Chemical Safety Data Sheet MSDS / SDS

Benzyl chloroformate

Revision Date:2023-12-07Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: Benzyl chloroformate
  • CBnumber: CB7853678
  • CAS: 501-53-1
  • EINECS Number: 207-925-0
  • Synonyms: Cbz,benzyl chloroformate

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

  • Symbol(GHS)
  • Signal wordDanger
Precautionary statements
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P307+P311 IF exposed: call a POISON CENTER or doctor/physician.
P309 IF exposed or if you feel unwell:
P310 Immediately call a POISON CENTER or doctor/physician.
P370+P378 In case of fire: Use … for extinction.
P390 Absorb spillage to prevent material damage.
P391 Collect spillage. Hazardous to the aquatic environment
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P406 Store in corrosive resistant/… container with a resistant inner liner.
P501 Dispose of contents/container to..…
P264 Wash skin thouroughly after handling.
P264 Wash hands thoroughly after handling.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P240 Ground/bond container and receiving equipment.
P234 Keep only in original container.
P233 Keep container tightly closed.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P202 Do not handle until all safety precautions have been read and understood.
P201 Obtain special instructions before use.
Hazard statements
H225 Highly Flammable liquid and vapour
H227 Combustible liquid
H290 May be corrosive to metals
H303 May be harmfulif swallowed
H304 May be fatal if swallowed and enters airways
H314 Causes severe skin burns and eye damage
H318 Causes serious eye damage
H330 Fatal if inhaled
H332 Harmful if inhaled
H335 May cause respiratory irritation
H336 May cause drowsiness or dizziness
H350 May cause cancer
H360 May damage fertility or the unborn child
H370 Causes damage to organs
H372 Causes damage to organs through prolonged or repeated exposure
H400 Very toxic to aquatic life
H401 Toxic to aquatic life
H410 Very toxic to aquatic life with long lasting effects

SECTION 3: Composition/information on ingredients

Substance

  • Product name: Benzyl chloroformate
  • Synonyms: Cbz,benzyl chloroformate
  • CAS: 501-53-1
  • EC number: 207-925-0
  • MF: C8H7ClO2
  • MW: 170.59

SECTION 4: First aid measures

Description of first aid measures

General advice
First aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.
In case of eye contact
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.
If swallowed
After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Call a physician immediately. Do not attempt to neutralise.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media
Water Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture

Carbon oxides Hydrogen chloride gas Phosgene

Carbon oxides Hydrogen chloride gas Combustible.

Vapors are heavier than air and may spread along floors. Risk of dust explosion.

Forms explosive mixtures with air on intense heating.

Development of hazardous combustion gases or vapours possible in the event of fire.

Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Further information

Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

NFPA 704

3
2
1
HEALTH 3 Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
FIRE 2 Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur)
REACT 1 Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.

Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.

Environmental precautions

Do not let product enter drains.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.

Chemizorb?). Dispose of properly. Clean up affected area.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling

Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.

Advice on protection against fire and explosion

Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.

Hygiene measures

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Tightly closed. Keep in a well-ventilated place. Keep locked up or in an area accessible only

to qualified or authorized persons.

Storage stability

Recommended storage temperature

-20 °C

Moisture sensitive. Heat sensitive. Over time, pressure may increase causing containers to burst

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits
Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment
Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.

Full contact

Material: Fluorinated rubber Minimum layer thickness: 0,7 mm

Break through time: 480 min

Material tested:Vitoject? (KCL 890 / Aldrich Z677698, Size M)

Splash contact

Material: Fluorinated rubber Minimum layer thickness: 0,7 mm Break through time: 480 min

Material tested:Vitoject? (KCL 890 / Aldrich Z677698, Size M)

data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374

If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

protective clothing

Respiratory protection

required when vapours/aerosols are generated.

Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

Recommended Filter type: Filter type ABEK

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.

These measures have to be properly documented.

