Chemical Safety Data Sheet MSDS / SDS
Potassium clavulanate
Revision Date:2026-03-20Revision Number:1
Product identifier
- Product name: Potassium clavulanate
- CBnumber: CB2722502
- CAS: 61177-45-5
- EINECS Number: 262-640-9
- Synonyms: Clavulanate;CLAVULANATE POTASSIUM
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P403+P235 Store in a well-ventilated place. Keep cool.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P235 Keep cool.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
Hazard statements
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
H317 May cause an allergic skin reaction
H252 Self-heating in large quantities; may catch fire
H228 Flammable solid
Substance
- Product name: Potassium clavulanate
- Synonyms: Clavulanate;CLAVULANATE POTASSIUM
- CAS: 61177-45-5
- EC number: 262-640-9
- MF: C8H10KNO5
- MW: 239.27
Description of first aid measures
General information
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident.
After inhalation
Supply fresh air and to be sure call for a doctor.
In case of unconsciousness place patient stably in side position for transportation.
In case of unconsciousness place patient stably in side position for transportation.
After skin contact
Immediately wash with water and soap and rinse thoroughly.
After eye contact
Rinse opened eye for several minutes under running water.
After swallowing
Immediately call a doctor.
Information for doctor
Most important symptoms and effects, both acute and delayed
May cause anemia, cough, CNS depression, drowsiness, headache, heart damage, lassitude (weakness, exhaustion), liver damage, narcosis, reproductive effects, teratogenic effects.
No further relevant information available.
No further relevant information available.
Indication of any immediate medical attention and special treatment needed
No further relevant information available.
Extinguishing media
Suitable extinguishing agents
Use fire fighting measures that suit the environment.
A solid water stream may be inefficient.
A solid water stream may be inefficient.
Special hazards arising from the substance or mixture
No further relevant information available.
Advice for firefighters
Protective equipment
No special measures required.
NFPA 704
0
4
0
| HEALTH | 0 | Poses no health hazard, no precautions necessary and would offer no hazard beyond that of ordinary combustible materials | |
| FIRE | 4 | Will rapidly or completely vaporize at normal atmospheric pressure and temperature, or is readily dispersed in air and will burn readily. Includes pyrophoric substances. Flash point below room temperature at 22.8 °C (73 °F). (e.g. acetylene, propane, hydrogen gas) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Wear protective equipment. Keep unprotected persons away.
Environmental precautions
Do not allow to enter sewers/ surface or ground water.
Methods and material for containment and cleaning up
Dispose contaminated material as waste according to item 13.
Ensure adequate ventilation.
Ensure adequate ventilation.
Reference to other sections
See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
Protective Action Criteria for Chemicals
PAC-1
Substance is not listed.
PAC-2
Substance is not listed.
PAC-3
Substance is not listed.
Handling
Precautions for safe handling
Ensure good ventilation/exhaustion at the workplace.
Information about protection against explosions and fires
Keep ignition sources away - Do not smoke.
Conditions for safe storage, including any incompatibilities
Storage
Store in accordance with information listed on the product insert.
Requirements to be met by storerooms and receptacles
No special requirements.
Information about storage in one common storage facility
Not required.
Further information about storage conditions
Keep receptacle tightly sealed.
Specific end use(s)
No further relevant information available.
Additional information about design of technical systems
No further data; see item 7.
Control parameters
Components with limit values that require monitoring at the workplace
Not required.
Additional information
The lists that were valid during the creation were used as basis.
Exposure controls
Personal protective equipment
General protective and hygienic measures
Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Breathing equipment
In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use respiratory protective device that is independent of circulating air.
Protection of hands
Protective gloves
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
Material of gloves
The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer.
Penetration time of glove material
The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed.
Eye protection
Not required.
Information on basic physicochemical properties
- Other informationNo information available
- SOLUBILITYmiscible in: DMSO; PBS; DMF
- KinematicNot applicable.
- DynamicNot applicable.
- Partition coefficient (n-octanol/water)Not determined.
- WaterNot determined.
- Solubility in / Miscibility withFreely soluble in water, slightly soluble in ethanol (96 per cent), very slightly soluble in acetone.
- Evaporation RateNot applicable.
- Vapor DensityNot applicable.
- Relative DensityNot determined.
- DensityNot determined.
- Vapor PressureNot applicable.
- Explosion limitsLower: Not determined.
Upper: Not determined. - Danger of explosionNot determined.
- Auto ignitingNot determined.
- Decomposition temperatureNot determined.
- Flammability (solid,gas)Product is not flammable.
- Flash pointNot applicable.
- Boiling point/Boiling rangeUndetermined.
- Melting point/Melting rangeUndetermined.
- pHNot applicable.
- Odor ThresholdNot determined.
- Molecular Weight237.3 g/mol
- Structural FormulaC8H8NO5 K
- OdorCharacteristic
- ColorLight brown to brown
- Physical StateCrystalline
Reactivity
No further relevant information available.
Chemical stability
Thermal decomposition / conditions to be avoided
No decomposition if used according to specifications.
Possibility of hazardous reactions
No dangerous reactions known.
Conditions to avoid
No further relevant information available.
Incompatible materials
strong oxidizing agents, H2O
Hazardous decomposition products
carbon oxides, hydrogen cyanide, nitrogen oxides, potassium oxides
RTECS Number
RN6802700
Information on toxicological effects
Acute toxicity
LD/LC50 values that are relevant for classification:
| Route | Endpoint | Value |
|---|---|---|
| Oral | LD50 | 4,526 mg/kg (mouse) 7,936 mg/kg (rat) |
| Intraperitoneal | LD50 | 1,531 mg/kg (mouse) 1,399 mg/kg (rat) |
| Subcutaneous | LD50 | 2,185 mg/kg (mouse) 1,398 mg/kg (rat) |
Primary irritant effect
on the skin
No irritant effect.
on the eye
No irritating effect.
