Chemical Safety Data Sheet MSDS / SDS
Preza-d3
Revision Date:2026-05-31Revision Number:1
Product identifier
- Product name: Preza-d3
- CBnumber: CB81873085
- CAS: 219533-68-3
- Synonyms: Heroin-d3
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P501 Dispose of contents/container to..…
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P320 Specific treatment is urgent (see … on this label).
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P330 Rinse mouth.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P284 Wear respiratory protection.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P271 Use only outdoors or in a well-ventilated area.
P270 Do not eat, drink or smoke when using this product.
P264 Wash skin thouroughly after handling.
P262 Do not get in eyes, on skin, or on clothing.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Hazard statements
No data available
Substance
- Product name: Preza-d3
- Synonyms: Heroin-d3
- CAS: 219533-68-3
- MF: C21H23NO5
- MW: 369.411
Description of first aid measures
General information
Immediately remove any clothing soiled by the product.
Remove breathing apparatus only after contaminated clothing have been completely removed.
In case of irregular breathing or respiratory arrest provide artificial respiration.
Remove breathing apparatus only after contaminated clothing have been completely removed.
In case of irregular breathing or respiratory arrest provide artificial respiration.
After inhalation
Supply fresh air or oxygen; call for doctor.
In case of unconsciousness place patient stably in side position for transportation.
In case of unconsciousness place patient stably in side position for transportation.
After skin contact
Immediately wash with water and soap and rinse thoroughly.
After eye contact
Rinse opened eye for several minutes under running water. If symptoms persist, consult a doctor.
After swallowing
Do not induce vomiting; immediately call for medical help.
Most important symptoms and effects, both acute and delayed
No further relevant information available.
Indicationof anyimmediate medical attention andspecial treatment needed
No furtherrele vant information available .
Extinguishing media
Suitable extinguishing agents
CO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
Special hazards arising from the substance or mixture
67-56-1During heating or in case of fire poisonous gases are produced.
Advice for firefighters
Protective equipment
Mouth respiratory protective device.
NFPA 704
4
0
0
| HEALTH | 4 | Very short exposure could cause death or major residual injury (e.g. hydrogen cyanide, phosgene, methyl isocyanate, hydrofluoric acid) | |
| FIRE | 0 | Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Mount respiratory protective device.
Wear protective equipment. Keep unprotected persons away.
Wear protective equipment. Keep unprotected persons away.
Environmental precautions
Dilute with plenty of water.
Do not allow to enter sewers/ surface or ground water.
Do not allow to enter sewers/ surface or ground water.
Methods and material for containment and cleaning up
Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).
Dispose contaminated material as waste according to section 13.
Ensure adequate ventilation.
Dispose contaminated material as waste according to section 13.
Ensure adequate ventilation.
Protective Action Criteria for Chemicals
PAC-1
75-05-8 Acetonitrile 13 ppm
PAC-2
75-05-8 Acetonitrile 50 ppm
PAC-3
75-05-8 Acetonitrile 150 ppm
Reference to other sections
See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
Precautions for safe handling
Ensure good ventilation/exhaustion at the workplace.
Open and handle receptacle with care.
Prevent formation of aerosols.
Open and handle receptacle with care.
Prevent formation of aerosols.
Information about protection against explosions and fires
Keep ignition sources away - Do not smoke.
Protect against electrostatic charges.
Keep respiratory protective device available.
Protect against electrostatic charges.
Keep respiratory protective device available.
Conditions for safe storage, including any incompatibilities
Storage
Store in accordance with information listed on the product insert.
Requirements to be met by storerooms and receptacles
Store in a cool location.
Information about storage in one common storage facility
Not required.
Further information about storage conditions
Keep receptacle tightly sealed.
Store in cool, dry conditions in well sealed receptacles.
Store in cool, dry conditions in well sealed receptacles.
Specific end use(s)
No further relevant information available.
Control parameters
Components with limit values that require monitoring at the workplace:
The following constituent is the only constituent of the product which has a PEL, TLV or other recommended exposure limit.
At this time, the remaining constituent has no known exposure limits.
The following constituent is the only constituent of the product which has a PEL, TLV or other recommended exposure limit.
At this time, the remaining constituent has no known exposure limits.
| 75-05-8 Acetonitrile | |
|---|---|
| PEL | Long-term value: 70 mg/m³, 40 ppm |
| REL | Long-term value: 34 mg/m³, 20 ppm |
| TLV | Long-term value: 20 ppm Skin, A4 |
Additional information
The lists that were valid during the creation were used as basis.
Exposure controls
Appropriate engineering controls
No further data; see section 7.
Personal protective equipment
General protective and hygienic measures
Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Store protective clothing separately.
Avoid contact with the eyes.
