Chemical Safety Data Sheet MSDS / SDS

BROMODICHLOROMETHANE

Revision Date:2024-03-16Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: BROMODICHLOROMETHANE
  • CBnumber: CB2186236
  • CAS: 75-27-4
  • EINECS Number: 200-856-7
  • Synonyms: Bromodichloromethane,BDCM

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

  • Symbol(GHS)
  • Signal wordDanger
Precautionary statements
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P311 Call a POISON CENTER or doctor/physician.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…
Hazard statements
H225 Highly Flammable liquid and vapour
H302 Harmful if swallowed
H315 Causes skin irritation
H318 Causes serious eye damage
H335 May cause respiratory irritation
H340 May cause genetic defects
H351 Suspected of causing cancer
H360 May damage fertility or the unborn child
H370 Causes damage to organs
H373 May cause damage to organs through prolonged or repeated exposure
H402 Harmful to aquatic life
Disposal
WARNING.Cancer - https://oehha.ca.gov/proposition-65/chemicals/bromodichloromethane

SECTION 3: Composition/information on ingredients

Substance

  • Product name: BROMODICHLOROMETHANE
  • Synonyms: Bromodichloromethane,BDCM
  • CAS: 75-27-4
  • EC number: 200-856-7
  • MF: CHBrCl2
  • MW: 163.83

SECTION 4: First aid measures

Description of first aid measures

General advice
Consult a physician. Show this material safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from the substance or mixture

Carbon oxides, Hydrogen chloride gas, Hydrogen bromide gas

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

Further information

No data available

NFPA 704

2
0
0
HEALTH 2 Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine)
FIRE 0 Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride)
REACT 0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.

For personal protection see section 8.

Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Methods and materials for containment and cleaning up

Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits
Does not contain substances with occupational exposure limits.

Exposure controls

Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment
Eye/face protection

Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.

Splash contact

Material: Fluorinated rubber Minimum layer thickness: 0,7 mm Break through time: 120 min

Material tested:Vitoject? (KCL 890 / Aldrich Z677698, Size M)

data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374

If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

Where risk assessment shows air-purifying respirators are appropriate use a full- face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • Appearancecolorless liquid, clear
  • OdourNo data available
  • Odour ThresholdNo data available
  • pHNo data available
  • Melting point/freezing pointMelting point/range: -55 °C - lit.
  • Initial boiling point and boiling range87 °C - lit.
  • Flash point87-89°C
  • Evaporation rateNo data available
  • Flammability (solid, gas)No data available
  • Upper/lower flammability or explosive limitsNo data available
  • Vapour pressure 50 at 20 °C (Dreisbach, 1952)
  • Vapour density No data available
  • Relative density1,98 g/cm3 at 25 °C
  • Water solubilityinsoluble
  • Partition coefficient: n-octanol/waterNo data available
  • Autoignition temperatureNo data available
  • Decomposition temperatureNo data available
  • ViscosityNo data available
  • Explosive propertiesNo data available
  • Oxidizing propertiesNo data available
  • Henry's Law ConstantIn seawater (salinity 30.4‰): 5.52, 10.51, and 18.97 at 0, 10, and 20 °C, respectively (Moore et al., 1995)

Other safety information

No data available

SECTION 10: Stability and reactivity

Reactivity

No data available

Chemical stability

Stable under recommended storage conditions.

Possibility of hazardous reactions

No data available

Conditions to avoid

No data available

Incompatible materials

Strong oxidizing agents, Strong bases, Magnesium

Hazardous decomposition products

Hazardous decomposition products formed under fire conditions. - Carbon oxides, Hydrogen chloride gas, Hydrogen bromide gas

Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity
LD50 Oral - Mouse - 450,0 mg/kg
Remarks: Brain and Coverings:Changes in circulation (hemorrhage,thrombosis, etc.). Liver:Fatty liver degeneration. Blood: Hemorrhage.
TDLo Oral - Rat - 40 mg/kg
Remarks: Nutritional and Gross Metabolic:Weight loss or decreased weight gain. TDLo Oral - Rat - 35 mg/kg
Remarks: Liver:Other changes. Kidney, Ureter, Bladder:Other changes. TDLo Oral - Rat - 20,5 mg/kg
Remarks: Liver:Liver function tests impaired. TDLo Oral - Rat - 400 mg/kg
Remarks: Biochemical:Enzyme inhibition, induction, or change in blood or tissue lev hydroxylation, etc.). Liver:Other changes.
TDLo Oral - Rat - 2.000 mg/kg
Remarks: Kidney, Ureter, Bladder:Changes in both tubules and glomeruli. Kidney, Ureter, Bladder:Other changes in urine composition.
TDLo Oral - Rat - 9.828 mg/kg
Remarks: Blood:Changes in erythrocyte (RBC) count. Nutritional and Gross Metabolic:Weight loss or decreased weight gain. Biochemical:Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases.
TDLo Oral - Rat - 2.904,6 mg/kg
Remarks: Behavioral:Fluid intake. Nutritional and Gross Metabolic:Weight loss or decreased weight gain. Nutritional and Gross Metabolic:Dehydration.
TDLo Oral - Rat - 5.366,9 mg/kg
Remarks: Kidney, Ureter, Bladder:Changes in kidney weight. Endocrine:Other changes. Skin and Appendages: Other: Hair.
TDLo Oral - Rat - 3.127 mg/kg
Remarks: Behavioral:Fluid intake. Nutritional and Gross Metabolic:Weight loss or decreased weight gain.
TDLo Oral - Rat - 20.075 mg/kg
Remarks: Liver:Fatty liver degeneration. Liver:Other changes. Liver:Changes in liver weight.
TDLo Oral - Rat - 5.670 mg/kg
Remarks: Liver:Changes in liver weight. Blood:Changes in serum composition (e.g., TP, bilirubin, cholesterol). Nutritional and Gross Metabolic:Weight loss or decreased weight gain.
TDLo Oral - Rat - 742 mg/kg
Remarks: Nutritional and Gross Metabolic:Weight loss or decreased weight gain. Behavioral:Food intake (animal).
TDLo Oral - Rat - 2.000 mg/kg
Remarks: Kidney, Ureter, Bladder:Changes in both tubules and glomeruli. Kidney, Ureter, Bladder:Other changes in urine composition.
TDLo Oral - Rat - 375 mg/kg
Remarks: Endocrine:Estrogenic. Blood:Changes in serum composition (e.g., TP, bilirubin, cholesterol).
TDLo Oral - Rat - 750 mg/kg
Remarks: Biochemical:Enzyme inhibition, induction, or change in blood or tissue lev hydroxylation, etc.). Liver:Changes in liver weight. Kidney, Ureter, Bladder:Other changes. TDLo Oral - Mouse - 1.000 mg/kg
Remarks: Kidney, Ureter, Bladder:Renal function tests depressed. Blood:Changes in serum composition (e.g., TP, bilirubin, cholesterol).
TDLo Oral - Mouse - 750 mg/kg
Remarks: Biochemical:Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases. Biochemical:Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases. Liver:Changes in liver weight.
TDLo Oral - Rabbit - 59,5 mg/kg
Remarks: Behavioral:Fluid intake. Behavioral:Food intake (animal).
Skin corrosion/irritation
Irritating to eyes, respiratory system and skin.
Serious eye damage/eye irritation
No data available
Respiratory or skin sensitization
No data available
Germ cell mutagenicity
Laboratory experiments have shown mutagenic effects.
Carcinogenicity
This product is or contains a component that has been reported to be possibly carcinogenic based on its IARC, ACGIH, NTP, or EPA classification.
Limited evidence of carcinogenicity in animal studies
IARC: 2B - Group 2B: Possibly carcinogenic to humans (Bromodichloromethane) IARC: 2B - Group 2B: Possibly carcinogenic to humans (Bromodichloromethane)
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
Inhalation - May cause respiratory irritation.
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
Additional Information
RTECS: PA5310000
prolonged or repeated exposure can cause:, Nausea, Dizziness, Headache, narcosis
Toxicity
LD50 in male, female mice (mg/kg): 450, 900 orally (Bowman)

SECTION 12: Ecological information

Toxicity

No data available

Persistence and degradability

No data available

Bioaccumulative potential

No data available

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

No data available

SECTION 13: Disposal considerations

Waste treatment methods

Product

Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging

Dispose of as unused product.

SECTION 14: Transport information

UN number

ADR/RID: - IMDG: - IATA: -

UN proper shipping name

ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods

Transport hazard class(es)

ADR/RID: - IMDG: - IATA: -

Packaging group

ADR/RID: - IMDG: - IATA: -

Environmental hazards

ADR/RID: no IMDG Marine pollutant: no IATA: no

Special precautions for user

No data available

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals
China Catalog of Hazardous chemicals 2015:Not Listed. website: https://www.mem.gov.cn/
Measures for Environmental Management of New Chemical Substances
EC Inventory:Listed.
European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/
New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/
United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/
Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Not Listed. website: https://www.mee.gov.cn/
Korea Existing Chemicals List (KECL):Not Listed. website: http://ncis.nier.go.kr
Philippines Inventory of Chemicals and Chemical Substances (PICCS):Not Listed. website: https://emb.gov.ph/

SECTION 16: Other information

Abbreviations and acronyms

  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • CAS: Chemical Abstracts Service
  • EC50: Effective Concentration 50%
  • IATA: International Air Transportation Association
  • IMDG: International Maritime Dangerous Goods
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • STEL: Short term exposure limit
  • TWA: Time Weighted Average

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

Bromodichloromethane can be found in chlorinated water.Health effects of exposure to the substance have not been investigated adequately other than by ingestion.
Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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