Chemical Safety Data Sheet MSDS / SDS

Dimethyl fumarate

Revision Date:2024-11-09Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: Dimethyl fumarate
  • CBnumber: CB6712800
  • CAS: 624-49-7
  • EINECS Number: 210-849-0
  • Synonyms: DIMETHYL FUMARATE,fumaric acid dimethyl ester

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

  • Symbol(GHS)
  • Signal wordWarning
Precautionary statements
P405 Store locked up.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
Hazard statements
H411 Toxic to aquatic life with long lasting effects
H335 May cause respiratory irritation
H319 Causes serious eye irritation
H317 May cause an allergic skin reaction
H315 Causes skin irritation
H312 Harmful in contact with skin
H303 May be harmfulif swallowed

SECTION 3: Composition/information on ingredients

Substance

  • Product name: Dimethyl fumarate
  • Synonyms: DIMETHYL FUMARATE,fumaric acid dimethyl ester
  • CAS: 624-49-7
  • EC number: 210-849-0
  • MF: C6H8O4
  • MW: 144.13

SECTION 4: First aid measures

Description of first aid measures

General advice
Consult a physician. Show this material safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from the substance or mixture

Carbon oxides Combustible.

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

Further information

No data available

NFPA 704

1
0
0
HEALTH 1 Exposure would cause irritation with only minor residual injury (e.g. acetone, sodium bromate, potassium chloride)
FIRE 0 Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride)
REACT 0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up

Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols.

Advice on protection against fire and explosion

Provide appropriate exhaust ventilation at places where dust is formed.

Hygiene measures

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Keep container tightly closed in a dry and well-ventilated place. Store in cool place.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits
Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment
Eye/face protection

Face shield and safety glasses Use equipment for eye protection tested and

approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact

with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.

Full contact

Material: Nitrile rubber

Minimum layer thickness: 0,11 mm Break through time: 480 min

Material tested:Dermatril? (KCL 740 / Aldrich Z677272, Size M)

Splash contact Material: Nitrile rubber

Minimum layer thickness: 0,11 mm Break through time: 480 min

Material tested:Dermatril? (KCL 740 / Aldrich Z677272, Size M)

data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374

If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • Appearancewhite solid
  • Odourodorless
  • Odour ThresholdNo data available d) pH 4,0 - 6,0 at 10 g/l at 20 °C suspension Melting point/freezing point Melting point: 102 °C Initial boiling point 192 - 193 °C - lit. and boiling range Flash point No data available Evaporation rate No data available Flammability (solid, gas) Upper/lower flammability or explosive limits No data available No data available Vapour pressure 5 hPa at 25 °C - (calculated) Vapour density No data available Density 1,0283 g/cm3 at 20 °C Relative density No data available Water solubility 1,6 g/l at 20 °C Partition coefficient: n-octanol/water Autoignition temperature Decomposition temperature No data available No data available No data available Viscosity Viscosity, kinematic: No data available Viscosity, dynamic: No data available Explosive properties No data available Oxidizing properties No data available
  • Melting point/freezing pointMelting point: 102 °C
  • Initial boiling point and boiling range192 - 193 °C - lit.
  • Flash point192-193 °C (lit.)
  • Evaporation rate192-193°C
  • Flammability (solid, gas)No data available
  • Upper/lower flammability or explosive limitsNo data available
  • Vapour pressure 5 hPa at 25 °C - (calculated)
  • Vapour density 5 hPa (25 °C)
  • Relative density1,0283 g/cm3 at 20 °C No data available
  • Water solubility1,6 g/l at 20 °C
  • Partition coefficient: n-octanol/water1.6g/l
  • Autoignition temperatureNo data available
  • Decomposition temperatureNo data available
  • ViscosityViscosity, kinematic: No data available Viscosity, dynamic: No data available
  • Explosive propertiesNo data available
  • Oxidizing propertiesNo data available

Other safety information

No data available

SECTION 10: Stability and reactivity

Reactivity

No data available

Chemical stability

Stable under recommended storage conditions.

Possibility of hazardous reactions

No data available

Conditions to avoid

No data available

Incompatible materials

acids, Bases, Strong oxidizing agents, Reducing agents

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity
Oral
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract
Inhalation: Rapid absorption.
LD50 Dermal - Rabbit - 1.250 mg/kg Remarks: (RTECS)
Skin corrosion/irritation
Skin - Rabbit Result: Irritations Remarks: (RTECS)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Severe irritations Remarks: (RTECS)
Respiratory or skin sensitization
Remarks: (Lit.)
Germ cell mutagenicity
Test Type: Mutagenicity (mammal cell test): micronucleus.
Result: negative Remarks: (Lit.)
Carcinogenicity
No data available
Animal testing did not show any effects on fertility. Developmental Toxicity- Rat
Remarks: No significant adverse effects were reported
Specific target organ toxicity - single exposure
May cause respiratory irritation.
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
Toxicity
LD50 orally in Rabbit: 2240 mg/kg LD50 dermal Rabbit 1250 mg/kg

SECTION 12: Ecological information

Toxicity

Toxicity to fish
NOEC - Pimephales promelas (fathead minnow) - 0,0457 mg/l (OECD Test Guideline 210)

Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - 1,2 mg/l - 48 h Remarks: (own results)


NOEC - Daphnia magna (Water flea) - 0,0559 mg/l (OECD Test Guideline 211)

Toxicity to bacteria
EC50 - activated sludge - 153,6 mg/l - 3 h

(OECD Test Guideline 209)

Persistence and degradability

Biodegradability Result: 76 % - Readily biodegradable.

(OECD Test Guideline 301D)

Bioaccumulative potential

No bioaccumulation is to be expected (log Pow <= 4).

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

Toxic to aquatic life with long lasting effects. Discharge into the environment must be avoided.

SECTION 13: Disposal considerations

Waste treatment methods

Product

Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or

mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Waste material must be disposed of in accordance with the Directive on waste 2008/98/EC as well as other national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.

Contaminated packaging

Dispose of as unused product.

SECTION 14: Transport information

UN number

ADR/RID: 3077 IMDG: 3077 IATA: 3077

UN proper shipping name

ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (dimethyl

fumarate)

IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (dimethyl

fumarate)

IATA: Environmentally hazardous substance, solid, n.o.s. (dimethyl fumarate)

Transport hazard class(es)

ADR/RID: 9 IMDG: 9 IATA: 9

Packaging group

ADR/RID: III IMDG: III IATA: III

Environmental hazards

ADR/RID: yes IMDG Marine pollutant: yes IATA: yes

Special precautions for user

Further information

EHS-Mark required (ADR 2.2.9.1.10, IMDG code 2.10.3) for single packagings and combination packagings containing inner packagings with Dangerous Goods > 5L for liquids

or > 5kg for solids.Packages smaller than or equal to 5 kg / L , not dangerous goods of Class 9

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals
China Catalog of Hazardous chemicals 2015:Not Listed. website: https://www.mem.gov.cn/
Measures for Environmental Management of New Chemical Substances
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/
EC Inventory:Listed.
European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/
Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr
New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/
Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/
United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/
Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/

SECTION 16: Other information

Abbreviations and acronyms

  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • CAS: Chemical Abstracts Service
  • EC50: Effective Concentration 50%
  • IATA: International Air Transportation Association
  • IMDG: International Maritime Dangerous Goods
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • STEL: Short term exposure limit
  • TWA: Time Weighted Average

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

Products containing more than 0.1% Dimethylfumarate are banned from the market in EU countries.
Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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