Chemical Safety Data Sheet MSDS / SDS

ISOPROPYLMAGNESIUM BROMIDE

Revision Date:2026-03-21Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: ISOPROPYLMAGNESIUM BROMIDE
  • CBnumber: CB5334382
  • CAS: 920-39-8
  • EINECS Number: 213-056-8
  • Synonyms: bromo(1-methylethyl)magnesium;ISOPROPYLMAGNESIUM BROMIDE

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 010-86108875

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

  • Symbol(GHS)
  • Signal wordDanger
Precautionary statements
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P231+P232 Handle under inert gas. Protect from moisture.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
Hazard statements
H314 Causes severe skin burns and eye damage
H302 Harmful if swallowed
H261 In contact with water releases flammable gas
H225 Highly Flammable liquid and vapour

SECTION 3: Composition/information on ingredients

Substance

  • Product name: ISOPROPYLMAGNESIUM BROMIDE
  • Synonyms: bromo(1-methylethyl)magnesium;ISOPROPYLMAGNESIUM BROMIDE
  • CAS: 920-39-8
  • EC number: 213-056-8
  • MF: C3H7BrMg
  • MW: 147.3

SECTION 4: First aid measures

General advice

First aiders need to protect themselves. Show this safety data sheet to the doctor in attendance.

If inhaled

After inhalation: fresh air. Call in physician.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.

In case of eye contact

After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.

If swallowed

After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Call a physician immediately. Do not attempt to neutralise.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11

Protection of first-aiders

For personal protection see section 8.

Notes to physician

No data available

SECTION 5: Firefighting measures

Suitable extinguishing media

Carbon dioxide (CO2) Dry powder

Unsuitable extinguishing media

Water Foam

Specific hazards during fire fighting

Combustible. Pay attention to flashback. Vapours are heavier than air and may spread along floors. May not get in touch with: Water Development of hazardous combustion gases or vapours possible in the event of fire. Forms explosive mixtures with air at ambient temperatures.

Hazardous combustion products

Carbon oxides

Specific extinguishing methods

Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.

Special protective equipment for fire-fighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

NFPA 704

3
3
2
W
HEALTH 3 Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
FIRE 3 Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone)
REACT 2 Undergoes violent chemical change at elevated temperatures and pressures, reacts violently with water, or may form explosive mixtures with water (e.g. white phosphorus, potassium, sodium)
SPEC. HAZ. W

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapours, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: For personal protection see section 8.

Environmental precautions

Do not let product enter drains. Risk of explosion.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ). Dispose of properly. Clean up affected area.

SECTION 7: Handling and storage

Handling

Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition. Take precautionary measures against static discharge.
Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols. Keep workplace dry. Do not allow product to come into contact with water.
Avoidance of contact
Strong bases Strong oxidizing agents Strong acids

Storage

Further information on storage conditions
Tightly closed. Keep away from heat and sources of ignition.
Materials to avoid
Never allow product to get in contact with water during storage.
Storage class
4.3, Hazardous materials, which set free flammable gases upon contact with water
Recommended storage temperature
Recommended storage temperature see product label.
Further information on storage stability
Handle and store under inert gas. Dry residue is explosive. Test for peroxide formation periodically and before distillation.
Packaging material
Suitable material: Sure-Seal Bottles

SECTION 8: Exposure controls/personal protection

Ingredients with workplace control parameters

Contains no substances with occupational exposure limit values.

Engineering measures

No data available

Personal protective equipment

Respiratory protection
required when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type
Filter type ABEK
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Tightly fitting safety goggles
Skin and body protection
Flame retardant antistatic protective clothing.
Hand protection
Material
butyl-rubber
Break through time
10 min
Glove thickness
0.3 mm
Protective index
Splash contact
Manufacturer
Butoject® (KCL 897 / Aldrich Z677647, Size M)
Manufacturer
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
Remarks
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • SolubilityMiscible with tetrahydorfuran and diethyl ether. Immiscible with hydrocarbons.
  • Physical stateSolution
  • Oxidizing propertiesnone
  • Particle characteristics Particle sizeNo data available
  • Molecular weight147.30 g/mol
  • Explosive propertiesNot classified as explosive.
  • Flow timeNo data available
  • Viscosity, kinematicNo data available
  • Viscosity, dynamicNo data available
  • Decomposition temperatureNo data available
  • Autoignition temperatureNo data available
  • Partition coefficient: n-octanol/waterNo data available
  • Water solubilityNo data available
  • Density1.112 g/cm3
  • Relative density0.982 g/mL at 25 °C
  • Relative vapor densityNo data available
  • Vapor pressureNo data available
  • Lower explosion limit / Lower flammability limitNo data available
  • Upper explosion limit / Upper flammability limitNo data available
  • Burning rateNo data available
  • Flammability (liquids)No data available
  • Flammability (solid, gas)No data available
  • Evaporation rateNo data available
  • Flash point< -25 °C
  • Boiling point/boiling range148-154℃
  • Melting point/ rangeNo data available
  • pHNo data available
  • Odor ThresholdNo data available
  • OdorNo data available
  • ColorClear dark brown or dark gray
  • Appearanceliquid

SECTION 10: Stability and reactivity

Reactivity

Formation of peroxides possible. Vapours may form explosive mixture with air.

