Chemical Safety Data Sheet MSDS / SDS
Ethyl Azidoacetate
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: Ethyl Azidoacetate
- CBnumber: CB7334391
- CAS: 637-81-0
- EINECS Number: 211-301-3
- Synonyms: ethyl 2-azidoacetate
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
P308+P313 IF exposed or concerned: Get medical advice/attention.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P201 Obtain special instructions before use.
Hazard statements
H351 Suspected of causing cancer
H336 May cause drowsiness or dizziness
H319 Causes serious eye irritation
H315 Causes skin irritation
Substance
- Product name: Ethyl Azidoacetate
- Synonyms: ethyl 2-azidoacetate
- CAS: 637-81-0
- EC number: 211-301-3
- MF: C4H7N3O2
- MW: 129.12
4.1 Description of first-aid measures
General adviceShow this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.
In case of eye contact
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
4.4 Notes to physician
No data available
5.1 Extinguishing media
Suitable extinguishing mediaFoam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Nitrogen oxides (NOx)
Hydrogen chloride gas
Mixture with combustible ingredients.
Development of hazardous combustion gases or vapours possible in the event of fire.
Nitrogen oxides (NOx)
Hydrogen chloride gas
Mixture with combustible ingredients.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
2
2
0
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 2 | Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ).
Dispose of properly. Clean up affected area.
Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
Advice on safe handlingWork under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsTightly closed. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons.
Store under inert gas.
Storage class
Store under inert gas.
Storage class (TRGS 510): 6.1C: Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
8.1 Control parameters
Ingredients with workplace control parameters| ['Component', 'CAS-No.', 'Value', 'Control\nparameters', 'Basis'] | ['Dichloromethane', '75-09-2', 'PC-TWA', '200 mg/m3', 'Occupational exposure limits for\nhazardous agents in the\nworkplace - Chemical\nhazardous agents.'] | ['', 'Remarks', 'G2A - Probably carcinogenic to humans', None, None] |
|---|
| ['Component', 'CAS-No.', 'Parameters', 'Value', 'Biological\nspecimen', 'Basis'] | ['', '75-09-2', 'dichloromet\nhane', '0.3 mg/l', 'Urine', 'China. Biological\nOccupational\nExposure Indices'] | ['', 'Remarks', 'End of shift', None, None, None] |
|---|
8.2 Exposure controls
Appropriate engineering controlsImmediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Splash contact
Material: Fluorinated rubber
Minimum layer thickness: 0.7 mm
Break through time: 120 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Body Protection
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Splash contact
Material: Fluorinated rubber
Minimum layer thickness: 0.7 mm
Break through time: 120 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
protective clothing
Respiratory protection
required when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Control of environmental exposure
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Do not let product enter drains.
Information on basic physicochemical properties
- a) Physical stateliquid
- b) ColorColourless to Pale Yellow
- c) OdorNo data available
- d) Melting point/freezing pointNo data available
- e) Initial boiling point and boiling range44-46°C 2mm
- f) Flammability (solid, gas)No data available
- g) Upper/lower flammability or explosive limitsNo data available
- h) Flash point25 °C
- i) Autoignition temperatureNo data available
- j) Decomposition temperatureNo data available
- k) pHNo data available
- l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: No data available - m) Water solubilityNo data available
- n) Partition coefficient n-octanol/waterNo data available
- o) Vapor pressureNo data available
- p) Density1.12g/ml
- Relative density1.12g/ml
- q) Relative vapor densityNo data available
- r) Particle characteristicsNo data available
- s) Explosive propertiesNot classified as explosive.
- t) Oxidizing propertiesnone
- SolubilityChloroform (Sparingly), Ethyl Acetate (Slightly)
9.2 Other safety information
No data available
10.1 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.2 Possibility of hazardous reactions
No data available
10.3 Conditions to avoid
Heat.
no information available
no information available
10.4 Incompatible materials
Alkali metals
10.5 Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Mixture Acute toxicityOral: No data available
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract.
Symptoms: Possible symptoms:, mucosal irritations
Dermal: No data available
Skin corrosion/irritation
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract.
Symptoms: Possible symptoms:, mucosal irritations
Dermal: No data available
Remarks: Mixture causes skin irritation.
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye irritation.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Evidence of a carcinogenic effect.
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Mixture may cause drowsiness or dizziness.
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Prolonged or repeated contact with skin may cause:, defatting, Dermatitis, Contact with eyes can cause:, Redness, Blurred vision, Provokes tears., Effects due to ingestion may include:, Gastrointestinal discomfort, Central nervous system depression, Paresthesia.,
Drowsiness, Convulsions
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
Handle in accordance with good industrial hygiene and safety practice.
Components Dichloromethane
Drowsiness, Convulsions
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
Handle in accordance with good industrial hygiene and safety practice.