Avoid contact with the eyes and skin.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Store protective clothing separately.
Avoid contact with the eyes.
Avoid contact with the eyes and skin.
Breathing equipment
In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use respiratory protective device that is independent of circulating air.
Protection of hands
Protective gloves
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
Material of gloves
The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer. As the product is a preparation of several substances, the resistance of the glove material can not be calculated in advance and has therefore to be checked prior to the application.
Penetration time of glove material
The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed.
Eye protection
Tightly sealed goggles
Information on basic physicochemical properties
- Relative DensityNot determined.
- Density at 20 °C (68 °F)0.79 g/cm³ (6.59255 lbs/gal)
- Vapor Pressure at 50 °C (122 °F)330 hPa (247.5 mm Hg)
- Vapor Pressure at 20 °C (68 °F)98.64 hPa (74 mm Hg)
- Partition coefficient (n-octanol/water)Not determined.
- Water at 25 °C (77 °F)1000 g/l
- Dynamicat 20 °C (68 °F): 0.39 mPas
- KinematicNot determined.
- pHNot determined.
- Decomposition temperatureNot determined.
- Auto igniting525 °C (977 °F)
- Flash point5 °C (41 °F)
- Explosion limitsLower: 4.4 Vol %
Upper: 16 Vol % - FlammabilityHighly flammable.
- Boiling point/Boiling range81 °C (177.8 °F)
- Melting point/Melting range-46 °C (-50.8 °F)
- FormulationA 1 mg/ml solution in acetonitrile
- Odor ThresholdNot determined.
- Molecular Weight372.4 g/mol
- Structural FormulaC21H20D3NO5
- OdorAromatic
- ColorColorless
- Physical StateLiquid
- Evaporation RateNot determined.
- Solids content0.1 %
- VOC content0.00 % 0.0 g/l / 0.00 lb/gal
- Danger of explosionProduct is not explosive. However, formation of explosive air/vapor mixtures are possible.
- Ignition temperatureProduct is not selfigniting.
- FormLiquid
- Particle characteristicsNot applicable.
- Vapor DensityNot determined.
Reactivity
No further relevant information available.
Chemical stability
Thermal decomposition / conditions to be avoided
No decomposition if used according to specifications.
Possibility of hazardous reactions
No dangerous reactions known.
Conditions to avoid
No further relevant information available.
Incompatible materials
reducing agents, oxidizing agents
Hazardous decomposition products
carbon monoxide, carbon dioxide, hydrogen cyanide, nitrogen oxides
Information on toxicological effects
Acute toxicity
LD/LC50 values that are relevant for classification:
| Substance / Estimate | Route | Endpoint | Value |
|---|---|---|---|
| ATE (Acute Toxicity Estimate) | Oral | LD50 | 550 mg/kg (mouse) |
| ATE (Acute Toxicity Estimate) | Dermal | LD50 | 1,458 mg/kg (rabbit) |
| ATE (Acute Toxicity Estimate) | Inhalative | LC50/4 h | 9.02 mg/l |
| 75-05-8 Acetonitrile | Oral | LD50 | 617 mg/kg (mouse) (OECD Test Guideline 401) |
| 75-05-8 Acetonitrile | Dermal | LD50 | 1,500 mg/kg (rabbit) (Expert Judgement) Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2) |
| 75-05-8 Acetonitrile | Inhalative | LC50/4 h | 6.022 mg/l (mouse) (OECD Test Guideline 403) |
Primary irritant effect
on the skin
No irritant effect.
on the eye
Irritating effect.
Sensitization
No sensitizing effects known.
Additional toxicological information
The product shows the following dangers according to internally approved calculation methods for preparations
Toxic
Irritant
Toxic
Irritant
Interactive effects
No interactive effects between components are known.
Carcinogenic categories
IARC (International Agency for Research on Cancer)
None of the ingredients is listed.
NTP (National Toxicology Program)
None of the ingredients is listed.
OSHA-Ca (Occupational Safety & Health Administration)
None of the ingredients is listed.
Alternative sources for toxicological information
No non-standard sources for toxicological information where used.
Toxicity
Aquatic toxicity
No further relevant information available.
Persistence and degradability
No further relevant information available.
Bioaccumulative potential
No further relevant information available.
Mobility in soil
No further relevant information available.
Results of PBT and vPvB assessment
PBT
Not applicable.
vPvB
Not applicable.
PBT:
Not applicable.
vPvB:
Not applicable.
Other adverse effects
Additional ecological information
General notes
Water hazard class 2 (Self-assessment) hazardous for water
Do not allow product to reach ground water, water course or sewage system.
Danger to drinking water if even small quantities leak into the ground.
Do not allow product to reach ground water, water course or sewage system.
