Chemical Safety Data Sheet MSDS / SDS
Acetic anhydride
Revision Date:2026-04-11Revision Number:1
Product identifier
- Product name: Acetic anhydride
- CBnumber: CB2852742
- CAS: 108-24-7
- EINECS Number: 203-564-8
- Synonyms: acetic anhydride,Ac2O
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Hazard statements
H226 Flammable liquid and vapour
H302 Harmful if swallowed
H314 Causes severe skin burns and eye damage
H330 Fatal if inhaled
Substance
- Product name: Acetic anhydride
- Synonyms: acetic anhydride,Ac2O
- CAS: 108-24-7
- EC number: 203-564-8
- MF: C4 H6 O3
- MW: 102.09
4.1 Description of first-aid measures
General adviceFirst aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.
In case of eye contact
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist.
Remove contact lenses.
If swallowed
Remove contact lenses.
After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Call a physician immediately. Do not attempt to neutralise.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
4.4 Notes to physician
No data available
5.1 Extinguishing media
Suitable extinguishing mediaDry powder Carbon dioxide (CO2)
Unsuitable extinguishing media
Water Foam
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air at elevated temperatures.
Development of hazardous combustion gases or vapours possible in the event of fire.
Combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air at elevated temperatures.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
3
2
1
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 2 | Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur) | |
| REACT | 1 | Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene) | |
| SPEC. HAZ. |
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains. Risk of explosion.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.
Chemizorb®). Dispose of properly. Clean up affected area.
Chemizorb®). Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
Advice on safe handlingWork under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsKeep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition. Keep locked up or in an area accessible only to qualified or authorized persons.
Reacts violently with water.
Storage class
Reacts violently with water.
Storage class (TRGS 510): 3: Flammable liquids
8.1 Control parameters
Ingredients with workplace control parameters| ['Component', 'CAS-No.', 'Value', 'Control\nparameters', 'Basis'] | ['Acetic anhydride', '108-24-7', 'PC-TWA', '16 mg/m3', 'Occupational exposure limits for\nhazardous agents in the\nworkplace - Chemical\nhazardous agents.'] |
|---|
8.2 Exposure controls
Appropriate engineering controlsImmediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles
Skin protection
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: butyl-rubber
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Butoject® (KCL 898)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Latex gloves
Minimum layer thickness: 0.6 mm
Break through time: 60 min
Material tested:Lapren® (KCL 706 / Aldrich Z677558, Size M)
Internet: www.kcl.de).
Full contact
Material: butyl-rubber
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Butoject® (KCL 898)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Latex gloves
Minimum layer thickness: 0.6 mm
Break through time: 60 min
Material tested:Lapren® (KCL 706 / Aldrich Z677558, Size M)
Body Protection
Flame retardant antistatic protective clothing.
Respiratory protection
required when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Control of environmental exposure
Do not let product enter drains. Risk of explosion.
Information on basic physicochemical properties
- a) Physical stateliquid
- b) Colorcolorless
- c) Odorpungent
- d) Melting point/freezing pointMelting point/range: -73 °C - lit.
- e) Initial boiling point and boiling range138 - 140 °C - lit.
- f) Flammability (solid, gas)No data available
- g) Upper/lower flammability or explosive limitsUpper explosion limit: 10.3 %(V)
Lower explosion limit: 2.7 %(V) - h) Flash point49 °C - closed cup
- i) Autoignition temperature316 °C at 1,013.25 hPa
- j) Decomposition temperatureNo data available
- k) pH3 (10g/l, H2O, 20°C)
- l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: 0.84 mPa.s at 25 °C - m) Water solubility107 g/l at 15 °C - slightly solubleHydrolysis
- n) Partition coefficient n-octanol/waterlog Pow: ca.-0.5 at 20 °C - Bioaccumulation is not expected.
- o) Vapor pressure13 hPa at 36 °C
- p) Density1.08 g/cm3 - lit.
- Relative density1.087
- q) Relative vapor density3.5 (vs air)
- r) Particle characteristicsNo data available
- s) Explosive propertiesNo data available
- t) Oxidizing propertiesnone
- SolubilityMiscible with ether, chloroform and benzene.
- Dielectric constant20.0
9.2 Other safety information
Surface tension31.93 mN/m at 25 °C
10.1 Chemical stability
Decomposes when moist.
The product is chemically stable under standard ambient conditions (room temperature) .
The product is chemically stable under standard ambient conditions (room temperature) .
