Chemical Safety Data Sheet MSDS / SDS

Choline chloride

Revision Date:2024-04-13Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: Choline chloride
  • CBnumber: CB6166667
  • CAS: 67-48-1
  • EINECS Number: 200-655-4
  • Synonyms: choline chloride,Choline Chloride pure

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 400-158-6606

SECTION 2: Hazards identification

Classification of the substance or mixture

Not classified.

Label elements

Pictogram(s)
  • Signal wordWarning
Hazard statement(s)

H303 May be harmfulif swallowed

H315 Causes skin irritation

H319 Causes serious eye irritation

H335 May cause respiratory irritation

Precautionary statement(s)

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P264 Wash hands thoroughly after handling.

P264 Wash skin thouroughly after handling.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405 Store locked up.

Prevention

none

Response

none

Storage

none

Disposal

none

Other hazards

no data available

SECTION 3: Composition/information on ingredients

Substance

  • Product name: Choline chloride
  • Synonyms: choline chloride,Choline Chloride pure
  • CAS: 67-48-1
  • EC number: 200-655-4
  • MF: C5H14ClNO
  • MW: 139.62

SECTION 4: First aid measures

Description of first aid measures

If inhaled

Fresh air, rest.

Following skin contact

Rinse and then wash skin with water and soap.

Following eye contact

Rinse with plenty of water for several minutes (remove contact lenses if easily possible).

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Most important symptoms and effects, both acute and delayed

no data available

Indication of any immediate medical attention and special treatment needed

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Poisons A and B

SECTION 5: Firefighting measures

Extinguishing media

To fight fires involving this chemical, you should be equipped with an air line or self-contained breathing apparatus. Extinguish with a dry chemical, carbon dioxide, foam or halon extinguisher. (NTP, 1992)

Specific Hazards Arising from the Chemical

This chemical is relatively nonflammable. (NTP, 1992)

Advice for firefighters

Use water spray, powder.

NFPA 704

0
1
1
HEALTH 0 Poses no health hazard, no precautions necessary and would offer no hazard beyond that of ordinary combustible materials
FIRE 1 Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
REACT 1 Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.

Environmental precautions

Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.

Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

SECTION 7: Handling and storage

Precautions for safe handling

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from strong oxidants.

SECTION 8: Exposure controls/personal protection

Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

Exposure controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Individual protection measures

Eye/face protection

Wear safety spectacles.

Skin protection

Protective gloves.

Respiratory protection

Use ventilation.

Thermal hazards

no data available

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • Physical stateAdhering Crystals
  • ColourWhite
  • Odour

    no data available

  • Melting point/freezing point

    Ca. 200 °C. Atm. press.:Ca. 1 013 mBar. Remarks:First signs of an exothermal reaction were denoted at 110°C, the maximum of this reaction was at 200°C.

  • Boiling point or initial boiling point and boiling range

    Ca. 300 °C. Atm. press.:Ca. 1 013 mBar. Remarks:First signs of an subsequent reaction were denoted at 250°C, the maximum of this reaction was at 300°C. However, the nature of the test method does not allow to differentiate between boiling and decomposition temperature.

  • Flammability

    Combustible. Gives off irritating or toxic fumes (or gases) in a fire.

  • Lower and upper explosion limit/flammability limit

    no data available

  • Flash point

    60°C(lit.)

  • Auto-ignition temperature

    330 °C. Remarks:No further details available.

  • Decomposition temperature

    no data available

  • pH5.0-7.5 (25℃, 1M in H2O)
  • Kinematic viscosity

    dynamic viscosity (in mPa s) = 26.2. Temperature:20°C. Remarks:At 20°C, the behaviour of the test substance was found to be Newtonian over the measured shear range of 10 to 200 1/s.;dynamic viscosity (in mPa s) = 14.1. Temperature:40°C. Remarks:At 40°C, the behaviour of the test substance was found to be Newtonian over the measured shear range of 10 to 200 1/s.

