Trifluoroacetic acid
Product identifier
- Product name: Trifluoroacetic acid
- CBnumber: CB5127175
- CAS: 76-05-1
- EINECS Number: 200-929-3
- Synonyms: TFA,TRIFLUOROACETIC ACID
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Skin corrosion, Sub-category 1A
Acute toxicity - Category 4, Inhalation
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3
Label elements
Pictogram(s)
- Signal wordDanger
H290 May be corrosive to metals
H314 Causes severe skin burns and eye damage
H332 Harmful if inhaled
H412 Harmful to aquatic life with long lasting effects
P234 Keep only in original container.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P310 Immediately call a POISON CENTER or doctor/physician.
P390 Absorb spillage to prevent material damage.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P406 Store in corrosive resistant/… container with a resistant inner liner.
P501 Dispose of contents/container to..…
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316 Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P317 Get medical help.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards
no data available
Substance
- Product name: Trifluoroacetic acid
- Synonyms: TFA,TRIFLUOROACETIC ACID
- CAS: 76-05-1
- EC number: 200-929-3
- MF: C2HF3O2
- MW: 114.02
Description of first aid measures
If inhaledFresh air, rest. Half-upright position. Refer immediately for medical attention.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention.
Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.
Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention.
Most important symptoms and effects, both acute and delayed
no data available
Indication of any immediate medical attention and special treatment needed
no data available
Extinguishing media
Use dry chemical, carbon dioxide or alcohol-resistant foam.
Specific Hazards Arising from the Chemical
Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.
Advice for firefighters
In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep drums, etc., cool by spraying with water.
NFPA 704
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 0 | Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Personal protection: gas-tight chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable plastic containers. Absorb remaining liquid in sand or inert absorbent. Carefully collect remainder. Then store and dispose of according to local regulations.
Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
Precautions for safe handling
NO contact with bases, oxidizing agents or reducing agents. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from strong bases, metals, oxidants and food and feedstuffs. Keep in a well-ventilated room. Store in an area without drain or sewer access.
Control parameters
Occupational Exposure limit values| Component | Trifluoroacetic acid | |||
|---|---|---|---|---|
| CAS No. | 76-05-1 | |||
| Limit value - Eight hours | Limit value - Short term | |||
| ppm | mg/m3 | ppm | mg/m3 | |
| Latvia | ? | 2 | ? | ? |
| Remarks | ||||
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use ventilation, local exhaust or breathing protection.
no data available
Information on basic physicochemical properties
- Physical stateLiquid
- ColourColorless
- Odour
no data available
- Melting point/freezing point
-15.2 °C.
- Boiling point or initial boiling point and boiling range
71.78 °C. Atm. press.:1 013 hPa. Remarks:Extrapolated value.
- Flammability
no data available
- Lower and upper explosion limit/flammability limit
no data available
- Flash point
> 100 °C.
- Auto-ignition temperature
no data available
- Decomposition temperature
no data available
- pH1 (10g/l, H2O)
- Kinematic viscosity
dynamic viscosity (in mPa s) = 0.9 - 9. Temperature:20°C. Remarks:Shear rate from 20 to 100 s-1.;dynamic viscosity (in mPa s) = 1.8. Temperature:20°C. Remarks:Mean of n=10 x 3 measurements; SD=0.10; constant shear rate 2000 s-1.;dynamic viscosity (in mPa s) = 1.6. Temperature:40°C. Remarks:Mean of n=10 x 3 measurements; SD=0.01; constant shear rate 2000 s-1.
- SolubilityMiscible with ether, acetone, ethanol, benzene, hexane, and CCl<sub>4</sub>
- Partition coefficient n-octanol/water
log Pow = -2.1. Remarks:Thus, 1997.;log Pow = -0.2. Remarks:Calculated according to Rekker.;log Pow = 0.325. Remarks:ClogP for Windows V 1.0.0.
- Vapour pressure97.5 mm Hg ( 20 °C)
- Density and/or relative density1.480
- Relative vapour density1.480
- Particle characteristics
no data available
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
The vapour is heavier than air.Decomposes on contact with hot surfaces or flames. This produces toxic fumes. The substance is a medium strong acid. Reacts violently with strong bases, reducing agents and oxidants. This produces toxic and corrosive fumes including hydrogen fluoride. Attacks many metals. This produces flammable/explosive gas (hydrogen - see ICSC 0001). Attacks some forms of rubber.
Conditions to avoid
no data available
Incompatible materials
no data available
Hazardous decomposition products
no data available
Acute toxicity
- Oral: no data available
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of fumes may cause lung oedema. See Notes.
STOT-repeated exposure
no data available
Aspiration hazard
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C.
Toxicity
- Toxicity to fish: LC50 - Danio rerio (previous name: Brachydanio rerio) - > 1 200 mg/L - 96 h. Remarks:Na-TFA.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - > 1 200 mg/L - 48 h. Remarks:NaTFA.
- Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - 5.4 μmol/L - 72 h.
- Toxicity to microorganisms: EC50 - activated sludge, domestic - > 1 000 mg/L - 3 h. Remarks:NaTFA.
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: UN2699 (For reference only, please check.)
IMDG: UN2699 (For reference only, please check.)
IATA: UN2699 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: TRIFLUOROACETIC ACID (For reference only, please check.)
IMDG: TRIFLUOROACETIC ACID (For reference only, please check.)
IATA: TRIFLUOROACETIC ACID (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 8 (For reference only, please check.)
IMDG: 8 (For reference only, please check.)
IATA: 8 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.