Chemical Safety Data Sheet MSDS / SDS

Acetylacetone

Revision Date:2023-12-16Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: Acetylacetone
  • CBnumber: CB2179401
  • CAS: 123-54-6
  • EINECS Number: 204-634-0
  • Synonyms: acetylacetone,acac

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

  • Symbol(GHS)
  • Signal wordDanger
Precautionary statements
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P307+P311 IF exposed: call a POISON CENTER or doctor/physician.
P311 Call a POISON CENTER or doctor/physician.
P370+P378 In case of fire: Use … for extinction.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…
Hazard statements
H226 Flammable liquid and vapour
H302 Harmful if swallowed
H311 Toxic in contact with skin
H331 Toxic if inhaled
H335 May cause respiratory irritation
H336 May cause drowsiness or dizziness
H370 Causes damage to organs
H373 May cause damage to organs through prolonged or repeated exposure
H402 Harmful to aquatic life

SECTION 3: Composition/information on ingredients

Substance

  • Product name: Acetylacetone
  • Synonyms: acetylacetone,acac
  • CAS: 123-54-6
  • EC number: 204-634-0
  • MF: C5H8O2
  • MW: 100.12

SECTION 4: First aid measures

Description of first aid measures

General advice
First aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.
In case of eye contact
After eye contact: rinse out with plenty of water. Remove contact lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media
Carbon dioxide (CO2) Foam Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture

Carbon oxides Combustible.

Vapors are heavier than air and may spread along floors. Risk of dust explosion.

Forms explosive mixtures with air at elevated temperatures.

Development of hazardous combustion gases or vapours possible in the event of fire.

Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Further information

Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.

NFPA 704

2
3
0
HEALTH 2 Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine)
FIRE 3 Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone)
REACT 0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.

Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.

Environmental precautions

Do not let product enter drains. Risk of explosion.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.

Chemizorb?). Dispose of properly. Clean up affected area.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling

Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.

Advice on protection against fire and explosion

Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.

Hygiene measures

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition. Keep locked up or in an area accessible only to qualified or authorized persons.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits
Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment
Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Skin protection

required

Body Protection

Flame retardant antistatic protective clothing.

Respiratory protection

Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic compounds

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.

These measures have to be properly documented.

Control of environmental exposure

Do not let product enter drains. Risk of explosion.

Exposure limits
No exposure limit has been set.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • Appearancecolorless liquid
  • Odourester-like
  • Odour ThresholdNo data available
  • pH6 (200g/l, H2O, 20℃)
  • Melting point/freezing pointMelting point/range: -23 °C - lit.
  • Initial boiling point and boiling range140,4 °C - lit.
  • Flash point35 °C - closed cup - Regulation (EC) No. 440/2008, Annex, A.9
  • Evaporation rateNo data available
  • Flammability (solid, gas)No data available
  • Upper/lower flammability or explosive limits Upper explosion limit: 11,4 %(V) Lower explosion limit: 1,7 %(V)
  • Vapour pressure 7,9 hPa at 20 °C - OECD Test Guideline 104
  • Vapour density 3.5 (vs air)
  • Relative density0,97 at 20 °C - Regulation (EC) No. 440/2008, Annex, A.3
  • Water solubilityca.153,8 g/l at 20 °C - Regulation (EC) No. 440/2008, Annex, A.6- completely soluble
  • Partition coefficient: n-octanol/waterlog Pow: ca.0,68 at 40 °C - OECD Test Guideline 117 - Bioaccumulation is not expected.
  • Autoignition temperatureNo data available
  • Decomposition temperature Distillable in an undecomposed state at normal pressure.
  • ViscosityViscosity, kinematic: No data available Viscosity, dynamic: ca.0,76 mPa.s at 20 °Cca.0,63 mPa.s at 40 °C
  • Explosive propertiesNo data available
  • Oxidizing propertiesNo data available

Other safety information

Surface tension 72 mN/m at 1g/l at 20 °C

- Regulation (EC) No. 440/2008, Annex, A.5

SECTION 10: Stability and reactivity

Reactivity

Vapor/air-mixtures are explosive at intense warming.

Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

Possibility of hazardous reactions

Violent reactions possible with:

Acids Bases Amines Aldehydes anhydrides

Oxidizing agents Hydrogen fluoride Halogenated compounds Cyanides

Isocyanates alkalines bases

Risk of ignition or formation of inflammable gases or vapours with: hydrides

nitrides Alkali metals


Conditions to avoid

Heating.

Incompatible materials

Mild steel, Zinc, Copper, Nickel, various alloys

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity
LD50 Oral - Rat - female - 570 mg/kg
Remarks: (ECHA)
LC50 Inhalation - Rat - male and female - 4 h - 5,0305 mg/l (OECD Test Guideline 403)
Symptoms: mucosal irritations, Cough LD50 Dermal - Rabbit - female - 790 mg/kg Remarks: (ECHA)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 4 h Remarks: (ECHA)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: slight irritation Remarks: (ECHA)
Respiratory or skin sensitization
(OECD Test Guideline 429)
Germ cell mutagenicity
Laboratory experiments have shown mutagenic effects.
Test Type: Mutagenicity (mammal cell test): chromosome aberration. Test system: Chinese hamster ovary cells
Metabolic activation: without metabolic activation Method: OECD Test Guideline 473
Result: positive
Test Type: sister chromatid exchange assay Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 479
Result: positive
Test Type: In vitro mammalian cell gene mutation test Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 476
Result: negative
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471
Result: negative
Test Type: Micronucleus test Species: Mouse
Cell type: Bone marrow
Application Route: inhalation (vapor) Method: US-EPA
Result: negative
Test Type: comet assay Species: Rat
Cell type: Liver cells Application Route: Oral
Result: negative Remarks: (ECHA)
Carcinogenicity
No data available
Reproductive toxicity
Ingestion of excessive amounts by pregnant animals resulted in maternal and fetal toxicity. No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
Toxicity
LC50 (4 hrs) in rats: 1000 ppm (Carpenter)

SECTION 12: Ecological information

Toxicity

Toxicity to fish
flow-through test LC50 - Pimephales promelas (fathead minnow) - 104 mg/l - 96 h

(OECD Test Guideline 203)

Toxicity to daphnia and other aquatic invertebrates

static test EC50 - Daphnia magna (Water flea) - 25,9 mg/l - 48 h (OECD Test Guideline 202)

Toxicity to algae
static test ErC50 - Pseudokirchneriella subcapitata (green algae) - 83,22 mg/l - 72 h

(OECD Test Guideline 201)

Toxicity to bacteria
static test EC50 - activated sludge - 107,6 mg/l - 3 h

(OECD Test Guideline 209)

Persistence and degradability

Biodegradability aerobic - Exposure time 28 d

Result: 83 - 100 % - Readily biodegradable. (OECD Test Guideline 301C)

Ratio BOD/ThBOD 5,6 %

Remarks: (Lit.)

Bioaccumulative potential

No data available

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

Discharge into the environment must be avoided.

SECTION 13: Disposal considerations

Waste treatment methods

Incompatibilities

Vapors may form explosive mixture with air. Incompatible with oxidizers; contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. reducing agents; halogens, aliphatic amines; alkanolamines, organic acids; isocyanates.

Product

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

SECTION 14: Transport information

UN number

ADR/RID: 2310 IMDG: 2310 IATA: 2310

UN proper shipping name


ADR/RID: PENTANE-2,4-DIONE IMDG: PENTANE-2,4-DIONE


IATA: Pentane-2,4-dione

14.3

Transport hazard class(es)

ADR/RID: 3 (6.1) IMDG: 3 (6.1)


IATA: 3 (6.1)

14.4

Packaging group

ADR/RID: III IMDG: III


IATA: III

14.5

Environmental hazards

ADR/RID: no IMDG Marine pollutant: no


IATA: no

14.6

Special precautions for user

No data available


SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals
China Catalog of Hazardous chemicals 2015:Listed. website: https://www.mem.gov.cn/
Measures for Environmental Management of New Chemical Substances
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/
Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/
Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr
European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/
EC Inventory:Listed.
United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/
Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/
New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/

SECTION 16: Other information

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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