Cucurbitacin E
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- ₹24745.95 - ₹99395.15
- Product name: Cucurbitacin E
- CAS: 18444-66-1
- MF: C32H44O8
- MW: 556.69
- EINECS:242-325-2
- MDL Number:MFCD00135936
- Synonyms:A-ELATERIN;ALPHA-ELATERIN;CUCURBITACIN E;CUCURBITACIN E(SH);19-nor-9-beta,10-alpha-lanosta-1,5,23-triene-3,11,22-trione,2,16-alpha,20,25-t ;25-acetate ;alpha-elaterine ;cucurbitacine-e
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0577
- Product descriptionCucurbitacin E ≥95% (HPLC)
- Packaging5MG
- Price₹24745.95
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0577
- Product descriptionCucurbitacin E ≥95% (HPLC)
- Packaging25MG
- Price₹99395.15
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0577 | Cucurbitacin E ≥95% (HPLC) | 5MG | ₹24745.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0577 | Cucurbitacin E ≥95% (HPLC) | 25MG | ₹99395.15 | 2022-06-14 | Buy |
Properties
Melting point :228-234°C
alpha :D -59° (c = 0.7 in chloroform)
Boiling point :545.56°C (rough estimate)
Density :1.1059 (rough estimate)
refractive index :1.4900 (estimate)
storage temp. :-20°C
solubility :DMSO: soluble15mg/mL, clear
form :powder
pka :8.51±0.70(Predicted)
color :white to beige
optical activity :[α]/D -60 to -75°, c = 0.7 (CDCl3)
InChIKey :NDYMQXYDSVBNLL-MUYMLXPFSA-N
SMILES :[C@@]12(C)C[C@@H](O)[C@]([H])([C@](O)(C)C(=O)/C=C/C(C)(C)OC(=O)C)[C@@]1(C)CC(=O)[C@@]1(C)[C@]3([H])C=C(C(=O)C(C)(C)C3=CC[C@@]21[H])O |&1:0,3,5,7,21,26,28,40,r|
LogP :3.150 (est)
alpha :D -59° (c = 0.7 in chloroform)
Boiling point :545.56°C (rough estimate)
Density :1.1059 (rough estimate)
refractive index :1.4900 (estimate)
storage temp. :-20°C
solubility :DMSO: soluble15mg/mL, clear
form :powder
pka :8.51±0.70(Predicted)
color :white to beige
optical activity :[α]/D -60 to -75°, c = 0.7 (CDCl3)
InChIKey :NDYMQXYDSVBNLL-MUYMLXPFSA-N
SMILES :[C@@]12(C)C[C@@H](O)[C@]([H])([C@](O)(C)C(=O)/C=C/C(C)(C)OC(=O)C)[C@@]1(C)CC(=O)[C@@]1(C)[C@]3([H])C=C(C(=O)C(C)(C)C3=CC[C@@]21[H])O |&1:0,3,5,7,21,26,28,40,r|
LogP :3.150 (est)
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Cucurbitacin E is a plant-derived triterpene that has diverse biological activities. At a concentration of 10 pM, it reduces MPP+-induced death of neuronal PC12 cells through inhibition of autophagy in vitro. Cucurbitacin E inhibits growth of T24 bladder, MDA-MB-468 and MCF-7 breast, PC3 prostate, and colorectal cancer cell lines (IC50s = 50-1,000 nM) through induction of G2/M arrest and apoptosis. It increases bilirubin binding to human serum albumin (HSA) in human plasma in a dose-dependent manner. Cucurbitacin E also inhibits depolymerization of actin filaments isolated from rabbit skeletal muscle actin and in HeLa cells.Related product price
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