11.1 Information on toxicological effects
Acute toxicity
Acute toxicity estimate Oral - 470 mg/kg (Calculation method)
LD50 Oral - Rat - male - 470 mg/kg (OECD Test Guideline 401)
Acute toxicity estimate Inhalation - 4 h - 1,47 mg/l - vapor(Calculation method)
LC50 Inhalation - Rat - male and female - 4 h - 1,47 mg/l - vapor (OECD Test Guideline 403)
Acute toxicity estimate Dermal - 467 mg/kg (Calculation method)
LD50 Dermal - Rabbit - male - 467 mg/kg (OECD Test Guideline 402)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 24 h (OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation - 24 h
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: negative (OECD Test Guideline 406)
Germ cell mutagenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Human lymphocytes
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Mouse lymphoma test
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Test Type: Micronucleus test
Species: Mouse
Cell type: Bone marrow
Application Route: Oral
Method: OECD Test Guideline 475
Result: negative
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Oral - May cause damage to organs through prolonged or repeated exposure.
- Liver
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
Repeated dose toxicity - Rat - male and female - Oral - NOAEL (No observed adverse effect level) - 15 mg/kg - LOAEL (Lowest observed adverse effect level) - 60 mg/kg
RTECS: UD3483000
Cough, Shortness of breath, Headache, Nausea, Vomiting, Dizziness
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
After absorption:
We have no description of any toxic symptoms.
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.