Axitinib-13C-d3
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- $605 - $1151
- Product name: Axitinib-13C-d3
- CAS: 1261432-00-1
- MF:
- MW: 0
- EINECS:
- MDL Number:MFCD32858131
- Synonyms:Axitinib-13C-d3;[13C,2H3]-Axitinib;(E)-N-(methyl-13C-d3)-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide
2 prices
Selected condition：
Brand
- Cayman Chemical
Package
- 500μg
- 1mg
- ManufacturerCayman Chemical
- Product number26676
- Product descriptionAxitinib-13C-d3
- Packaging500μg
- Price$605
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number26676
- Product descriptionAxitinib-13C-d3
- Packaging1mg
- Price$1151
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Cayman Chemical | 26676 | Axitinib-13C-d3 | 500μg | $605 | 2024-03-01 | Buy |
| Cayman Chemical | 26676 | Axitinib-13C-d3 | 1mg | $1151 | 2024-03-01 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMSO: soluble
form :A solid
solubility :DMSO: soluble
form :A solid
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||||
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Description
Axitinib-13C-d3 is intended for use as an internal standard for the quantification of axitinib by GC- or LC-MS. Axitinib is a VEGFR inhibitor (IC50s = 1.2, 0.25, and 0.29 nM for VEGFR1, -2, and -3, respectively). It also inhibits c-Kit and PDGFRβ (IC50s = 1.7 and 1.6 nM, respectively). It inhibits VEGF-induced migration of and tube formation by human umbilical vein endothelial cells (HUVECs). Axitinib (1-100 mg/kg) reduces microvessel density, a marker of angiogenesis, and tumor growth in MV522 colon carcinoma, A375 melanoma, SN12C-GFP renal carcinoma, and U87 glioma mouse xenograft models in a dose-dependent manner. Formulations containing axitinib have been used in the treatment of renal cell carcinoma.Related product price
- BenzaMide, 2-[(3-iodo-1H-indazol-6-yl)thio]-N-Methyl-
$496.33-1647 - Axitinib Impurity a
$62-345 - 2-(1H-indazol-6-ylthio)-N-Methyl- BenzaMide
$617-653
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