Rotenone

Acute toxicity - Category 3, Oral

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity – single exposure, Category 3

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

H301 Toxic if swalloed

H315 Causes skin irritation

H319 Causes serious eye irritation

H335 May cause respiratory irritation

H410 Very toxic to aquatic life with long lasting effects

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P273 Avoid release to the environment.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P391 Collect spillage. Hazardous to the aquatic environment

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313 IF eye irritation persists: Get medical advice/attention.

P501 Dispose of contents/container to..…

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P273 Avoid release to the environment.

P301+P316 IF SWALLOWED: Get emergency medical help immediately.

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P332+P317 If skin irritation occurs: Get medical help.

P362+P364 Take off contaminated clothing and wash it before reuse.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P319 Get medical help if you feel unwell.

P391 Collect spillage.

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest. Artificial respiration may be needed.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give a slurry of activated charcoal in water to drink. Rest. Refer for medical attention .

Exposure Routes: inhalation, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin, respiratory system; numb mucous membrane; nausea, vomiting, abdominal pain; muscle tremor, incoordination, clonic convulsions, stupor Target Organs: Eyes, skin, respiratory system, central nervous system (NIOSH, 2016)

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Rotenone and related compounds

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

Use water spray, powder, alcohol-resistant foam, carbon dioxide.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered air-tight containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Sweep spilled substance into covered air-tight containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Personal protection: P3 filter respirator for toxic particles. Do NOT let this chemical enter the environment.

1. Ventilate area of spill. 2. For small quantities, sweep onto paper or other suitable material, place in an appropriate container and burn in a safe place (such as a fume hood). Large quantities can be reclaimed; however, if this is not practical, dissolve in a flammable solvent (such as alc) and atomize in a suitable combustion chamber.

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from food and feedstuffs. Well closed.Store only in original containers, in a dry place inaccessible to children and pets. 7.4% Rotenone Wettable Powder

TLV: 5 mg/m3, as TWA; A4 (not classifiable as a human carcinogen).MAK: skin absorption (H)

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear safety goggles or eye protection in combination with breathing protection if powder.

Protective gloves.

Use local exhaust or breathing protection.

no data available

Decomposes on burning. This produces irritating fumes.

Decomp upon exposure to light and air. Colorless solutions in organic solvents oxidize upon exposure and become yellow, orange and then deep red and may deposit crystals of dehydrorotenone and rotenonone which are toxic to insects.

Flammable if preheated.ROTENONE is readily oxidized in the presence of alkalis. It is incompatible with oxidizers. (NTP, 1992).

no data available

Strong oxidizers, alkalis.

When heated to decomposition it emits acrid smoke and irritating fumes.

no data available

no data available

no data available

no data available

Cancer Classification: Group E Evidence of Non-carcinogenicity for Humans

no data available

The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. This may result in convulsions and respiratory depression.

Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the kidneys and liver.

Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly.

AEROBIC: In southern Italy, two types of soil samples spiked with rotenone, a silt clay loam and a loamy soil, underwent degradation experiments in dark conditions at 10-20 deg C. The results indicated that half-life values for rotenone were 8 days in the silt clay loam soil and 5 days in the loamy soil at 20 deg C. At 10 deg C however, the half-lives were 25 days for silt clay loam soil and 21 for the loamy soil(1). Rotenone is listed as one of the organic substances which may be degraded during aerobic and anaerobic sewage treatment if adequate acclimatization can be achieved; much depends on the concentration to be treated and possibly on the temperature during treatment(2).

A study showed that when yearling bluegills (Lepomis macrochirus) were exposed to 5.2 ug/L of rotenone for 30 days in a continuous flow system, bioconcentration factors for the head, viscera, and carcass were 165, 3,500, and 125, respectively(4). According to a classification scheme(3), bioconcentation factors of 100-100 are high and >1000 are very high(SRC).

The Koc of rotenone is estimated as approximately 3,200(SRC), using a measured log Kow of 4.10(1) and a regression-derived equation(2). According to a recommended classification scheme(3), this estimated Koc value suggests that rotenone is expected to have slight mobility in soil(SRC). The Kd values of rotenone were determined in 2 different soil types from Southern Italy. In the adsorption experiment Kd values were 0.56 and 2.73 L/kg for silt clay loam and loamy soil respectively, and the degradation rates were 0.102 and 0.074 d-1 for soils at 20 deg C(4).

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN2811 (For reference only, please check.)

IMDG: UN2811 (For reference only, please check.)

IATA: UN2811 (For reference only, please check.)

ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)

IMDG: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)

IATA: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

ADR/RID: I (For reference only, please check.)

IMDG: I (For reference only, please check.)

IATA: I (For reference only, please check.)

ADR/RID: Yes

IMDG: Yes

IATA: Yes

no data available

no data available

The substance is combustible but no flash point is available in literature.Carrier solvents used in commercial formulations may change physical and toxicological properties.Depending on the degree of exposure, periodic medical examination is suggested.