11.1 Information on toxicological effects
Acute toxicity
Oral: No data available
LD50 Oral - Rat - male - 908 mg/kg (OECD Test Guideline 401)
Acute toxicity estimate Oral - 908 mg/kg (ATE value derived from LD50/LC50 value)
Acute toxicity estimate Inhalation - 4 h - 3,1 mg/l - vapor(Calculation method)
LC50 Inhalation - Rat - 6 h - 9,17 mg/l - vapor
Acute toxicity estimate Inhalation - Expert judgment - 4 h - 3,1 mg/l - vapor
Dermal: No data available
Skin corrosion/irritation
Skin - Rabbit
Result: Irritating to skin. - 24 h
Remarks: (ECHA)
Remarks: Drying-out effect resulting in rough and chapped skin.
Skin - Rabbit
Result: slight irritation
Remarks: (IUCLID)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Irritating to eyes.
Remarks: (ECHA)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: negative (Regulation (EC) No. 440/2008, Annex, B.6)
Germ cell mutagenicity
Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Result: negative
Remarks: (ECHA)
Test Type: unscheduled DNA synthesis assay
Test system: Liver
Metabolic activation: without metabolic activation
Result: negative
Remarks: (ECHA)
Test Type: Micronucleus test
Species: Rat
Cell type: Red blood cells (erythrocytes)
Application Route: Oral
Method: OECD Test Guideline 474
Result: negative
Test Type: unscheduled DNA synthesis assay
Species: Rat
Cell type: Liver cells
Application Route: Oral
Method: OECD Test Guideline 486
Result: negative
Test Type: in vivo assay
Species: Mouse
Application Route: Inhalation
Result: negative
Remarks: (ECHA)
Carcinogenicity
Suspected of causing cancer.
Reproductive toxicity
Suspected of damaging the unborn child.
Specific target organ toxicity - single exposure
May cause drowsiness or dizziness.
Specific target organ toxicity - repeated exposure
Oral - Causes damage to organs through prolonged or repeated exposure.
- Liver, Kidney
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
Repeated dose toxicity - Rat - female - Oral - NOAEL (No observed adverse effect level) - 34 mg/kg
RTECS: FS9100000
Vomiting, Cough, irritant effects, Shortness of breath, respiratory arrest, narcosis,
Dizziness, Nausea, agitation, spasms, inebriation, Headache, Stomach/intestinal disorders, ataxia (impaired locomotor coordination), cardiovascular disorders
Drying-out effect resulting in rough and chapped skin.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.