Chemical stability

Sensitive to air. sensitive to moisture

Possibility of hazardous reactions

No data available

Conditions to avoid

Exposure to air. Warming. Moisture.

Incompatible materials

Strong bases Strong oxidizing agents Strong acids

Hazardous decomposition products

Peroxides : In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Mixture Acute toxicity
Acute toxicity estimate Oral - 833.33 mg/kg (Calculation method)
Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the oesophagus and the stomach.
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract
Dermal: No data available
Skin corrosion/irritation
Remarks: Mixture causes burns.
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye damage.
Risk of blindness!
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2

11.2 Additional Information

Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache,
Nausea
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Components 2-Methyltetrahydrofuran
Acute toxicity
LD50 Oral - Rat - female - > 300 - 2,000 mg/kg (OECD Test Guideline 420)
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oe- sophagus and gastrointestinal tract., Risk of aspiration upon vomiting., As- piration may cause pulmonary oedema and pneumonitis.
Symptoms: Possible damages:, mucosal irritations
LD50 Dermal - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 402)
Skin corrosion/irritation
Skin - In vitro study
Result: irritating - 15 min (OECD Test Guideline 439)
Serious eye damage/eye irritation
Eyes - In vitro study
Result: Corrosive - 10 min (OECD Test Guideline 437)
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: negative (OECD Test Guideline 429)
Germ cell mutagenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Mouse lymphoma test
Result: negative
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Acute oral toxicity - Irritations of mucous membranes in the mouth, phar- ynx, oesophagus and gastrointestinal tract., Risk of aspiration upon vomit- ing., Aspiration may cause pulmonary oedema and pneumonitis.
Acute inhalation toxicity - Possible damages:, mucosal irritations
Specific target organ toxicity - repeated exposure Aspiration hazard
Classified based on available data. For more details, see section 2
Bromo(1-methylethyl)magnesium
Acute toxicity
Oral: No data available
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Remarks: No data available
Serious eye damage/eye irritation
Remarks: No data available
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2

SECTION 12: Ecological information

Ecotoxicity

Components:

2-Methyltetrahydrofuran:

Toxicity to fish
LC50 (Oncorhynchus mykiss (rainbow trout)): > 100 mg/l End point: mortality Exposure time: 96 h Test Type: semi-static test Analytical monitoring: yes Method: OECD Test Guideline 203 GLP: yes
Toxicity to daphnia and other aquatic invertebrates
EC50 (Daphnia magna (Water flea)): > 139 mg/l End point: Immobilization Exposure time: 48 h Test Type: semi-static test Analytical monitoring: yes Method: OECD Test Guideline 202 GLP: yes
Toxicity to algae/aquatic plants
ErC50 (Desmodesmus subspicatus (green algae)): > 104 mg/l Exposure time: 72 h Test Type: static test Analytical monitoring: yes Method: OECD Test Guideline 201 GLP: yes
Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity)
NOEC (Daphnia magna (Water flea)): >= 120 mg/l End point: mortality Exposure time: 21 d Test Type: semi-static test Analytical monitoring: yes Method: OECD Test Guideline 211 GLP: yes
Toxicity to microorganisms
EC50 (activated sludge): > 1,000 mg/l Exposure time: 3 h Test Type: static test Method: OECD Test Guideline 209 GLP: yes

Persistence and degradability

Components:

2-Methyltetrahydrofuran:

Biodegradability
aerobic Inoculum: activated sludge Result: Not readily biodegradable. Biodegradation: 2 % Exposure time: 28 d Method: OECD Test Guideline 301D GLP: yes

Bioaccumulative potential

Components:

2-Methyltetrahydrofuran:

Partition coefficient: noctanol/water
log Pow: 1.35 Method: (calculated) Remarks: Bioaccumulation is not expected. (Lit.)

Mobility in soil

No data available

Other adverse effects

Components:

2-Methyltetrahydrofuran:

Additional ecological information
Discharge into the environment must be avoided.

SECTION 13: Disposal considerations

Disposal methods

Waste from residues
Offer surplus and non-recyclable solutions to a licensed disposal company.

