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ChemicalBook >> CAS DataBase List >> Trifluoperazine dihydrochloride

Trifluoperazine dihydrochloride

Trifluoperazine dihydrochloride price.
  • $28 - $875
  • Product name: Trifluoperazine dihydrochloride
  • CAS: 440-17-5
  • MF: C21H26Cl2F3N3S
  • MW: 480.42
  • EINECS:207-123-0
  • MDL Number:MFCD00012656
  • Synonyms:LABOTEST-BB LT00452002;10-[3-(4-METHYL-1-PIPERAZINYL)PROPYL]-2-TRIFLUOROMETHYL-PHENOTHIAZINE DIHYDROCHLORIDE;10-[3-(4-METHYLPIPERAZIN-1-YL)PROPYL]-2-(TRIFLUOROMETHYL)-10H-PHENOTHIAZINE DIHYDROCHLORIDE;TRIFLUOPERAZINE 2HCL;TRIFLUOPERAZINE DIHYDROCHLORIDE;TRIFLUOPERAZINE HCL;TRIFLUOPERAZINE HYDROCHLORIDE;STELAZINE
27 prices
Selected condition:
Brand
  • AHH
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • Chem-Impex
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • TRC
  • Usbiological
Package
  • t2000000
  • 1unit
  • 10mg
  • 50mg
  • 100mg
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  • 250mg
  • 500mg
  • 1mL
  • 1g
  • 10g
  • 500g
  • 10mM(in 1mL DMSO)
  • 5g
  • 25g
  • ManufacturerAHH
  • Product numberMT-59871
  • Product descriptionTrifluoperazine dihydrochloride 99%
  • Packaging500g
  • Price$580
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ99715
  • Product descriptionTrifluroperazinedihydrochloride
  • Packaging10g
  • Price$88
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ10697
  • Product descriptionTrifluroperazinedihydrochloride
  • Packaging1g
  • Price$189
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0004238
  • Product descriptionSTELAZINE 95.00%
  • Packaging1G
  • Price$148.05
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1397
  • Product descriptionTrifluoperazine2HCl
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1397
  • Product descriptionTrifluoperazine2HCl
  • Packaging100mg
  • Price$37
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1397
  • Product descriptionTrifluoperazine2HCl
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1397
  • Product descriptionTrifluoperazine2HCl
  • Packaging500mg
  • Price$67
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15068
  • Product descriptionTrifluoperazine (hydrochloride) ≥98%
  • Packaging1g
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15068
  • Product descriptionTrifluoperazine (hydrochloride) ≥98%
  • Packaging5g
  • Price$70
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15068
  • Product descriptionTrifluoperazine (hydrochloride) ≥98%
  • Packaging10g
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15068
  • Product descriptionTrifluoperazine (hydrochloride) ≥98%
  • Packaging25g
  • Price$190
  • Updated2024-03-01
  • Buy
  • ManufacturerChem-Impex
  • Product number38298
  • Product descriptionTrifluoperazinedihydrochloride,≥98%(HPLC) ≥98%(HPLC)
  • Packaging25G
  • Price$354.1
  • Updated2021-12-16
  • Buy
  • ManufacturerChem-Impex
  • Product number38298
  • Product descriptionTrifluoperazinedihydrochloride,98%(HPLC) 98%(HPLC)
  • Packaging5G
  • Price$88.48
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001893
  • Product descriptionTrifluoperazine dihydrochloride 98+%
  • Packaging250mg
  • Price$117
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC9157
  • Product descriptionTrifluoperazine dihydrochloride >98%
  • Packaging1g
  • Price$300
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH MT-59871 Trifluoperazine dihydrochloride 99% 500g $580 2021-12-16 Buy
AK Scientific J99715 Trifluroperazinedihydrochloride 10g $88 2021-12-16 Buy
AK Scientific J10697 Trifluroperazinedihydrochloride 1g $189 2021-12-16 Buy
American Custom Chemicals Corporation API0004238 STELAZINE 95.00% 1G $148.05 2021-12-16 Buy
ApexBio Technology B1397 Trifluoperazine2HCl 1unit $28 2021-12-16 Buy
ApexBio Technology B1397 Trifluoperazine2HCl 100mg $37 2021-12-16 Buy
ApexBio Technology B1397 Trifluoperazine2HCl 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology B1397 Trifluoperazine2HCl 500mg $67 2021-12-16 Buy
Cayman Chemical 15068 Trifluoperazine (hydrochloride) ≥98% 1g $32 2024-03-01 Buy
Cayman Chemical 15068 Trifluoperazine (hydrochloride) ≥98% 5g $70 2024-03-01 Buy
Cayman Chemical 15068 Trifluoperazine (hydrochloride) ≥98% 10g $109 2024-03-01 Buy
Cayman Chemical 15068 Trifluoperazine (hydrochloride) ≥98% 25g $190 2024-03-01 Buy
Chem-Impex 38298 Trifluoperazinedihydrochloride,≥98%(HPLC) ≥98%(HPLC) 25G $354.1 2021-12-16 Buy
Chem-Impex 38298 Trifluoperazinedihydrochloride,98%(HPLC) 98%(HPLC) 5G $88.48 2021-12-16 Buy
Crysdot CD31001893 Trifluoperazine dihydrochloride 98+% 250mg $117 2021-12-16 Buy
DC Chemicals DC9157 Trifluoperazine dihydrochloride >98% 1g $300 2021-12-16 Buy

Properties

Melting point :243 °C (dec.)(lit.)
Flash point :9℃
storage temp. :-20°C
solubility :ethanol: soluble5mg/mL
pka :pK1 3.9, pK2 8.1(at 25℃)
form :powder
color :white to off-white
λmax :312nm(MeOH)(lit.)
Merck :14,9680
BRN :3820024
Stability :Hygroscopic
CAS DataBase Reference :440-17-5(CAS DataBase Reference)
EPA Substance Registry System :10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, dihydrochloride (440-17-5)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P201 Obtain special instructions before use.
P273 Avoid release to the environment.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents. It antagonizes adrenergic receptors, with selectivity for α1 over the α2 subtypes (Kis = 24, 653, 163, and 391 nM for α1A, α2A, α2B, and α2C, respectively). TFP binds with much higher affinity to the dopamine D2-like receptor (Kd = 0.96 nM) compared to the dopamine D4-like and the serotonin 5-HT2A receptors (Kds = 44 and 135 nM, respectively). Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ). TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.

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