Chemical Safety Data Sheet MSDS / SDS
Cyclopropyl methyl ketone
Revision Date:2026-04-11Revision Number:1
Product identifier
- Product name: Cyclopropyl methyl ketone
- CBnumber: CB2201645
- CAS: 765-43-5
- EINECS Number: 212-146-4
- Synonyms: Cyclopropyl Methyl Ketone,CPMK
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P242 Use only non-sparking tools.
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment.
P240 Ground/bond container and receiving equipment.
P233 Keep container tightly closed.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
Hazard statements
H225 Highly Flammable liquid and vapour
H301 Toxic if swalloed
Substance
- Product name: Cyclopropyl methyl ketone
- Synonyms: Cyclopropyl Methyl Ketone,CPMK
- CAS: 765-43-5
- EC number: 212-146-4
- MF: C5H8O
- MW: 84.12
4.1 Description of first-aid measures
General adviceFirst aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.
In case of eye contact
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist.
Remove contact lenses.
If swallowed
Remove contact lenses.
After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Call a physician immediately. Do not attempt to neutralise.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
4.4 Notes to physician
No data available
5.1 Extinguishing media
Suitable extinguishing mediaCarbon dioxide (CO2) Foam Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Combustible.
Pay attention to flashback.
Vapors are heavier than air and may spread along floors.
Development of hazardous combustion gases or vapours possible in the event of fire.
Forms explosive mixtures with air at ambient temperatures.
Combustible.
Pay attention to flashback.
Vapors are heavier than air and may spread along floors.
Development of hazardous combustion gases or vapours possible in the event of fire.
Forms explosive mixtures with air at ambient temperatures.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
3
3
0
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 3 | Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains. Risk of explosion.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ).
Dispose of properly. Clean up affected area.
Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
Advice on protection against fire and explosionKeep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsKeep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition.
Storage class
Storage class (TRGS 510): 3: Flammable liquids
8.1 Control parameters
Ingredients with workplace control parametersContains no substances with occupational exposure limit values.
8.2 Exposure controls
Appropriate engineering controlsImmediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles
Skin protection
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: butyl-rubber
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Butoject® (KCL 898)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.4 mm
Break through time: 10 min
Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M)
Internet: www.kcl.de).
Full contact
Material: butyl-rubber
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Butoject® (KCL 898)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.4 mm
Break through time: 10 min
Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M)
Body Protection
Flame retardant antistatic protective clothing.
Respiratory protection
required when vapours/aerosols are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Control of environmental exposure
Do not let product enter drains. Risk of explosion.
Information on basic physicochemical properties
- a) Physical stateliquid
- b) ColorClear colorless to very slightly yellow
- c) OdorNo data available
- d) Melting point/freezing pointMelting point: -68.3 °C
- e) Initial boiling point and boiling range114 °C - lit.
- f) Flammability (solid, gas)No data available
- g) Upper/lower flammability or explosive limits1.7%(V)
- h) Flash point21 °C - closed cup
- i) Autoignition temperatureNo data available
- j) Decomposition temperatureNo data available
- k) pHNo data available
- l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: No data available - m) Water solubilityFully miscible in water.
- n) Partition coefficient n-octanol/waterNo data available
- o) Vapor pressureNo data available
- p) Density0.849 g/cm3 at 25 °C - lit.
- Relative density0.849 g/mL at 25 °C(lit.)
- q) Relative vapor densityNo data available
- r) Particle characteristicsNo data available
- s) Explosive propertiesNo data available
- t) Oxidizing propertiesnone
- Solubility185g/l
9.2 Other safety information
No data available
10.1 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.2 Possibility of hazardous reactions
Violent reactions possible with:
Oxidizing agents
Bases
Oxidizing agents
Bases
10.3 Conditions to avoid
Warming.
10.4 Incompatible materials
No data available
10.5 Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityLD50 Oral - Rat - female - 500 - 2,000 mg/kg (OECD Test Guideline 423)
Remarks: (ECHA)
Inhalation: No data available
LD50 Dermal - Rat - > 2,000 mg/kg (OECD Test Guideline 402)
Remarks: (ECHA)
Skin corrosion/irritation
Remarks: (ECHA)
Inhalation: No data available
LD50 Dermal - Rat - > 2,000 mg/kg (OECD Test Guideline 402)
Remarks: (ECHA)
Skin - Rabbit
Result: Corrosive - 4 h (OECD Test Guideline 404)
Remarks: (ECHA)
Serious eye damage/eye irritation
Result: Corrosive - 4 h (OECD Test Guideline 404)
Remarks: (ECHA)
Remarks: Causes serious eye damage.