  • SolubilityH2O: 1 M, clear, colorless
  • Partition coefficient n-octanol/water

    Pow = 0. Temperature:25 °C. Remarks:Average of three independent determinations.;log Pow = -3.77. Temperature:25 °C. Remarks:Average of three independent determinations.

  • Vapour pressure

    0 Pa. Temperature:25 °C. Remarks:Modified Grain Method (MPBPWIN v1.43), calculated for pure choline chloride.;2 287.2 Pa. Temperature:25 °C. Remarks:Modified Grain Method (MPBPWIN v1.43), calculated for 75% aqueous solution of choline chloride.

  • Density and/or relative density

    1.1 g/cm3. Temperature:20 °C.

  • Relative vapour density

    no data available

  • Particle characteristics

    no data available

SECTION 10: Stability and reactivity

Reactivity

On combustion, forms toxic and corrosive fumes including hydrogen chloride. Reacts with strong oxidants.

Chemical stability

Keep tightly closed.

Possibility of hazardous reactions

Choline chloride is a quaternary ammonium salt. Quaternary ammonium salts often serve as catalysts in reactions. They are incompatible with many strong oxidizers and reducing agents, such as metal hydrides, alkali/active metals, and organometallics. Quaternary ammonium salts often serve as catalysts in reactions. They are incompatible with many strong oxidizers and reducing agents, such as metal hydrides, alkali/active metals, and organometallics. Unlike the ammonium ion, [NH4]+, and the primary, secondary, or tertiary ammonium cations, the quaternary ammonium cations are permanently charged, independent of the pH of their solution.

Conditions to avoid

no data available

Incompatible materials

no data available

Hazardous decomposition products

When heated to decomposition it emits toxic fumes of chloride, /sulfur oxides/, and /Nitrogen oxides/.

SECTION 11: Toxicological information

Acute toxicity

  • Oral: LD0 - rat - >= 2 790 mg/kg bw. Remarks:Given on three consecutive days, hence LD0 can be calculated as intermittent total dose to 8.37 g/kg bw.
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

A nuisance-causing concentration of airborne particles can be reached quickly when dispersed.

SECTION 12: Ecological information

Toxicity

  • Toxicity to fish: LC50 - Leuciscus idus - > 10 000 mg/L - 96 h.
  • Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 500 mg/L - 48 h.
  • Toxicity to algae: EC50 - Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) - > 500 mg/L - 72 h.
  • Toxicity to microorganisms: EC10 - Pseudomonas putida - 112.9 mg/L - 17 h.

Persistence and degradability

no data available

Bioaccumulative potential

no data available

Mobility in soil

no data available

Other adverse effects

no data available

SECTION 13: Disposal considerations

Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

SECTION 14: Transport information

UN Number

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

UN Proper Shipping Name

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

Transport hazard class(es)

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

Packing group, if applicable

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

Environmental hazards

ADR/RID: No

IMDG: No

IATA: No

Special precautions for user

no data available

Transport in bulk according to IMO instruments

no data available

SECTION 15: Regulatory information

Safety, health and environmental regulations specific for the product in question

European Inventory of Existing Commercial Chemical Substances (EINECS)
Listed.
EC Inventory
Listed.
United States Toxic Substances Control Act (TSCA) Inventory
Listed.
China Catalog of Hazardous chemicals 2015
Not Listed.
New Zealand Inventory of Chemicals (NZIoC)
Listed.
PICCS
Listed.
Vietnam National Chemical Inventory
Listed.
IECSC
Listed.
Korea Existing Chemicals List (KECL)
Listed.

SECTION 16: Other information

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

Recommended Products
VANADIUM(III) CHLORIDE SDS Carbachol SDS CHOLINE-15N CHLORIDE SDS Chromic chloride hexahydrate SDS Lanthanum(III) chloride SDS Sodium chloride SDS Choline chloride SDS Trimethylamine SDS Succinylcholine Chloride SDS Lithium chloride SDS