ACTINONIN
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- $76 - $4350
- Product name: ACTINONIN
- CAS: 13434-13-4
- MF: C19H35N3O5
- MW: 385.5
- EINECS:
- MDL Number:MFCD00058569
- Synonyms:(-)-ACTINONIN;3-[[1-[[2-(HYDROXYMETHYL)-1-PYRROLIDINYL]CARBONYL]-2-METHYL-PROPYL]CARBAMOYL]OCTANOHYDROXAMIC ACID;3-[[1-[[2-(HYDROXYMETHYL)-1-PYRROLIDINYL]-CARBONYL]-2-METHYLPROPYL]-CARBAMOYL]-OCTONOHYDROXAMIC ACID;N4-HYDROXY-N1-[(1S)-1[[(2S)-2-(HYDROXYMETHYL)-1-PYRROLDINYL]CARBONYL]-2-METHYLPROPYL]-2-PENTYL-,(2R)-(9CI);hylpropyl)carbamoyl)- ;octanohydroxamicacid,3-((1-((2-(hydroxymethyl)-1-pyrrolidinyl)carbonyl)-2-met ;N'-Hydroxy-N-[1-[[2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentylbutanediamide;(2R)-2-[2-(hydroxyamino)-2-keto-ethyl]-N-[(1S)-2-methyl-1-[(2S)-2-methylolpyrrolidine-1-carbonyl]propyl]enanthamide
28 prices
Selected condition：
Brand
- Adipogen Life Sciences
- Ambeed
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- Medical Isotopes, Inc.
- Sigma-Aldrich
Package
- 1mg
- 2mg
- 5mg
- 1mlx10mM(inDMSO)
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0161-M005
- Product descriptionActinonin >97.0%(HPLC)
- Packaging5mg
- Price$98
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA236595
- Product descriptionActinonin 95%
- Packaging1mg
- Price$76
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC3331
- Product descriptionActinonin
- Packaging5mg
- Price$121
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC3331
- Product descriptionActinonin
- Packaging25mg
- Price$516
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb1089764
- Product descriptionActinonin >98%
- Packaging100mg
- Price$1200
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb1089764
- Product descriptionActinonin >98%
- Packaging250mg
- Price$2190
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb1089764
- Product descriptionActinonin >98%
- Packaging1g
- Price$4350
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb3132249
- Product descriptionActinonin 99.74%(Mayvarybetweenbatches)
- Packaging10mg
- Price$190
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb546076
- Product descriptionActinonin >98%
- Packaging5mg
- Price$290.7
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb3132249
- Product descriptionActinonin 99.74%(Mayvarybetweenbatches)
- Packaging1mg
- Price$80
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb3132249
- Product descriptionActinonin 99.74%(Mayvarybetweenbatches)
- Packaging2mg
- Price$90
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb546076
- Product descriptionActinonin >98%
- Packaging1mg
- Price$127.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb3132249
- Product descriptionActinonin 99.74%(Mayvarybetweenbatches)
- Packaging1mlx10mM(inDMSO)
- Price$130
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb3132249
- Product descriptionActinonin 99.74%(Mayvarybetweenbatches)
- Packaging5mg
- Price$130
- Updated2026-05-06
- Buy
- ManufacturerCayman Chemical
- Product number16605
- Product descriptionActinonin ≥95%
- Packaging5mg
- Price$125
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number16605
- Product descriptionActinonin ≥98%
- Packaging5mg
- Price$113
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CN2-0161-M005 | Actinonin >97.0%(HPLC) | 5mg | $98 | 2021-12-16 | Buy |
| Ambeed | A236595 | Actinonin 95% | 1mg | $76 | 2021-12-16 | Buy |
| ApexBio Technology | C3331 | Actinonin | 5mg | $121 | 2021-12-16 | Buy |
| ApexBio Technology | C3331 | Actinonin | 25mg | $516 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb1089764 | Actinonin >98% | 100mg | $1200 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1089764 | Actinonin >98% | 250mg | $2190 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1089764 | Actinonin >98% | 1g | $4350 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb3132249 | Actinonin 99.74%(Mayvarybetweenbatches) | 10mg | $190 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb546076 | Actinonin >98% | 5mg | $290.7 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb3132249 | Actinonin 99.74%(Mayvarybetweenbatches) | 1mg | $80 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb3132249 | Actinonin 99.74%(Mayvarybetweenbatches) | 2mg | $90 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb546076 | Actinonin >98% | 1mg | $127.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb3132249 | Actinonin 99.74%(Mayvarybetweenbatches) | 1mlx10mM(inDMSO) | $130 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb3132249 | Actinonin 99.74%(Mayvarybetweenbatches) | 5mg | $130 | 2026-05-06 | Buy |
| Cayman Chemical | 16605 | Actinonin ≥95% | 5mg | $125 | 2026-04-30 | Buy |
| Cayman Chemical | 16605 | Actinonin ≥98% | 5mg | $113 | 2024-03-01 | Buy |
Properties
Melting point :137-139°C
Density :1.139±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
pka :9.19±0.20(Predicted)
form :White to off-white powder.
color :White
biological source :synthetic (organic)
BRN :1555250
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI :1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)
InChIKey :XJLATMLVMSFZBN-UHFFFAOYSA-N
SMILES :CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO
CAS DataBase Reference :13434-13-4(CAS DataBase Reference)
Density :1.139±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
pka :9.19±0.20(Predicted)
form :White to off-white powder.
color :White
biological source :synthetic (organic)
BRN :1555250
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI :1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)
InChIKey :XJLATMLVMSFZBN-UHFFFAOYSA-N
SMILES :CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO
CAS DataBase Reference :13434-13-4(CAS DataBase Reference)
Safety Information
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Description
Actinonin is a peptidomimetic antibiotic produced by Actinomyces that inhibits aminopeptidases. It inhibits the following matrix metalloproteinases (MMPs): MMP-1 (Ki = 300 nM), MMP-2 (IC50 = ~90 nM), MMP-3 (Ki = 1,700 nM), MMP-7 (IC50 = ~3,500 nM), MMP-8 (Ki = 130 nM), MMP-9 (Ki = 330 nM), MMP-10 (IC50 = ~500 nM), MMP-12 (IC50 = ~350 nM), and MMP-13 (IC50 = ~100 nM), but not MMP-14 (IC50 > 1 mM). Actinonin acts as an herbicide by targeting plastid peptide deformylase, an enzyme required for N-terminal processing of plastid-encoded proteins. Actinonin has also been identified as an effective inhibitor of human meprin α (Ki = 20 nM), a zinc endopeptidase that cleaves matrix proteins. More recently actinonin has been shown to inhibit tumor cell invasion and matrix degradation and to induce apoptosis in animal models by targeting human mitochondrial peptide deformylase.Related product price
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