosityNot applicable Solid
- Decomposition Temperature279 °C
- Autoignition Temperature283 °C / 541.4 °F
- desc_infoComponent: p-Nitrophenol log Pow: 1.95
- Partition Coefficient (n-octanol/water)No data available
- Solubility in other solventsethanol: soluble95%, clear, dark yellow (100 mg/mL)
- Water Solubility1.6g/100ml (25°C)
- Bulk Density1,27 g/cm3
- Specific Gravity / Density1,27 g/cm3
- Vapor DensityNot applicable Solid
- Vapor Pressure0.6 mm Hg ( 120 °C)
- Explosion LimitsNo data available
- Flammability (solid,gas)No information available
- Evaporation RateNot applicable Solid
- Flash Point169 °C / 336.2 °F Method - No information available
- Boiling Point/Range279 °C / 534.2 °
F @ 760 mmHg - Softening PointNo data available
- Melting Point/Range> 112 °C / 233.6 °F
- pH4.4 5 g/l aq.sol
- Odor ThresholdNo data available
- Odoraromatic
- Physical StateSolid
- AppearanceBrown
Stability
Light sensitive.
Hazardous Reactions
None under normal processing.
Hazardous Polymerization
Hazardous polymerization does not occur.
Conditions to Avoid
Avoid dust formation. Incompatible products. Heat, flames and sparks. Temperatures above 75°C. Exposure to light.
Materials to avoid
Strong oxidizing agents. Strong bases. Combustible material.
Hazardous Decomposition Products
Nitrogen oxides (NOx). Carbon monoxide (CO). Carbon dioxide (CO2).
Product Information
(a) acute toxicity;
| Component | LD50 Oral | LD50 Dermal | LC50 Inhalation |
|---|---|---|---|
| p-Nitrophenol | LD50 = 202 mg/kg ( Rat ) | LD50 = 1024 mg/kg ( Rat ) | LC50 > 4.7 mg/L ( Rat ) 4 h |
(b) skin corrosion/irritation;
No data available
(c) serious eye damage/irritation;
No data available
(d) respiratory or skin sensitization;
Respiratory
No data available
Skin
No data available
(e) germ cell mutagenicity;
No data available
Not mutagenic in AMES Test
Not mutagenic in AMES Test
(f) carcinogenicity;
No data available
There are no known carcinogenic chemicals in this product
There are no known carcinogenic chemicals in this product
(g) reproductive toxicity;
No data available
(h) STOT-single exposure;
No data available
(i) STOT-repeated exposure;
No data available
Route of exposure
Oral
Target Organs
Liver, Kidney.
(j) aspiration hazard;
Not applicable
Solid
Solid
Symptoms / effects,both acute and delayed
No information available
Ecotoxicity effects
The product contains following substances which are hazardous for the environment.
Contains a substance which is: . Harmful to aquatic organisms.
Contains a substance which is: . Harmful to aquatic organisms.
| Component | Freshwater Fish | Water Flea | Freshwater Algae | Microtox |
|---|---|---|---|---|
| p-Nitrophenol | LC50: = 10.4 mg/L, 96h static (Brachydanio rerio) LC50: = 14 mg/L, 96h static (Poecilia reticulata) LC50: = 30.4 mg/L, 96h flow-through (Pimephales promelas) | EC50: 22 mg/L, 48h (Daphnia magna), OECD 202 | EC50: = 23.7 mg/L, 96h (Desmodesmus subspicatus) | EC50 = 13 mg/L 30 min EC50 = 5.5 mg/L 24 h |
Persistence and Degradability
Readily biodegradable
Persistence
Persistence is unlikely.
Degradation in sewage
Contains substances known to be hazardous to the environment or not degradable in waste
treatment plant
water treatment plants.
Bioaccumulative Potential
Bioaccumulation is unlikely
| Component | log Pow | Bioconcentration factor (BCF) |
|---|---|---|
| p-Nitrophenol | 1.95 | No data available |
Mobility in soil
The product is water soluble, and may spread in water systems Will likely be mobile in the environment due to its water solubility Highly mobile in soils
Endocrine Disruptor Information
This product does not contain any known or suspected endocrine disruptors
Persistent Organic Pollutant
This product does not contain any known or suspected substance
Ozone Depletion Potential
This product does not contain any known or suspected substance
Waste from Residues/Unused Products
Waste is classified as hazardous. Dispose of in accordance with the European Directives on waste and hazardous waste. Dispose of in accordance with local regulations.