Acute toxicity
LD50 Oral - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 401)
LC50 Inhalation - Mouse - 4 h - 86 mg/l - vapor
Remarks: (ECHA)
Symptoms: Possible damages:, mucosal irritations
LD50 Dermal - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 402)
Skin corrosion/irritation
LC50 Inhalation - Mouse - 4 h - 86 mg/l - vapor
Remarks: (ECHA)
Symptoms: Possible damages:, mucosal irritations
LD50 Dermal - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 402)
Skin - Rabbit
Result: Irritations - 4 h (OECD Test Guideline 404)
Remarks: Repeated or prolonged exposure may cause skin irritation and dermatitis, due to degreasing properties of the product.
Serious eye damage/eye irritation
Result: Irritations - 4 h (OECD Test Guideline 404)
Remarks: Repeated or prolonged exposure may cause skin irritation and dermatitis, due to degreasing properties of the product.
Eyes - Rabbit
Result: Eye irritation
Remarks: (ECHA)
Remarks: Risk of corneal clouding.
Respiratory or skin sensitization
Result: Eye irritation
Remarks: (ECHA)
Remarks: Risk of corneal clouding.
Local lymph node assay (LLNA) - Mouse
Result: negative (OECD Test Guideline 429)
Germ cell mutagenicity
Result: negative (OECD Test Guideline 429)
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Result: positive
Test Type: Ames test
Test system: Salmonella typhimurium
Result: positive
Method: OECD Test Guideline 474
Species: Mouse - male and female - Bone marrow
Result: negative
Carcinogenicity
Test system: Chinese hamster ovary cells
Result: positive
Test Type: Ames test
Test system: Salmonella typhimurium
Result: positive
Method: OECD Test Guideline 474
Species: Mouse - male and female - Bone marrow
Result: negative
Suspected of causing cancer.
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Inhalation - May cause drowsiness or dizziness. - Central nervous system
Acute inhalation toxicity - Possible damages:, mucosal irritations
Specific target organ toxicity - repeated exposure Aspiration hazard
Acute inhalation toxicity - Possible damages:, mucosal irritations
Classified based on available data. For more details, see section 2
12.1 Toxicity
MixtureNo data available
12.2 Persistence and degradability
No data available
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
No data available
Components Dichloromethane
Toxicity to fish flow-through test LC50 - Pimephales promelas (fathead minnow) - 193.00 mg/l - 96 h
Remarks: (ECHA)
Toxicity to daphnia static test LC50 - Daphnia magna (Water flea) - 27 mg/l - 48 h and other aquatic (US-EPA) invertebrates
Toxicity to bacteria static test EC50 - activated sludge - 2,590 mg/l - 40 min (OECD Test Guideline 209)
Toxicity to flow-through test LC50 - Pimephales promelas (fathead fish(Chronic toxicity) minnow) - 471 mg/l - 8 d
Remarks: (ECHA)
Remarks: (ECHA)
Toxicity to daphnia static test LC50 - Daphnia magna (Water flea) - 27 mg/l - 48 h and other aquatic (US-EPA) invertebrates
Toxicity to bacteria static test EC50 - activated sludge - 2,590 mg/l - 40 min (OECD Test Guideline 209)
Toxicity to flow-through test LC50 - Pimephales promelas (fathead fish(Chronic toxicity) minnow) - 471 mg/l - 8 d
Remarks: (ECHA)
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Offer surplus and non-recyclable solutions to a licensed disposal company.
14.1 UN number
ADR/RID: 1593
IMDG: 1593
IATA-DGR: 1593
IMDG: 1593
IATA-DGR: 1593
14.2 UN proper shipping name
ADR/RID: DICHLOROMETHANE,SOLUTION
IMDG: DICHLOROMETHANE,SOLUTION
IATA-DGR: Dichloromethane,SOLUTION
IMDG: DICHLOROMETHANE,SOLUTION
IATA-DGR: Dichloromethane,SOLUTION
14.3 Transport hazard class(es)
ADR/RID: 6.1
IMDG: 6.1
IATA-DGR: 6.1
IMDG: 6.1
IATA-DGR: 6.1
14.4 Packaging group
ADR/RID: III
IMDG: III
IATA-DGR: III
IMDG: III
IATA-DGR: III
14.5 Environmental hazards
ADR/RID: no
IMDG Marine pollutant: no
IATA-DGR: no
IMDG Marine pollutant: no
IATA-DGR: no
14.6 Special precautions for user
Based on chemical properties, choose appropriate tools and conditions of transport.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
14.7 Incompatible materials
Alkali metals
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulatory information
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number : 01-2119480404-41-XXXX
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number : 01-2119480404-41-XXXX
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.
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