Control of environmental exposure

Do not let product enter drains.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • Appearancelight yellow liquid, clear
  • Odourpungent
  • Odour ThresholdNo data available
  • pHNo data available
  • Melting point/freezing pointMelting point/range: -18 °C
  • Initial boiling point and boiling range152 °C
  • Flash point92 °C - closed cup
  • Evaporation rateNo data available
  • Flammability (solid, gas)No data available
  • Upper/lower flammability or explosive limitsNo data available
  • Vapour pressure 95,809 hPa at 20 °C 195,065 hPa at 55 °C
  • Vapour density 5,89 - (Air = 1.0)
  • Relative density1,217 g/cm3 at 20 °C No data available
  • Water solubilityMiscible with ether, acetone and benzene.
  • Partition coefficient: n-octanol/waterNo data available
  • Autoignition temperatureNo data available
  • Decomposition temperatureNo data available
  • ViscosityViscosity, kinematic: No data available Viscosity, dynamic: No data available
  • Explosive propertiesNo data available
  • Oxidizing propertiesNo data available

Other safety information

Relative vapor density

5,89 - (Air = 1.0)

SECTION 10: Stability and reactivity

Reactivity

Can violently decompose at elevated temperatures Forms explosive mixtures with air on intense heating.

A range from approx. 15 Kelvin below the flash point is to be rated as critical. Contact with water liberates toxic gas.

Chemical stability

To avoid thermal decomposition, do not overheat. Decomposes when moist.

The product is chemically stable under standard ambient conditions (room temperature) .

Possibility of hazardous reactions

May decompose on exposure to moist air or water.


Conditions to avoid

Heat, flames and sparks. Exposure to moisture. Do not heat over: 75° C Strong heating.

Incompatible materials

No data available

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity
Acute toxicity estimate Oral - > 2.000 mg/kg (Calculation method)
Inhalation
Skin corrosion/irritation
No data available
Serious eye damage/eye irritation
No data available
Respiratory or skin sensitization
No data available
Germ cell mutagenicity
No data available
Carcinogenicity
No data available
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
Toxicity
LD50 orally in Rabbit: 3000 mg/kg

SECTION 12: Ecological information

Toxicity

No data available

Persistence and degradability

No data available

Bioaccumulative potential

No data available

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

No data available

SECTION 13: Disposal considerations

Waste treatment methods

Product

See www.retrologistik.com for processes regarding the return of chemicals and

containers, or contact us there if you have further questions.

SECTION 14: Transport information

UN number

ADR/RID: 1739 IMDG: 1739 IATA: 1739

UN proper shipping name


ADR/RID: BENZYL CHLOROFORMATE IMDG: BENZYL CHLOROFORMATE


IATA: Benzyl chloroformate

Passenger Aircraft: Not permitted for transport

14.3

Transport hazard class(es)

ADR/RID: 8 IMDG: 8


IATA: 8

14.4

Packaging group

ADR/RID: I IMDG: I


IATA: I

14.5

Environmental hazards

ADR/RID: yes IMDG Marine pollutant: yes


IATA: no

14.6

Special precautions for user

No data available


SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals
China Catalog of Hazardous chemicals 2015:Listed. website: https://www.mem.gov.cn/
Measures for Environmental Management of New Chemical Substances
Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/
United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/
Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/
New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/
Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr
European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/
EC Inventory:Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/

SECTION 16: Other information

Abbreviations and acronyms

  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • CAS: Chemical Abstracts Service
  • EC50: Effective Concentration 50%
  • IATA: International Air Transportation Association
  • IMDG: International Maritime Dangerous Goods
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • STEL: Short term exposure limit
  • TWA: Time Weighted Average

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort.Rest and medical observation is therefore essential.Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered.
Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

Recommended Products
Benzyl chloride SDS Phenyl chloroformate SDS Calcium chloride SDS Benzyl alcohol SDS Folic acid SDS Ferric chloride SDS 9-Fluorenylmethyl chloroformate SDS (-)-MENTHYL CHLOROFORMATE SDS 4-Nitrobenzyl chloroformate SDS Citric acid SDS