Chemical Safety Data Sheet MSDS / SDS
Vitamin A palmitate
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: Vitamin A palmitate
- CBnumber: CB0406543
- CAS: 79-81-2
- EINECS Number: 201-228-5
- Synonyms: RETINYL PALMITATE;RETINOL PALMITATE
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P501 Dispose of contents/container to..…
P405 Store locked up.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P273 Avoid release to the environment.
P202 Do not handle until all safety precautions have been read and understood.
Hazard statements
H412 Harmful to aquatic life with long lasting effects
Substance
- Product name: Vitamin A palmitate
- Synonyms: Vitamin A palmitate,retinyl palmitate
- CAS: 79-81-2
- EC number: 201-228-5
- MF: C36H60O2
- MW: 524.86
4.1 Description of first-aid measures
General adviceShow this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.
In case of eye contact
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
4.4 Notes to physician
No data available
5.1 Extinguishing media
Suitable extinguishing mediaFoam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
Combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Prevent fire extinguishing water from contaminating surface water or the ground water system.
Prevent fire extinguishing water from contaminating surface water or the ground water system.
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.
Chemizorb®). Dispose of properly. Clean up affected area.
Chemizorb®). Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
Advice on safe handlingWork under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsTightly closed. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons.
Storage stabilityRecommended storage temperature
2 - 8 °C
Storage class
Storage class (TRGS 510): 6.1C: Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
8.1 Control parameters
Ingredients with workplace control parameters| ['Component', 'CAS-No.', 'Value', 'Control\nparameters', 'Basis'] | ['butyl\nhydroxytoluene', '128-37-0', 'TWA', '2 mg/m3', 'USA. ACGIH Threshold Limit\nValues (TLV)'] | |
|---|---|---|
| ['', 'Remarks', 'Not classifiable as a human carcinogen', None, None] | ['', '', 'TWA', '10 mg/m3', 'USA. NIOSH Recommended\nExposure Limits'] | ['', '', 'PEL', '10 mg/m3', 'California permissible exposure\nlimits for chemical\ncontaminants (Title 8, Article\n107)'] |
8.2 Exposure controls
Appropriate engineering controlsImmediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Skin protection
required
Body Protection
protective clothing
Respiratory protection
required when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Control of environmental exposure
Do not let product enter drains.
Information on basic physicochemical properties
- a) Physical stateliquid
- b) ColorLight Yellow to Yellow
- c) OdorNo data available
- d) Melting point/freezing pointNo data available
- e) Initial boiling point and boiling range546.51°C (rough estimate)
- f) Flammability (solid, gas)No data available
- g) Upper/lower flammability or explosive limitsNo data available
- h) Flash point194.00 °C
- i) Autoignition temperatureNo data available
- j) Decomposition temperatureNo data available
- k) pHNo data available
- l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: No data available - m) Water solubilitySoluble in chloroform, ether, and vegetable oils. Insoluble in water.
- n) Partition coefficient n-octanol/waterNo data available
- o) Vapor pressureNo data available
- p) Density0.9668 (rough estimate)
- Relative density0.9668 (rough estimate)
- q) Relative vapor densityNo data available
- r) Particle characteristicsNo data available
- s) Explosive propertiesNot classified as explosive.
- t) Oxidizing propertiesnone
- SolubilityChloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)
9.2 Other safety information
No data available
10.1 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.2 Possibility of hazardous reactions
No data available
10.3 Conditions to avoid
Strong heating.
10.4 Incompatible materials
No data available
10.5 Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Mixture Acute toxicityOral: No data available
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Inhalation: No data available
Dermal: No data available
Classified based on available data. For more details, see section 2
Serious eye damage/eye irritation
Classified based on available data. For more details, see section 2
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
May harm the unborn child.
May impair fertility.
Specific target organ toxicity - single exposure
May impair fertility.
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
Components Vitamin A palmitate
This substance should be handled with particular care.
Acute toxicity
LD50 Oral - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 401)
Inhalation: No data available
Dermal: No data available
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Serious eye damage/eye irritation
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Eyes - Rabbit
Result: No eye irritation - 72 h (OECD Test Guideline 405)
Respiratory or skin sensitization
Result: No eye irritation - 72 h (OECD Test Guideline 405)
Maximization Test - Guinea pig
Result: Does not cause skin sensitization.
(OECD Test Guideline 406)
Germ cell mutagenicity
Result: Does not cause skin sensitization.
(OECD Test Guideline 406)
Classified based on available data. For more details, see section 2
Test Type: Ames test
Test system: S. typhimurium
Result: negative
Method: OECD Test Guideline 474
Species: Mouse - male
Result: negative
Method: OECD Test Guideline 474
Species: Mouse - male
Result: negative
Carcinogenicity
Test Type: Ames test
Test system: S. typhimurium
Result: negative
Method: OECD Test Guideline 474
Species: Mouse - male
Result: negative
Method: OECD Test Guideline 474
Species: Mouse - male
Result: negative
Classified based on available data. For more details, see section 2
Reproductive toxicity
May damage the unborn child.