Sensitization
Sensitization
possible through inhalation.
Sensitization
possible through skin contact.
Additional toxicological information
Carcinogenic categories
IARC (International Agency for Research on Cancer)
Substance is not listed.
NTP (National Toxicology Program)
Substance is not listed.
OSHA-Ca (Occupational Safety & Health Administration)
Substance is not listed.
Toxicity
Aquatic toxicity
No further relevant information available.
Persistence and degradability
No further relevant information available.
Results of PBT and vPvB assessment
PBT:
Not applicable.
vPvB:
Not applicable.
Other adverse effects
No further relevant information available.
Waste treatment methods
Recommendation
Must not be disposed of together with household garbage. Do not allow product to reach sewage system.
Uncleaned packagings
Recommendation
Disposal must be made according to official regulations.
UN-Number
DOT, IMDG, IATA UN1325
UN proper shipping name
DOT Flammable solids, organic, n.o.s. (Clavulanate (potassium salt))
IMDG FLAMMABLE SOLID, ORGANIC, N.O.S. (Clavulanate (potassium salt))
IATA Flammable solid, organic, n.o.s. (Clavulanate (potassium salt))
IMDG FLAMMABLE SOLID, ORGANIC, N.O.S. (Clavulanate (potassium salt))
IATA Flammable solid, organic, n.o.s. (Clavulanate (potassium salt))
Transport hazard class(es)
DOTClass: 4.1 Flammable solids, self-reactive substances and
Label: 4.1
IMDG, IATA
Label: 4.1
Class: 4.1 Flammable solids, self-reactive substances and
Label: 4.1
Label: 4.1
Packing group
DOT, IMDG, IATA II
Environmental hazards
Not applicable.
Special precautions for user
Warning: Flammable solids, self-reactive substances and solid desensitised explosives
Hazard identification number (Kemler code)
40
EMS Number
F-A,S-G
Stowage Category
B
Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code
Not applicable.
Transport/Additional information
DOT:
Quantity limitations
On passenger aircraft/rail: 15 kg
On cargo aircraft only: 50 kg
On cargo aircraft only: 50 kg
IMDG:
Limited quantities (LQ)
1 kg
Excepted quantities (EQ)
Code: E2
Maximum net quantity per inner packaging: 30 g
Maximum net quantity per outer packaging: 500 g
Maximum net quantity per inner packaging: 30 g
Maximum net quantity per outer packaging: 500 g
IATA:
Remarks
When sold in quantities of less than or equal to 1 mL, or 1 g, with an Excepted Quantity Code of
E1, E2, E4, or E5, this item meets the De Minimis
Quantities exemption, per IATA 2.6.10.
Therefore packaging does not have to be labeled as
Dangerous Goods/Excepted Quantity.
E1, E2, E4, or E5, this item meets the De Minimis
Quantities exemption, per IATA 2.6.10.
Therefore packaging does not have to be labeled as
Dangerous Goods/Excepted Quantity.
UN "Model Regulation"
UN 1325 FLAMMABLE SOLID, ORGANIC, N.O.S.
(CLAVULANATE (POTASSIUM SALT)), 4.1, II
(CLAVULANATE (POTASSIUM SALT)), 4.1, II
Safety, health and environmental regulations/legislation specific for the substance or mixture
No further relevant information available.
Sara
| Section 355 (extremely hazardous substances): | Substance is not listed. |
| Section 313 (Specific toxic chemical listings): | Substance is not listed. |
| TSCA (Toxic Substances Control Act): | Substance is not listed. |
| Hazardous Air Pollutants: | Substance is not listed. |
Proposition 65
| Chemicals known to cause cancer: | Substance is not listed. |
| Chemicals known to cause reproductive toxicity for females: | Substance is not listed. |
| Chemicals known to cause reproductive toxicity for males: | Substance is not listed. |
| Chemicals known to cause developmental toxicity: | Substance is not listed. |
Chemicals known to cause cancer
Substance is not listed.
Chemicals known to cause reproductive toxicity for females
Substance is not listed.
Chemicals known to cause reproductive toxicity for males
Substance is not listed.
Chemicals known to cause developmental toxicity
Substance is not listed.
Carcinogenic categories
| EPA (Environmental Protection Agency): | Substance is not listed. |
TLV (Threshold Limit Value)
Substance is not listed.
NIOSH-Ca (National Institute for Occupational Safety and Health)
Substance is not listed.
Chemical safety assessment
A Chemical Safety Assessment has not been carried out.
Abbreviations and acronyms
IMDG: International Maritime Code for Dangerous Goods
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Flammable Solids 2: Flammable solids – Category 2
Self-heating substances and mixtures 2: Self-heating substances and mixtures – Category 2
Acute Toxicity - Oral 4: Acute toxicity – Category 4
Sensitization - Respiratory 1: Respiratory sensitisation – Category 1
Sensitization - Skin 1: Skin sensitisation – Category 1
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Flammable Solids 2: Flammable solids – Category 2
Self-heating substances and mixtures 2: Self-heating substances and mixtures – Category 2
Acute Toxicity - Oral 4: Acute toxicity – Category 4
Sensitization - Respiratory 1: Respiratory sensitisation – Category 1
Sensitization - Skin 1: Skin sensitisation – Category 1
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.