Linoleoylethanolamide
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- ₹30526.5
- Product name: Linoleoylethanolamide
- CAS: 68171-52-8
- MF: C20H37NO2
- MW: 323.51
- EINECS:269-029-6
- MDL Number:MFCD00674434
- Synonyms:N-(2-HYDROXYETHYL)-9Z, 12Z-OCTADECADIENAMIDE;ODNHETOH;n-(2-hydroxyethyl)-,(z,z)-12-octadecadienamide ;(9Z,12Z)-N-(2-hydroxyethyl)octadeca-9,12-dien-1-amide ;9,12-Octadecadienamide, N-(2-hydroxyethyl)-, (9Z,12Z)-;Linoleic ethanolamine;(9Z,12Z)-N-(2-Hydroxyethyl)-9,12-octadecadienamide;(9Z,12Z)-N-(2-Hydroxyethyl)-9,12-octadecadienoic acidamide
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Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 10MG
- ManufacturerSigma-Aldrich(India)
- Product numberL1164
- Product descriptionLinoleyl ethanolamide ≥98%, ethanol solution
- Packaging10MG
- Price₹30526.5
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | L1164 | Linoleyl ethanolamide ≥98%, ethanol solution | 10MG | ₹30526.5 | 2022-06-14 | Buy |
Properties
Melting point :38-40 °C
Boiling point :499.1±38.0 °C(Predicted)
Density :0.926±0.06 g/cm3(Predicted)
Flash point :14 °C - closed cup
storage temp. :-20°C
solubility :DMF:25.0(Max Conc. mg/mL);77.27(Max Conc. mM)
DMSO:25.0(Max Conc. mg/mL);77.27(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);154.55(Max Conc. mM) pka :14.49±0.10(Predicted)
form :ethanol solution
color :Light yellow to light brown
Stability :Light Sensitive, Temperature Sensitive
Cosmetics Ingredients Functions :SURFACTANT - FOAM BOOSTING
HAIR CONDITIONING
VISCOSITY CONTROLLING
ANTISTATIC InChI :1S/C20H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h6-7,9-10,22H,2-5,8,11-19H2,1H3,(H,21,23)/b7-6-,10-9-
InChIKey :KQXDGUVSAAQARU-HZJYTTRNSA-N
SMILES :CCCCC\C=C/C\C=C/CCCCCCCC(=O)NCCO
LogP :6.003 (est)
EPA Substance Registry System :9,12-Octadecadienamide, N-(2-hydroxyethyl)-, (9Z,12Z)- (68171-52-8)
Boiling point :499.1±38.0 °C(Predicted)
Density :0.926±0.06 g/cm3(Predicted)
Flash point :14 °C - closed cup
storage temp. :-20°C
solubility :DMF:25.0(Max Conc. mg/mL);77.27(Max Conc. mM)
DMSO:25.0(Max Conc. mg/mL);77.27(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);154.55(Max Conc. mM) pka :14.49±0.10(Predicted)
form :ethanol solution
color :Light yellow to light brown
Stability :Light Sensitive, Temperature Sensitive
Cosmetics Ingredients Functions :SURFACTANT - FOAM BOOSTING
HAIR CONDITIONING
VISCOSITY CONTROLLING
ANTISTATIC InChI :1S/C20H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h6-7,9-10,22H,2-5,8,11-19H2,1H3,(H,21,23)/b7-6-,10-9-
InChIKey :KQXDGUVSAAQARU-HZJYTTRNSA-N
SMILES :CCCCC\C=C/C\C=C/CCCCCCCC(=O)NCCO
LogP :6.003 (est)
EPA Substance Registry System :9,12-Octadecadienamide, N-(2-hydroxyethyl)-, (9Z,12Z)- (68171-52-8)
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
Linoleoyl ethanolamide is an endocannabinoid detected in porcine brain and murine peritoneal macrophages which contains linoleate in place of the arachidonate moiety of arachidonyl ethanolamide (AEA). It has weak affinity for the cannabinoid 1 (CB1) and CB2 receptors, exhibiting Ki values of 10 μM and 25 μM, respectively. However, it is only approximately 4-fold less potent than AEA at causing catalepsy in mice (ED50 of 26.5 mg/kg). In addition, linoleoyl ethanolamide increases ERK phosphorylation and AP-1-dependent transcription approximately 1.5 fold at 15 μM in a CB-receptor-independent manner. However, cellular toxicity is readily apparent at concentrations of 10-20 μM. Linoleoyl ethanolamide inhibits human fatty acid amide hydrolase-dependent hydrolysis of AEA with a Ki value of 9.0 μM, but also is hydrolyzed effectively by the enzyme.Related product price
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