Chemical Safety Data Sheet MSDS / SDS
Ammonium thioglycolate
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: Ammonium thioglycolate
- CBnumber: CB5445341
- CAS: 5421-46-5
- EINECS Number: 226-540-9
- Synonyms: mercapto-aceticacimonoammoniumsalt ;thiofacoa-50
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
Hazard statements
H317 May cause an allergic skin reaction
H301 Toxic if swalloed
H290 May be corrosive to metals
Substance
- Product name: Ammonium thioglycolate
- Synonyms: mercapto-aceticacimonoammoniumsalt ;thiofacoa-50
- CAS: 5421-46-5
- EC number: 226-540-9
- MF: C2H4O2S.H3N
- MW: 109.15
General advice
Show this safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.
In case of eye contact
After eye contact: rinse out with plenty of water. Remove contact lenses.
If swallowed
If swallowed: give water to drink (two glasses at most). Seek medical advice immediately. In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
Protection of first-aiders
For personal protection see section 8.
Notes to physician
No data available
Suitable extinguishing media
Water Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
Specific hazards during fire fighting
Mixture with combustible ingredients. Development of hazardous combustion gases or vapours possible in the event of fire.
Hazardous combustion products
Carbon oxides Nitrogen oxides (NOx) Sulphur oxides
Specific extinguishing methods
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Special protective equipment for fire-fighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
NFPA 704
2
0
0
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 0 | Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapours, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material . Dispose of properly. Clean up affected area.
Handling
Avoidance of contactStrong oxidizing agents Metals
Storage
Conditions for safe storageNo metal containers.
Further information on storage conditions
Tightly closed. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorised persons.
Storage class
6.1C, Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Recommended storage temperature
Recommended storage temperature see product label.
control parameter
Hazard composition and occupational exposure limitsDoes not contain substances with occupational exposure limits.
Engineering measures
No data available
Personal protective equipment
Respiratory protectionrequired when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Filter type ABEK
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Eye/face protection
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Safety glasses
Skin and body protection
Safety glasses
protective clothing
Hand protection
Material
Nitrile rubber
Break through time
480 min
Glove thickness
0.11 mm
Protective index
Full contact
Manufacturer
(KCL 740 / Aldrich Z677272, Size M)
Material
Nitrile rubber
Break through time
480 min
Glove thickness
0.11 mm
Protective index
Splash contact
Manufacturer
(KCL 740 / Aldrich Z677272, Size M)
Manufacturer
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
Remarks
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Hygiene measures
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Information on basic physicochemical properties
- Density1.190 g/cm3
- Water solubilitysoluble (20 °C)
- Partition coefficient: n-octanol/waterNo data available
- Autoignition temperatureNo data available
- Decomposition temperatureNo data available
- Viscosity, dynamicNo data available
- Viscosity, kinematicNo data available
- Flow timeNo data available
- Particle characteristics Particle sizeNo data available
- Molecular weight109.15 g/mol
- Oxidizing propertiesnone
- Explosive propertiesNot classified as explosive.
- Relative density1.22
- Relative vapor densityNo data available
- Vapor pressure0.001Pa at 25℃
- Lower explosion limit / Lower flammability limitNo data available
- Upper explosion limit / Upper flammability limitNo data available
- Burning rateNo data available
- Flammability (liquids)No data available
- Flammability (solid, gas)No data available
- Evaporation rateNo data available
- Flash pointNo data available
- Boiling point/boiling range115℃[at 101 325 Pa]
- Melting point/ rangeNo data available
- pHca. 6 (20 °C)
- Odor ThresholdNo data available
- Odorstrong skunk-like odor
- Colorcolourless
- Appearanceclear, liquid
- Viscosity9.06mm2/s
- Physical stateSolution
Reactivity
No data available
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions
No data available
Conditions to avoid
no information available
Incompatible materials
Strong oxidizing agents Metals
Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Mixture Acute toxicityOral: No data available
Inhalation: No data available
Acute toxicity estimate Dermal - 4,546 mg/kg (Calculation method)
Skin corrosion/irritation
Inhalation: No data available
Acute toxicity estimate Dermal - 4,546 mg/kg (Calculation method)
Classified based on available data. For more details, see section 2
Serious eye damage/eye irritation
Classified based on available data. For more details, see section 2
Respiratory or skin sensitization
Mixture may cause an allergic skin reaction.
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Components Ammonium thioglycolate
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Acute toxicity
LD50 Oral - Rat - male and female - 35 - 142 mg/kg (OECD Test Guideline 423)
Remarks: (ECHA)
Inhalation: No data available
LD50 Dermal - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 402)
Remarks: (71% solution) (ECHA)
LD50 Intraperitoneal - Mouse - 100 mg/kg
Remarks: (ECHA)
Inhalation: No data available
LD50 Dermal - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 402)
Remarks: (71% solution) (ECHA)
LD50 Intraperitoneal - Mouse - 100 mg/kg
Skin corrosion/irritation
Skin - Rabbit
Result: slight irritation - 4 h (OECD Test Guideline 404)
Remarks: (71% solution) (ECHA)
Result: slight irritation - 4 h (OECD Test Guideline 404)
Remarks: (71% solution) (ECHA)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: slight irritation - 72 h (OECD Test Guideline 405)
Remarks: (71% solution) (ECHA)
Result: slight irritation - 72 h (OECD Test Guideline 405)
Remarks: (71% solution) (ECHA)
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
May cause sensitisation by skin contact.