Contaminated Packaging
Dispose of this container to hazardous or special waste collection point.
Other Information
Do not flush to sewer. Waste codes should be assigned by the user based on the application for which the product was used. Do not empty into drains.
Road and Rail Transport
UN-NoUN1663
Proper Shipping Name
NITROPHENOLS
Hazard Class
6.1
Packing Group
III
IMDG/IMO
UN-NoUN1663
Proper Shipping Name
NITROPHENOLS
Hazard Class
6.1
Packing Group
III
IATA
UN-NoUN1663
Proper Shipping Name
NITROPHENOLS
Hazard Class
6.1
Packing Group
III
Special Precautions for User
No special precautions required
International Inventories
X = listed, China (IECSC), Europe (EINECS/ELINCS/NLP), U.S.A. (TSCA), Canada (DSL/NDSL), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), Korea (KECL).
| Component | The Inventory of Hazardous Chemicals (2015 Edition) | List of dangerous goods GB 12268 - 2012 | TCSI | IECSC | EINECS | TSCA | DSL | PICCS | ENCS | ISHL | AICS | KECL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| p-Nitrophenol | X | - | X | X | 202-811-7 | X | X | X | X | X | X | KE-26012 |
National Regulations
Prepared By
Health, Safety and Environmental Department
Creation Date
06-Feb-2015
Revision Date
18-Sep-2025
Revision Summary
SDS sections updated.
Training Advice
Chemical hazard awareness training, incorporating labelling, Safety Data Sheets (SDS), Personal Protective Equipment (PPE) and hygiene.
Use of personal protective equipment, covering appropriate selection, compatibility, breakthrough thresholds, care, maintenance, fit and standards.
First aid for chemical exposure, including the use of eye wash and safety showers.
Use of personal protective equipment, covering appropriate selection, compatibility, breakthrough thresholds, care, maintenance, fit and standards.
First aid for chemical exposure, including the use of eye wash and safety showers.
Legend
CASChemical Abstracts Service
TSCA
United States Toxic Substances Control Act Section 8(b)
Inventory
EINECS/ELINCS
Inventory
European Inventory of Existing Commercial Chemical
Substances/EU List of Notified Chemical Substances
DSL/NDSL
Substances/EU List of Notified Chemical Substances
Canadian Domestic Substances List/Non-Domestic
Substances List
PICCS
Substances List
Philippines Inventory of Chemicals and Chemical Substances
ENCS
Japanese Existing and New Chemical Substances
IECSC
Chinese Inventory of Existing Chemical Substances
AICS
Australian Inventory of Chemical Substances
KECL
Korean Existing and Evaluated Chemical Substances
NZIoC
New Zealand Inventory of Chemicals
WEL
Workplace Exposure Limit
TWA
Time Weighted Average
ACGIH
American Conference of Governmental Industrial Hygienists
IARC
International Agency for Research on Cancer
DNEL
Derived No Effect Level
PNEC
Predicted No Effect Concentration
RPE
Respiratory Protective Equipment
LD50
Lethal Dose 50%
LC50
Lethal Concentration 50%
EC50
Effective Concentration 50%
NOEC
No Observed Effect Concentration
POW
Partition coefficient Octanol:Water
PBT
Persistent, Bioaccumulative, Toxic
vPvB
very Persistent, very Bioaccumulative
ICAO/IATA
International Civil Aviation Organization/International Air
Transport Association
IMO/IMDG
Transport Association
International Maritime Organization/International Maritime
Dangerous Goods Code
ADR
Dangerous Goods Code
European Agreement Concerning the International Carriage of
Dangerous Goods by Road
MARPOL
Dangerous Goods by Road
International Convention for the Prevention of Pollution from
Ships
OECD
Ships
Organisation for Economic Co-operation and Development
ATE
Acute Toxicity Estimate
BCF
Bioconcentration factor
VOC
(Volatile Organic Compound)
Key literature references and sources for data
https://echa.europa.eu/information-on-chemicals
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.