Chemical Safety Data Sheet MSDS / SDS
Chloroacetyl chloride
Revision Date:2026-04-11Revision Number:1
Product identifier
- Product name: Chloroacetyl chloride
- CBnumber: CB6202877
- CAS: 79-04-9
- EINECS Number: 201-171-6
- Synonyms: chloroacetyl chloride,2-chloroacetyl chloride
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P314 Get medical advice/attention if you feel unwell.
Hazard statements
H314 Causes severe skin burns and eye damage
H372 Causes damage to organs through prolonged or repeated exposure
H400 Very toxic to aquatic life
Substance
- Product name: Chloroacetyl chloride
- Synonyms: chloroacetyl chloride,2-chloroacetyl chloride
- CAS: 79-04-9
- EC number: 201-171-6
- MF: C2H2Cl2O
- MW: 112.94
4.1 Description of first-aid measures
General adviceFirst aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.
In case of eye contact
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist.
Remove contact lenses.
If swallowed
Remove contact lenses.
If swallowed: give water to drink (two glasses at most). Seek medical advice immediately.
In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible. Do not attempt to neutralise.
In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible. Do not attempt to neutralise.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
4.4 Notes to physician
No data available
5.1 Extinguishing media
Suitable extinguishing mediaUse extinguishing measures that are appropriate to local circumstances and the surrounding environment.
Unsuitable extinguishing media
Water Foam
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Hydrogen chloride gas
Not combustible.
corrosive vapours
Fire may cause evolution of:
Hydrogen chloride gas, Chlorine, Phosgene, dioxin
Vapors are heavier than air and may spread along floors.
May not get in touch with: Water
Forms explosive mixtures with air on intense heating.
Ambient fire may liberate hazardous vapours.
Hydrogen chloride gas
Not combustible.
corrosive vapours
Fire may cause evolution of:
Hydrogen chloride gas, Chlorine, Phosgene, dioxin
Vapors are heavier than air and may spread along floors.
May not get in touch with: Water
Forms explosive mixtures with air on intense heating.
Ambient fire may liberate hazardous vapours.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
3
0
1
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 0 | Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride) | |
| REACT | 1 | Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene) | |
| SPEC. HAZ. |
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.
Chemizorb®). Dispose of properly. Clean up affected area.
Chemizorb®). Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
Advice on safe handlingWork under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Keep workplace dry. Do not allow product to come into contact with water.
Hygiene measures
Keep workplace dry. Do not allow product to come into contact with water.
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsTightly closed. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons.
Never allow product to get in contact with water during storage.
Recommended storage temperature see product label.
Storage class
Never allow product to get in contact with water during storage.
Recommended storage temperature see product label.
Storage class (TRGS 510): 6.1A: Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
8.1 Control parameters
Ingredients with workplace control parameters| ['Component', 'CAS-No.', 'Value', 'Control\nparameters', 'Basis'] | ['chloroacetyl', '79-04-9', 'PC-TWA', '0.2 mg/m3', 'Occupational exposure limits for'] | |
|---|---|---|
| ['', 'Remarks', 'Skin', None, None] | ['', '', 'PC-STEL', '0.6 mg/m3', 'Occupational exposure limits for\nhazardous agents in the\nworkplace - Chemical\nhazardous agents.'] | ['', '', 'Skin', None, None] |
8.2 Exposure controls
Appropriate engineering controlsImmediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles
Skin protection
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:KCL 741 L
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:KCL 741 L
Internet: www.kcl.de).
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:KCL 741 L
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:KCL 741 L
Body Protection
protective clothing
Respiratory protection
required when vapours/aerosols are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Control of environmental exposure
Do not let product enter drains.
Information on basic physicochemical properties
- a) Physical stateliquid
- b) Coloryellow
- c) Odorstrong pungent odor
- d) Melting point/freezing pointMelting point: -21.77 °C
- e) Initial boiling point and boiling range106 °C at 10,132 hPa
- f) Flammability (solid, gas)No data available
- g) Upper/lower flammability or explosive limitsNo data available
- h) Flash point100 °C - closed cup
- i) Autoignition temperatureNo data available
- j) Decomposition temperatureNo data available
- k) pHNo data available
- l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: 988 mPa.s at 20 °C - m) Water solubilityinsoluble
- n) Partition coefficient n-octanol/waterNo data available
- o) Vapor pressure25.3 hPa at 20 °C
- p) Density1.42 g/cm3 at 20 °C
- Relative density1.419 g/mL at 20 °C
- q) Relative vapor density3.9 (vs air)
- r) Particle characteristicsNo data available
- s) Explosive propertiesNo data available
- t) Oxidizing propertiesnone
- SolubilityMiscible with ethyl ether, acetone, benzene and carbon tetrachloride.
9.2 Other safety information
Surface tension0.04 mN/m at -22 °C
10.1 Chemical stability
sensitive to moisture
10.2 Possibility of hazardous reactions
Risk of explosion with:
Amines
Alkali metals
Alkaline earth metals
Powdered metals
Violent reactions possible with:
Water
Alcohols
Exothermic reaction with:
Sulphuric acid sodium amide alkali hydroxides
Amines
Alkali metals
Alkaline earth metals
Powdered metals
Violent reactions possible with:
Water
Alcohols
Exothermic reaction with:
Sulphuric acid sodium amide alkali hydroxides
10.3 Conditions to avoid
Exposure to moisture.
Strong heating.
