11.1 Information on toxicological effects
Mixture Acute toxicity
Oral: No data available
Acute toxicity estimate Oral - 3,425 mg/kg (Calculation method)
Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the esophagus and the stomach.
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract
Dermal: No data available
Skin corrosion/irritation
Remarks: Causes burns.
Serious eye damage/eye irritation
Remarks: Risk of serious damage to eyes.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache,
Nausea, Vomiting, Ingestion or inhalation of concentrated acetic acid causes dam- age to tissues of the respiratory and digestive tracts. Symptoms include: hema- temesis, bloody diarrhea, edema and/or perforation of the esophagus and pylorus, pancreatitis, hematuria, anuria, uremia, albuminuria, hemolysis, convulsions, bron- chitis, pulmonary edema, pneumonia, cardiovascular collapse, shock, and death.
Direct contact or exposure to high concentrations of vapor with skin or eyes can cause: erythema, blisters, tissue destruction with slow healing, skin blackening, hyperkeratosis, fissures, corneal erosion, opacification, iritis, conjunctivitis, and possible blindness., To the best of our knowledge, the chemical, physical, and toxi- cological properties have not been thoroughly investigated.
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Components acetic acid
Acute toxicity
LD50 Oral - Rat - 3,310 mg/kg
Remarks: (RTECS)
LC50 Inhalation - Mouse - 4 h - 2,819 mg/l - vapor
Remarks: (RTECS)
Dermal: No data available
Skin corrosion/irritation
Skin - Rabbit
Result: Causes burns. - 4 h (OECD Test Guideline 404)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Causes burns. - 4 h (OECD Test Guideline 405)
Remarks: (IUCLID)
Remarks: Causes serious eye damage.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Result: negative
Method: Mutagenicity (micronucleus test)
Species: Rat - male and female - Bone marrow
Result: negative
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
Hydrochloric Acid Acute toxicity
Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the esophagus and the stomach.
Inhalation: Cough Difficulty in breathing
Symptoms: mucosal irritations, Cough, Shortness of breath, Inhalation may lead to the formation of oedemas in the respiratory tract., Possible damag- es:, damage of respiratory tract, tissue damage
Dermal: No data available
Skin corrosion/irritation
Skin - reconstructed human epidermis (RhE)
Result: Corrosive (OECD Test Guideline 431)
Serious eye damage/eye irritation
Eyes - Bovine cornea
Result: Causes serious eye damage. - 10 min (OECD Test Guideline 437)
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: negative (OECD Test Guideline 406)
Germ cell mutagenicity
Test Type: Chromosome aberration test in vitro
Test system: Chinese hamster ovary cells
Result: Positive results were obtained in some in vitro tests.
Remarks: (ECHA)
Test Type: mitotic recombination assay
Test system: Saccharomyces cerevisiae
Result: negative
Remarks: (ECHA)
Test Type: Ames test
Test system: mouse lymphoma cells
Result: positive
Remarks: (ECHA)
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
May cause respiratory irritation. - Respiratory system
Acute oral toxicity - If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the esophagus and the stomach.
Acute inhalation toxicity - mucosal irritations, Cough, Shortness of breath,
Inhalation may lead to the formation of oedemas in the respiratory tract.,
Possible damages:, damage of respiratory tract, tissue damage
Specific target organ toxicity - repeated exposure
The substance or mixture is not classified as specific target organ toxicant, repeated exposure.
Aspiration hazard
No aspiration toxicity classification