10.2 Possibility of hazardous reactions
Risk of explosion with: ethanol potassium permanganate
Strong oxidizing agents perchloric acid
Nitric acid hydrogen peroxide chromium(VI) oxide barium peroxide peroxi compounds ammonium nitrate with
Nitric acid
Exothermic reaction with:
Ammonia
Potassium hydroxide nitrates
Sodium hydroxide
Acetic acid, diluted
Violent reactions possible with:
Water
Possible formation of: acetic acid
Strong oxidizing agents perchloric acid
Nitric acid hydrogen peroxide chromium(VI) oxide barium peroxide peroxi compounds ammonium nitrate with
Nitric acid
Exothermic reaction with:
Ammonia
Potassium hydroxide nitrates
Sodium hydroxide
Acetic acid, diluted
Violent reactions possible with:
Water
Possible formation of: acetic acid
10.3 Conditions to avoid
Do not allow water to enter container because of violent reaction.
Heating.
Heating.
10.4 Incompatible materials
No data available
10.5 Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityLD50 Oral - Rat - male and female - 630 mg/kg
Remarks: (ECHA)
LC50 Inhalation - Rat - 4 h - > 0.5 - < 2 mg/l - vapor (OECD Test Guideline 412)
Remarks: (ECHA)
Dermal: No data available
Skin corrosion/irritation
Remarks: (ECHA)
LC50 Inhalation - Rat - 4 h - > 0.5 - < 2 mg/l - vapor (OECD Test Guideline 412)
Remarks: (ECHA)
Dermal: No data available
Skin - in vitro test
Result: Causes burns. - 4 h
Remarks: (ECHA)
Serious eye damage/eye irritation
Result: Causes burns. - 4 h
Remarks: (ECHA)
Eyes - Rat
Result: Corrosive - 24 h
Remarks: (ECHA)
Remarks: Causes serious eye damage.
Respiratory or skin sensitization
Result: Corrosive - 24 h
Remarks: (ECHA)
Remarks: Causes serious eye damage.
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Test Type: In vitro mammalian cell gene mutation test
Test system: mouse lymphoma cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Test Type: Chromosome aberration test in vitro
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Test Type: Micronucleus test
Species: Rat
Cell type: Bone marrow
Application Route: inhalation (vapor)
Method: OECD Test Guideline 474
Result: negative
Carcinogenicity
Test system: mouse lymphoma cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Test Type: Chromosome aberration test in vitro
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Test Type: Micronucleus test
Species: Rat
Cell type: Bone marrow
Application Route: inhalation (vapor)
Method: OECD Test Guideline 474
Result: negative
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
RTECS: AK1925000 burning sensation, Cough, wheezing, laryngitis, Shortness of breath, spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Toxicity to fish semi-static test LC50 - Oncorhynchus mykiss (rainbow trout) - > 300.82 mg/l - 96 h (OECD Test Guideline 203)
Remarks: (in analogy to similar products)
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - > 1,000 mg/l - 48 h and other aquatic (OECD Test Guideline 202) invertebrates
Toxicity to algae static test ErC50 - Skeletonema costatum - > 300.82 mg/l - 72 h (ISO 10253)
Toxicity to bacteria static test NOEC - Pseudomonas putida - 1,150 mg/l - 16 h
Remarks: (ECHA)
Remarks: (in analogy to similar products)
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - > 1,000 mg/l - 48 h and other aquatic (OECD Test Guideline 202) invertebrates
Toxicity to algae static test ErC50 - Skeletonema costatum - > 300.82 mg/l - 72 h (ISO 10253)
Toxicity to bacteria static test NOEC - Pseudomonas putida - 1,150 mg/l - 16 h
Remarks: (ECHA)
12.2 Persistence and degradability
Biodegradability Zahn-Wellens Test - Exposure time 5 d
Result: > 95 % - Readily biodegradable.
(OECD Test Guideline 302B)
Result: > 95 % - Readily biodegradable.
(OECD Test Guideline 302B)
12.3 Bioaccumulative potential
No bioaccumulation is to be expected (log Pow <= 4).
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
No data available
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Offer surplus and non-recyclable solutions to a licensed disposal company.
14.1 UN number
ADR/RID: 1715
IMDG: 1715
IATA-DGR: 1715
IMDG: 1715
IATA-DGR: 1715
14.2 UN proper shipping name
ADR/RID: ACETIC ANHYDRIDE
IMDG: ACETIC ANHYDRIDE
IATA-DGR: Acetic anhydride
IMDG: ACETIC ANHYDRIDE
IATA-DGR: Acetic anhydride
14.3 Transport hazard class(es)
ADR/RID: 8 (3)
IMDG: 8 (3)
IATA-DGR: 8 (3)
IMDG: 8 (3)
IATA-DGR: 8 (3)
14.4 Packaging group
ADR/RID: II
IMDG: II
IATA-DGR: II
IMDG: II
IATA-DGR: II
14.5 Environmental hazards
ADR/RID: no
IMDG Marine pollutant: no
IATA-DGR: no
IMDG Marine pollutant: no
IATA-DGR: no
14.6 Special precautions for user
Based on chemical properties, choose appropriate tools and conditions of transport.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
14.7 Incompatible materials
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulatory information
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.