Moisture.
Strong heating.
Moisture.
10.4 Incompatible materials
Aluminum, Iron, Mild steel, Zinc
10.5 Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityLD50 Oral - Rat - female - 50 - 100 mg/kg (OECD Test Guideline 401)
LC50 Inhalation - Mouse - 4 h - 3.01 mg/l - vapor
Remarks: (RTECS)
LD50 Dermal - Rat - 662 mg/kg
Remarks: (RTECS)
Skin corrosion/irritation
LC50 Inhalation - Mouse - 4 h - 3.01 mg/l - vapor
Remarks: (RTECS)
LD50 Dermal - Rat - 662 mg/kg
Remarks: (RTECS)
Skin - Rabbit
Result: Causes severe burns.
Remarks: (ECHA)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Serious eye damage/eye irritation
Result: Causes severe burns.
Remarks: (ECHA)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Eyes - Rabbit
Result: Severe eye irritation (Draize Test)
Remarks: (RTECS)
Remarks: Causes serious eye damage.
Respiratory or skin sensitization
Result: Severe eye irritation (Draize Test)
Remarks: (RTECS)
Remarks: Causes serious eye damage.
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Causes damage to organs through prolonged or repeated exposure.
- Lungs
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Aspiration hazard
- Lungs
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Classified based on available data. For more details, see section 2
11.2 Additional Information
burning sensation, Cough, wheezing, laryngitis, Shortness of breath, spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Decomposition of the substance with tissue moisture.
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
Decomposition of the substance with tissue moisture.
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
12.1 Toxicity
Toxicity to fish LC50 - Poecilia reticulata (guppy) - 369 mg/l - 96 h
Remarks: (ECHA)
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - 77 mg/l - 48 h and other aquatic (DIN 38412) invertebrates
Toxicity to algae static test ErC50 - Desmodesmus subspicatus (green algae) - 0.033 mg/l - 72 h (OECD Test Guideline 201)
Toxicity to bacteria static test NOEC - Pseudomonas putida - > 1,000 mg/l - 3 h (OECD Test Guideline 209)
Toxicity to NOEC - Danio rerio (zebra fish) - 12.5 mg/l - 28 Days fish(Chronic toxicity) Remarks: (ECHA)
Toxicity to daphnia semi-static test NOEC - Daphnia magna (Water flea) - 32 mg/l - 21 and other aquatic d invertebrates(Chronic Remarks: (ECHA) toxicity)
Remarks: (ECHA)
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - 77 mg/l - 48 h and other aquatic (DIN 38412) invertebrates
Toxicity to algae static test ErC50 - Desmodesmus subspicatus (green algae) - 0.033 mg/l - 72 h (OECD Test Guideline 201)
Toxicity to bacteria static test NOEC - Pseudomonas putida - > 1,000 mg/l - 3 h (OECD Test Guideline 209)
Toxicity to NOEC - Danio rerio (zebra fish) - 12.5 mg/l - 28 Days fish(Chronic toxicity) Remarks: (ECHA)
Toxicity to daphnia semi-static test NOEC - Daphnia magna (Water flea) - 32 mg/l - 21 and other aquatic d invertebrates(Chronic Remarks: (ECHA) toxicity)
12.2 Persistence and degradability
Biodegradability
Result: 100 % - Readily biodegradable.
(OECD Test Guideline 301C)
Remarks: Hydrolysis (IUCLID)
Result: 100 % - Readily biodegradable.
(OECD Test Guideline 301C)
Remarks: Hydrolysis (IUCLID)
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
Biological effects:
Product reacts with water.
Hazardous decomposition products
Harmful effect due to pH shift.
Forms toxic and corrosive mixtures with water even if diluted.
Discharge into the environment must be avoided.
Product reacts with water.
Hazardous decomposition products
Harmful effect due to pH shift.
Forms toxic and corrosive mixtures with water even if diluted.
Discharge into the environment must be avoided.
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Offer surplus and non-recyclable solutions to a licensed disposal company.
14.1 UN number
ADR/RID: 1752
IMDG: 1752
IATA-DGR: 1752
IMDG: 1752
IATA-DGR: 1752
14.2 UN proper shipping name
ADR/RID: CHLOROACETYL CHLORIDE
IMDG: CHLOROACETYL CHLORIDE
IATA-DGR: Chloroacetyl chloride
Passenger Aircraft: Not permitted for transport
Cargo Aircraft: Not permitted for transport
IMDG: CHLOROACETYL CHLORIDE
IATA-DGR: Chloroacetyl chloride
Passenger Aircraft: Not permitted for transport
Cargo Aircraft: Not permitted for transport
14.3 Transport hazard class(es)
ADR/RID: 6.1 (8)
IMDG: 6.1 (8)
IATA-DGR: 6.1 (8)
IMDG: 6.1 (8)
IATA-DGR: 6.1 (8)
14.4 Packaging group
ADR/RID: I
IMDG: I
IATA-DGR: -
IMDG: I
IATA-DGR: -
14.5 Environmental hazards
ADR/RID: yes
IMDG Marine pollutant: yes
IATA-DGR: no
IMDG Marine pollutant: yes
IATA-DGR: no
14.6 Special precautions for user
Based on chemical properties, choose appropriate tools and conditions of transport.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
14.7 Incompatible materials
Aluminum, Iron, Mild steel, Zinc
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulatory information
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number : B1A222225566
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number : B1A222225566
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.