(OECD Test Guideline 429)
Remarks: (ECHA)
May cause sensitisation by skin contact.
(OECD Test Guideline 429)
Remarks: (ECHA)
Germ cell mutagenicity
Test Type: in vitro assay
Test system: S. typhimurium
Result: negative
Test system: S. typhimurium
Result: negative
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
Ecotoxicity
Components:
Ammonium thioglycolate:
Toxicity to fishRemarks: No data available
Persistence and degradability
Components:
Ammonium thioglycolate:
BiodegradabilityRemarks: No data available
Bioaccumulative potential
Components:
Ammonium thioglycolate:
BioaccumulationRemarks: No data available
Partition coefficient: noctanol/water
log Pow: 2.85
Mobility in soil
Components:
Ammonium thioglycolate:
Stability in soilRemarks: No data available
Other adverse effects
Components:
Ammonium thioglycolate:
Additional ecological informationNo data available
Disposal methods
Waste from residuesOffer surplus and non-recyclable solutions to a licensed disposal company.
International Regulations
IATA-DGR
UN/ID No. : UN 2922
Proper shipping name : Corrosive liquid, toxic, n.o.s.
(Ammonium thioglycolate)
Class : 8
Subsidiary risk : 6.1
Packing group : III
Labels : Class 8 - Corrosive substances, Division 6.1 - Toxic substances
Packing instruction (cargo aircraft) : 856
Packing instruction (passenger aircraft) : 852
Proper shipping name : Corrosive liquid, toxic, n.o.s.
(Ammonium thioglycolate)
Class : 8
Subsidiary risk : 6.1
Packing group : III
Labels : Class 8 - Corrosive substances, Division 6.1 - Toxic substances
Packing instruction (cargo aircraft) : 856
Packing instruction (passenger aircraft) : 852
IMDG-Code
UN number : UN 2922
Proper shipping name : CORROSIVE LIQUID, TOXIC, N.O.S.
(Ammonium thioglycolate)
Class : 8
Subsidiary risk : 6.1
Packing group : III
Labels : 8 (6.1)
EmS Code : F-A, S-B
Marine pollutant : no
Proper shipping name : CORROSIVE LIQUID, TOXIC, N.O.S.
(Ammonium thioglycolate)
Class : 8
Subsidiary risk : 6.1
Packing group : III
Labels : 8 (6.1)
EmS Code : F-A, S-B
Marine pollutant : no
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable for product as supplied.
National Regulations
JT/T 617
UN number : UN 2922
Proper shipping name : CORROSIVE LIQUID, TOXIC, N.O.S.
(Ammonium thioglycolate)
Class : 8
Subsidiary risk : 6.1
Packing group : III
Labels : 8 (6.1)
Environmentally hazardous : no
Proper shipping name : CORROSIVE LIQUID, TOXIC, N.O.S.
(Ammonium thioglycolate)
Class : 8
Subsidiary risk : 6.1
Packing group : III
Labels : 8 (6.1)
Environmentally hazardous : no
Special precautions for user
The transport classification(s) provided herein are for informational purposes only, and solely based upon the properties of the unpackaged material as it is described within this Safety Data Sheet. Transportation classifications may vary by mode of transportation, package sizes, and variations in regional or country regulations.
Catalogue of Hazardous Chemicals : This product is not listed in the catalogue of hazardous chemicals, but it meets the definition of hazardous chemicals and its principles of determination.