Respiratory or skin sensitization
Buehler Test - Guinea pig
Result: negative (OECD Test Guideline 406)
Remarks: (ECHA)
Germ cell mutagenicity
Result: negative (OECD Test Guideline 406)
Remarks: (ECHA)
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Remarks: (ECHA)
Test Type: Chromosome aberration test in vitro
Test system: Chinese hamster fibroblasts
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Remarks: (ECHA)
Carcinogenicity
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Remarks: (ECHA)
Test Type: Chromosome aberration test in vitro
Test system: Chinese hamster fibroblasts
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Remarks: (ECHA)
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
RTECS: KM5648000
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
After absorption of large quantities:
Lung edema
No description of any further symptoms is avaiable.
Other information
The following applies to ketones in general: when vapours/aerosols occur, mucosal irritations, coughing, and dyspnoea after inhalation. The absorption of large quantities leads to: CNS depression (narcosis). Repeated skin contact leads to a degreasing effect, with secondary inflammation possible. Toxic effects on the liver and kidneys cannot be excluded after high doses. The inhalation of droplets may result in the formation of oedemas in the respiratory tract.
Further data:
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
After absorption of large quantities:
Lung edema
No description of any further symptoms is avaiable.
Other information
The following applies to ketones in general: when vapours/aerosols occur, mucosal irritations, coughing, and dyspnoea after inhalation. The absorption of large quantities leads to: CNS depression (narcosis). Repeated skin contact leads to a degreasing effect, with secondary inflammation possible. Toxic effects on the liver and kidneys cannot be excluded after high doses. The inhalation of droplets may result in the formation of oedemas in the respiratory tract.
Further data:
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
12.1 Toxicity
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - > 1,000 mg/l - 48 h and other aquatic (OECD Test Guideline 202) invertebrates Remarks: (ECHA)
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 43 % - Not readily biodegradable.
(OECD Test Guideline 301C)
Remarks: (ECHA)
Result: 43 % - Not readily biodegradable.
(OECD Test Guideline 301C)
Remarks: (ECHA)
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
We have no quantitative data concerning the ecological effects of this product.
Further information on ecology
Discharge into the environment must be avoided.
Further information on ecology
Discharge into the environment must be avoided.
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Offer surplus and non-recyclable solutions to a licensed disposal company.
14.1 UN number
ADR/RID: 2924
IMDG: 2924
IATA-DGR: 2924
IMDG: 2924
IATA-DGR: 2924
14.2 UN proper shipping name
ADR/RID: FLAMMABLE LIQUID, CORROSIVE, N.O.S. (Cyclopropyl methyl ketone) (Cyclopropyl methyl ketone)
IMDG: FLAMMABLE LIQUID, CORROSIVE, N.O.S. (Cyclopropyl methyl ketone) (Cyclopropyl methyl ketone)
IATA-DGR: Flammable liquid, corrosive, n.o.s. (Cyclopropyl methyl ketone) (Cyclopropyl methyl ketone)
IMDG: FLAMMABLE LIQUID, CORROSIVE, N.O.S. (Cyclopropyl methyl ketone) (Cyclopropyl methyl ketone)
IATA-DGR: Flammable liquid, corrosive, n.o.s. (Cyclopropyl methyl ketone) (Cyclopropyl methyl ketone)
14.3 Transport hazard class(es)
ADR/RID: 3 (8)
IMDG: 3 (8)
IATA-DGR: 3 (8)
IMDG: 3 (8)
IATA-DGR: 3 (8)
14.4 Packaging group
ADR/RID: II
IMDG: II
IATA-DGR: II
IMDG: II
IATA-DGR: II
14.5 Environmental hazards
ADR/RID: no
IMDG Marine pollutant: no
IATA-DGR: no
IMDG Marine pollutant: no
IATA-DGR: no
14.6 Special precautions for user
Based on chemical properties, choose appropriate tools and conditions of transport.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
14.7 Incompatible materials
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulatory information
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Regulation of Environmental Management on the First Import of Chemicals and the Import and Export of Toxic Chemicals
China Severely Restricted Toxic Chemicals for : Listed
Import and Export
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Regulation of Environmental Management on the First Import of Chemicals and the Import and Export of Toxic Chemicals
China Severely Restricted Toxic Chemicals for : Listed
Import and Export
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.