Danger to drinking water if even small quantities leak into the ground.
Waste treatment methods
Recommendation
Must not be disposed of together with household garbage. Do not allow product to reach sewage system.
Uncleaned packagings
Recommendation
Disposal must be made according to official regulations.
Recommended cleansing agent
Water, if necessary with cleansing agents.
UN-Number
DOT, IMDG, IATA UN1992
UN proper shipping name
DOT Flammable liquids, toxic, n.o.s. (Acetonitrile)
IMDG FLAMMABLE LIQUID, TOXIC, N.O.S.
(ACETONITRILE)
IATA Flammable liquid, toxic, n.o.s. (ACETONITRILE)
IMDG FLAMMABLE LIQUID, TOXIC, N.O.S.
(ACETONITRILE)
IATA Flammable liquid, toxic, n.o.s. (ACETONITRILE)
Transport hazard class(es)
DOTClass: 3 Flammable liquids
Label: 3, 6.1
IMDG
Label: 3, 6.1
Class: 3 Flammable liquids
Label: 3/6.1
IATA
Label: 3/6.1
Class: 3 Flammable liquids
Label: 3 (6.1)
Label: 3 (6.1)
Packing group
DOT, IMDG, IATA II
Environmental hazards
Not applicable.
Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code
Not applicable.
Transport/Additional information
DOT:
Quantity limitations
On passenger aircraft/rail: 1 L
On cargo aircraft only: 60 L
On cargo aircraft only: 60 L
IMDG:
Limited quantities (LQ)
1L
Excepted quantities (EQ)
Code: E2
Maximum net quantity per inner packaging: 30 ml
Maximum net quantity per outer packaging: 500 ml
Maximum net quantity per inner packaging: 30 ml
Maximum net quantity per outer packaging: 500 ml
IATA:
Remarks
When sold in quantities of less than or equal to 1 mL, or 1 g, with an Excepted Quantity Code of
E1, E2, E4, or E5, this item meets the De Minimis
Quantities exemption, per IATA 2.6.10.
Therefore packaging does not have to be labeled as
Dangerous Goods/Excepted Quantity.
E1, E2, E4, or E5, this item meets the De Minimis
Quantities exemption, per IATA 2.6.10.
Therefore packaging does not have to be labeled as
Dangerous Goods/Excepted Quantity.
Special precautions for user
Warning: Flammable liquids
Hazard identification number (Kemler code)
336
EMS Number
F-E, S-D
Stowage Category
B
Stowage Code
SW2 Clear of living quarters.
UN "Model Regulation"
UN 1992 FLAMMABLE LIQUID, TOXIC, N.O.S.
(ACETONITRILE), 3 (6.1), II
(ACETONITRILE), 3 (6.1), II
Safety, health and environmental regulations/legislation specific for the substance or mixture
No further relevant information available.
Sara
| Section 355 (extremely hazardous substances): | None of the ingredients is listed. |
| Section 313 (Specific toxic chemical listings): | 75-05-8 Acetonitrile |
| TSCA (Toxic Substances Control Act): | 75-05-8 Acetonitrile ACTIVE |
| Hazardous Air Pollutants 75-05-8 Acetonitrile | |
| Chemicals known to cause cancer: | None of the ingredients is listed. |
| Chemicals known to cause reproductive toxicity for females: | None of the ingredients is listed. |
| Chemicals known to cause reproductive toxicity for males: | None of the ingredients is listed. |
| Chemicals known to cause developmental toxicity: | None of the ingredients is listed. |
Carcinogenic categories
| EPA (Environmental Protection Agency): |
75-05-8
Acetonitrile CBD, D
TLV (Threshold Limit Value)
75-05-8
Acetonitrile A4
NIOSH-Ca (National Institute for Occupational Safety and Health)
None of the ingredients is listed.
Chemical safety assessment
A Chemical Safety Assessment has not been carried out.
Abbreviations and acronyms
IMDG: International Maritime Code for Dangerous Goods
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
ELINCS: European List of Notified Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
VOC: Volatile Organic Compounds (USA, EU)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Flammable liquids 2: Flammable liquids – Category 2
Acute toxicity - oral 3: Acute toxicity – Category 3
Eye irritation 2A: Serious eye damage/eye irritation – Category 2A
Specific target organ toxicity (single exposure) 1: Specific target organ toxicity (single exposure) – Category 1
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
ELINCS: European List of Notified Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
VOC: Volatile Organic Compounds (USA, EU)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Flammable liquids 2: Flammable liquids – Category 2
Acute toxicity - oral 3: Acute toxicity – Category 3
Eye irritation 2A: Serious eye damage/eye irritation – Category 2A
Specific target organ toxicity (single exposure) 1: Specific target organ toxicity (single exposure) – Category 1
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.