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
butyl hydroxytoluene (BHT) Acute toxicity
LD50 Oral - Rat - male and female - > 6,000 mg/kg (OECD Test Guideline 401)
Inhalation: No data available
LD50 Dermal - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 402)
Skin corrosion/irritation
Inhalation: No data available
LD50 Dermal - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 402)
Skin - Rabbit
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Serious eye damage/eye irritation
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Eyes - Rabbit
Result: No eye irritation (OECD Test Guideline 405)
Respiratory or skin sensitization
Result: No eye irritation (OECD Test Guideline 405)
Patch test: - In vitro study
Result: negative
Remarks: (ECHA)
Germ cell mutagenicity
Result: negative
Remarks: (ECHA)
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Remarks: (ECHA)
Test Type: In vitro mammalian cell gene mutation test
Test system: rat hepatocytes
Result: negative
Remarks: (ECHA)
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Result: negative
Remarks: (ECHA)
Species: Mouse - male and female - Bone marrow
Result: negative
Remarks: (ECHA)
Species: Rat - male - Bone marrow
Result: negative
Remarks: (ECHA)
Carcinogenicity
Test system: Salmonella typhimurium
Result: negative
Remarks: (ECHA)
Test Type: In vitro mammalian cell gene mutation test
Test system: rat hepatocytes
Result: negative
Remarks: (ECHA)
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Result: negative
Remarks: (ECHA)
Species: Mouse - male and female - Bone marrow
Result: negative
Remarks: (ECHA)
Species: Rat - male - Bone marrow
Result: negative
Remarks: (ECHA)
This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC, ACGIH, NTP, or EPA classification.
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
12.1 Toxicity
MixtureNo data available
12.2 Persistence and degradability
No data available
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
No data available
Components Vitamin A palmitate
Toxicity to fish static test LC50 - Leuciscus idus (Golden orfe) - > 10,000 mg/l - 96 h (DIN 38412)
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - 35.34 mg/l - and other aquatic 48 h invertebrates (OECD Test Guideline 202)
Toxicity to algae static test ErC50 - Desmodesmus subspicatus (green algae) - 152.94 mg/l - 72 h
Remarks: (ECHA)
butyl hydroxytoluene (BHT)
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - 35.34 mg/l - and other aquatic 48 h invertebrates (OECD Test Guideline 202)
Toxicity to algae static test ErC50 - Desmodesmus subspicatus (green algae) - 152.94 mg/l - 72 h
Remarks: (ECHA)
Toxicity to fish semi-static test LC50 - Danio rerio (zebra fish) - > 0.57 mg/l - 96 h (Directive 67/548/EEC, Annex V, C.1.)
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - 0.48 mg/l - 48 and other aquatic h invertebrates (OECD Test Guideline 202)
Toxicity to algae static test ErC50 - Desmodesmus subspicatus (green algae) - > 0.4 mg/l - 72 h (Regulation (EC) No. 440/2008, Annex, C.3)
Toxicity to bacteria static test EC50 - activated sludge - > 10,000 mg/l - 3 h (OECD Test Guideline 209)
Toxicity to NOEC - Oryzias latipes - 0.053 mg/l - 30 d fish(Chronic toxicity) (OECD Test Guideline 210)
Toxicity to daphnia EC50 - Daphnia magna (Water flea) - 0.096 mg/l - 21 d and other aquatic (OECD Test Guideline 211) invertebrates(Chronic toxicity)
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - 0.48 mg/l - 48 and other aquatic h invertebrates (OECD Test Guideline 202)
Toxicity to algae static test ErC50 - Desmodesmus subspicatus (green algae) - > 0.4 mg/l - 72 h (Regulation (EC) No. 440/2008, Annex, C.3)
Toxicity to bacteria static test EC50 - activated sludge - > 10,000 mg/l - 3 h (OECD Test Guideline 209)
Toxicity to NOEC - Oryzias latipes - 0.053 mg/l - 30 d fish(Chronic toxicity) (OECD Test Guideline 210)
Toxicity to daphnia EC50 - Daphnia magna (Water flea) - 0.096 mg/l - 21 d and other aquatic (OECD Test Guideline 211) invertebrates(Chronic toxicity)
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Offer surplus and non-recyclable solutions to a licensed disposal company.
14.1 UN number
ADR/RID: -
IMDG: -
IATA-DGR: -
IMDG: -
IATA-DGR: -
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA-DGR: Not dangerous goods
IMDG: Not dangerous goods
IATA-DGR: Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID: -
IMDG: -
IATA-DGR: -
IMDG: -
IATA-DGR: -
14.4 Packaging group
ADR/RID: -
IMDG: -
IATA-DGR: -
IMDG: -
IATA-DGR: -
14.5 Environmental hazards
ADR/RID: no
IMDG Marine pollutant: no
IATA-DGR: no
IMDG Marine pollutant: no
IATA-DGR: no
14.6 Special precautions for user
14.7 Incompatible materials
Further information: Not classified as dangerous in the meaning of transport regulations.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulatory information
Law on the Prevention and Control of Occupational Diseases
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Law on the Prevention and Control of Occupational Diseases
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.