DO264
|
- $42 - $2400
- Product name: DO264
- CAS: 2301866-59-9
- MF: C23H20Cl2F3N5O2S
- MW: 558.4
- EINECS:604-604-1
- MDL Number:MFCD31812603
- Synonyms:N-[1-[3-Chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]-2-pyridinyl]-4-piperidinyl]-N'-3-pyridinylthiourea;Thiourea, N-[1-[3-chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]-2-pyridinyl]-4-piperidinyl]-N'-3-pyridinyl-;DO264;DO-264;DO 264;DO264 (DO-264;DO264;1-(1-(3-Chloro-4-(2-chloro-4-(trifluoromethoxy)phenoxy)pyridin-2-yl)piperidin-4-yl)-3-(pyridin-3-yl)thiourea
30 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Arctom
- Axon Medchem
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
Package
- 50mg
- 250mg
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO
- 1g
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 5mg
- 10mg
- 25MG
- 100MG
- Manufactureraablocks
- Product numberAA01FS11
- Product descriptionDO-264 98%
- Packaging1mg
- Price$42
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01FS11
- Product descriptionDO-264 98%
- Packaging5mg
- Price$98
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01FS11
- Product descriptionDO-264 98%
- Packaging10mg
- Price$157
- Updated2026-05-30
- Buy
- ManufacturerACHEMBLOCK
- Product numberT99517
- Product descriptionDO-264 98%
- Packaging5MG
- Price$145
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberT99517
- Product descriptionDO-264 98%
- Packaging25MG
- Price$525
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberT99517
- Product descriptionDO-264 98%
- Packaging100MG
- Price$1260
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number8011EL
- Product descriptionCID134813646
- Packaging1mg
- Price$179
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberHY-114157
- Product descriptionDO-264 99.96%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$167
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-114157
- Product descriptionDO-264 99.96%
- Packaging10mM*1mLinDMSO(Solution)
- Price$175
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-114157
- Product descriptionDO-264 99.96%
- Packaging10mg
- Price$238
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-114157
- Product descriptionDO-264 99.96%
- Packaging5mg
- Price$143
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-114157
- Product descriptionDO-264 99.96%
- Packaging100mg
- Price$1254
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-114157
- Product descriptionDO-264 99.96%
- Packaging25mg
- Price$494
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-114157
- Product descriptionDO-264 99.96%
- Packaging50mg
- Price$789
- Updated2026-05-26
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2982
- Product descriptionDO264
- Packaging25mg
- Price$511.5
- Updated2026-05-19
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2982
- Product descriptionDO264
- Packaging5mg
- Price$137.5
- Updated2026-05-19
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA01FS11 | DO-264 98% | 1mg | $42 | 2026-05-30 | Buy |
| aablocks | AA01FS11 | DO-264 98% | 5mg | $98 | 2026-05-30 | Buy |
| aablocks | AA01FS11 | DO-264 98% | 10mg | $157 | 2026-05-30 | Buy |
| ACHEMBLOCK | T99517 | DO-264 98% | 5MG | $145 | 2026-05-27 | Buy |
| ACHEMBLOCK | T99517 | DO-264 98% | 25MG | $525 | 2026-05-27 | Buy |
| ACHEMBLOCK | T99517 | DO-264 98% | 100MG | $1260 | 2026-05-27 | Buy |
| AK Scientific | 8011EL | CID134813646 | 1mg | $179 | 2021-12-16 | Buy |
| Arctom | HY-114157 | DO-264 99.96% | 10mM*1mLinDMSO(Solid+Solvent) | $167 | 2026-05-26 | Buy |
| Arctom | HY-114157 | DO-264 99.96% | 10mM*1mLinDMSO(Solution) | $175 | 2026-05-26 | Buy |
| Arctom | HY-114157 | DO-264 99.96% | 10mg | $238 | 2026-05-26 | Buy |
| Arctom | HY-114157 | DO-264 99.96% | 5mg | $143 | 2026-05-26 | Buy |
| Arctom | HY-114157 | DO-264 99.96% | 100mg | $1254 | 2026-05-26 | Buy |
| Arctom | HY-114157 | DO-264 99.96% | 25mg | $494 | 2026-05-26 | Buy |
| Arctom | HY-114157 | DO-264 99.96% | 50mg | $789 | 2026-05-26 | Buy |
| Axon Medchem | Axon2982 | DO264 | 25mg | $511.5 | 2026-05-19 | Buy |
| Axon Medchem | Axon2982 | DO264 | 5mg | $137.5 | 2026-05-19 | Buy |
Properties
Boiling point :601.5±65.0 °C(Predicted)
Density :1.52±0.1 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Soluble in DMSO (up to 30 mg/ml).
form :solid
pka :11.53±0.70(Predicted)
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Density :1.52±0.1 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Soluble in DMSO (up to 30 mg/ml).
form :solid
pka :11.53±0.70(Predicted)
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Safety Information
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Description
DO264 is an inhibitor of α/β-hydrolase domain-containing protein 12 (ABHD12; IC50 = 11 nM). It inhibits ABHD12-dependent hydrolysis of lysophosphatidylserine (lyso-PS) in mouse brain membrane lysates (IC50 = 2.8 nM) and human THP-1 cells. DO264 increases levels of chemokine (C-C motif) ligand 3 (CCL3), CCL4, TNF-α, and IL-1β in M1-polarized THP-1 macrophages. It potentiates ferroptotic cell death induced by the glutathione peroxidase 4 (GPX4) inhibitor RSL3 in HT1080 fibrosarcoma and SU-DHL-5 B cell lymphoma cells when used at a concentration of 1 μM. In vivo, DO264 (30 mg/kg per day for four weeks) increases levels of 1-stearoyl-2-hydroxy-sn-glycero-3-PS, 1-arachidonoyl-2-hydroxy-sn-glycero-3-PS, 1-docosanoyl-2-hydroxy-sn-glycero-3-PS, 1-stearoyl-2-arachidonoyl-sn-glycero-3-PS, and 1-oleoyl-2-arachidonoyl-sn-glycero-3-PS in mouse brain. It increases levels of CCL2, CCL3, and CCL5 in bronchoalveolar lavage fluid (BALF) and decreases survival in a mouse model of infection with lymphocytic choriomeningitis virus (LCMV) clone 13 when administered at a dose of 30 mg/kg.Related product price
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