SECTION 14: Transport information

International Regulations

IATA-DGR

UN/ID No. : UN 3399
Proper shipping name : Organometallic substance, liquid, water-reactive, flammable (Bromo(1-methylethyl)magnesium, 2Methyltetrahydrofuran)
Class : 4.3
Subsidiary risk : 3
Packing group : II
Labels : Division 4.3 - Substances which in contact with water emit flammable gases, Class 3 - Flammable liquids
Packing instruction (cargo aircraft) : 494
Packing instruction (passenger aircraft) : 493

IMDG-Code

UN number : UN 3399
Proper shipping name : ORGANOMETALLIC SUBSTANCE, LIQUID, WATERREACTIVE, FLAMMABLE (Bromo(1-methylethyl)magnesium, 2Methyltetrahydrofuran)
Class : 4.3
Subsidiary risk : 3
Packing group : II
Labels : 4.3 (3)
EmS Code : F-G, S-N
Marine pollutant : no

Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

Not applicable for product as supplied.

National Regulations

JT/T 617

UN number : UN 3399
Proper shipping name : ORGANOMETALLIC SUBSTANCE, LIQUID, WATERREACTIVE, FLAMMABLE (Bromo(1-methylethyl)magnesium, 2Methyltetrahydrofuran)
Class : 4.3
Subsidiary risk : 3
Packing group : II
Labels : 4.3 (3)
Environmentally hazardous : no

Special precautions for user

The transport classification(s) provided herein are for informational purposes only, and solely based upon the properties of the unpackaged material as it is described within this Safety Data Sheet. Transportation classifications may vary by mode of transportation, package sizes, and variations in regional or country regulations.

SECTION 15: Regulatory information

Catalogue of Hazardous Chemicals : This product is not listed in the catalogue of hazardous chemicals, but it meets the definition of hazardous chemicals and its principles of determination.

National regulatory information

Regulations on Safety Management of Hazardous Chemicals

Identification of Major Hazard Installations for Hazardous Chemicals (GB 18218)

No. / Code Chemical name / Category Threshold quantity

W5.3 Flammable liquids 1,000 t

W11 Substances and mixtures which in 200 t contact with water, emit flammable gases

Hazardous Chemicals for Priority Management

Not listed under SAWS

China. List of Explosive Precursors

Not applicable

Regulations on Labour Protection in Workplaces where Toxic Substances are Used

Catalogue of Highly Toxic Chemicals

Not listed

Regulation of Environmental Management on the First Import of Chemicals and the Import and Export of Toxic Chemicals

China Severely Restricted Toxic Chemicals for Import and Export

Not listed

SECTION 16: Other information

Full text of other abbreviations

AIIC - Australian Inventory of Industrial Chemicals
ANTT - National Agency forTransport by Land of Brazil
ASTM - American Society for the Testing of Materials
bw - Body weight
CMR - Carcinogen, Mutagen or Reproductive Toxicant
DIN -Standard of the German Institute for Standardisation
DSL - Domestic SubstancesList (Canada)
ECx - Concentration associated with x% response
ELx - Loading rate associated with x% response
EmS - Emergency Schedule
ENCS - Existing and NewChemical Substances (Japan)
ErCx - Concentration associated with x% growth rate response
ERG - Emergency Response Guide
GHS - Globally Harmonised System
GLP - Good Laboratory Practice
IARC - International Agency for Research on Can- cer
IATA - International Air Transport Association
IBC - International Code for theConstruction and Equipment of Ships carrying Dangerous Chemicals in Bulk
IC50 -Half maximal inhibitory concentration
ICAO - International Civil Aviation Organiza- tion
IECSC - Inventory of Existing Chemical Substances in China
IMDG - Interna- tional Maritime Dangerous Goods
IMO - International Maritime Organisation
ISHL -Industrial Safety and Health Law (Japan)
ISO - International Organisation forStandardisation
KECI - Korea Existing Chemicals Inventory
LC50 - Lethal Concen- tration to 50 % of a test population
LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose)
MARPOL - International Convention for the Prevention of Pol- lution from Ships
MERCOSUR - The Agreement for the Facilitation of the Transport of Dangerous Goods
n.o.s. - Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC - No Observed (Adverse) Effect Concentration
NO(A)EL - No Observed (Adverse) Ef- fect Level
NOELR - No Observable Effect Loading Rate
NOM - Official MexicanNorm
NTP - National Toxicology Program
NZIoC - New Zealand Inventory of Chem- icals
OECD - Organisation for Economic Co-operation and Development
OPPTS - Of- fice of Chemical Safety and Pollution Prevention
PBT - Persistent, Bioaccumulative and Toxic substance
PICCS - Philippines Inventory of Chemicals and Chemical Sub- stances
(Q)SAR - (Quantitative) Structure Activity Relationship
REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning theRegistration, Evaluation, Authorisation and Restriction of Chemicals
SADT - Self-Accelerating Decomposition Temperature
SDS - Safety Data Sheet
TCSI - TaiwanChemical Substance Inventory
TDG - Transportation of Dangerous Goods
TECI -Thailand Existing Chemicals Inventory
TSCA - Toxic Substances Control Act (UnitedStates)
UN - United Nations
UNRTDG - United Nations Recommendations on theTransport of Dangerous Goods
vPvB - Very Persistent and Very Bioaccumulative
WHMIS - Workplace Hazardous Materials Information System
Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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