National regulatory information
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Identification of Major Hazard Installations for Hazardous Chemicals (GB 18218)
Not listed
Hazardous Chemicals for Priority Management
Not listed under SAWS
Catalogue of Specially Controlled Hazardous
Not listed Chemicals
List of Explosive Precursors
Not listed
Regulations on Labour Protection in Workplaces where Toxic Substances are Used
Catalogue of Highly Toxic Chemicals
Not listed
Regulation of Environmental Management on the First Import of Chemicals and the Import and Export of Toxic Chemicals
China Severely Restricted Toxic Chemicals for Import and Export
Not listed
Regulation on the Administration of Precursor Chemicals
Catalogue and Classification of Precursor Chemicals
Not listed
Regulations on the Administration of Controlled Chemicals
List of Controlled Chemicals
Not listed
Regulations of Ozone Depleting Substances Management
List of Controlled Ozone Depleting Substances
Not listed
List of Controlled Ozone Depleting Substances Import and Export
Not listed
Environmental Protection Law
List of Priority Controlled Chemicals
Not listed
List of Key Controlled New Pollutants
Not listed
Full text of other abbreviations
ACGIHUSA. ACGIH Threshold Limit Values (TLV)
ACGIH / TWA AIIC - Australian Invent Transport by Land of Bra bw - Body weight; CMR Standard of the German List (Canada); ECx - Conc associated with x% respo Chemical Substances (Jap response; ERG - Emerge GLP - Good Laboratory P cer; IATA - International Construction and Equipm Half maximal inhibitory c tion; IECSC - Inventory o tional Maritime Dangerou Industrial Safety and H Standardization; KECI - K tration to 50 % of a test (Median Lethal Dose); MA lution from Ships; n.o.s. No Observed (Adverse) E fect Level; NOELR - No Norm; NTP - National Toxi icals; OECD - Organizatio fice of Chemical Safety a and Toxic substance; PIC stances; (Q)SAR - (Quant (EC) No 1907/2006 of th Registration, Evaluation, Accelerating Decompositi Chemical Substance Inve Thailand Existing Chemica States); UN - United Nat Transport of Dangerous WHMIS - Workplace Hazar
8-hour, time-weighted average ry of Industrial Chemicals
ANTT - National Agency for il
ASTM - American Society for the Testing of Materials
- Carcinogen, Mutagen or Reproductive Toxicant
DIN nstitute for Standardisation
DSL - Domestic Substances ntration associated with x% response
ELx - Loading rate se
EmS - Emergency Schedule
ENCS - Existing and New n)
ErCx - Concentration associated with x% growth rate cy Response Guide
GHS - Globally Harmonized System
actice
IARC - International Agency for Research on Canir Transport Association
IBC - International Code for the nt of Ships carrying Dangerous Chemicals in Bulk
IC50 ncentration
ICAO - International Civil Aviation Organiza- Existing Chemical Substances in China
IMDG - Interna- Goods
IMO - International Maritime Organization
ISHL alth Law (Japan)
ISO - International Organisation for rea Existing Chemicals Inventory
LC50 - Lethal Concenopulation
LD50 - Lethal Dose to 50% of a test population POL - International Convention for the Prevention of Pol- Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC fect Concentration
NO(A)EL - No Observed (Adverse) Efbservable Effect Loading Rate
NOM - Official Mexican ology Program
NZIoC - New Zealand Inventory of Chemfor Economic Co-operation and Development
OPPTS - Ofd Pollution Prevention
PBT - Persistent, Bioaccumulative S - Philippines Inventory of Chemicals and Chemical Subtative) Structure Activity Relationship
REACH - Regulation European Parliament and of the Council concerning the uthorisation and Restriction of Chemicals
SADT - Selfn Temperature
SDS - Safety Data Sheet
TCSI - Taiwan tory
TDG - Transportation of Dangerous Goods
TECI s Inventory
TSCA - Toxic Substances Control Act (United ons
UNRTDG - United Nations Recommendations on the oods
vPvB - Very Persistent and Very Bioaccumulative
ous Materials Information System
ANTT - National Agency for il
ASTM - American Society for the Testing of Materials
- Carcinogen, Mutagen or Reproductive Toxicant
DIN nstitute for Standardisation
DSL - Domestic Substances ntration associated with x% response
ELx - Loading rate se
EmS - Emergency Schedule
ENCS - Existing and New n)
ErCx - Concentration associated with x% growth rate cy Response Guide
GHS - Globally Harmonized System
actice
IARC - International Agency for Research on Canir Transport Association
IBC - International Code for the nt of Ships carrying Dangerous Chemicals in Bulk
IC50 ncentration
ICAO - International Civil Aviation Organiza- Existing Chemical Substances in China
IMDG - Interna- Goods
IMO - International Maritime Organization
ISHL alth Law (Japan)
ISO - International Organisation for rea Existing Chemicals Inventory
LC50 - Lethal Concenopulation
LD50 - Lethal Dose to 50% of a test population POL - International Convention for the Prevention of Pol- Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC fect Concentration
NO(A)EL - No Observed (Adverse) Efbservable Effect Loading Rate
NOM - Official Mexican ology Program
NZIoC - New Zealand Inventory of Chemfor Economic Co-operation and Development
OPPTS - Ofd Pollution Prevention
PBT - Persistent, Bioaccumulative S - Philippines Inventory of Chemicals and Chemical Subtative) Structure Activity Relationship
REACH - Regulation European Parliament and of the Council concerning the uthorisation and Restriction of Chemicals
SADT - Selfn Temperature
SDS - Safety Data Sheet
TCSI - Taiwan tory
TDG - Transportation of Dangerous Goods
TECI s Inventory
TSCA - Toxic Substances Control Act (United ons
UNRTDG - United Nations Recommendations on the oods
vPvB - Very Persistent and Very Bioaccumulative
ous Materials Information System
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.