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ChemicalBook >> CAS DataBase List >> Dutasteride

Dutasteride

Dutasteride price.
  • $50 - $1732.5
  • Product name: Dutasteride
  • CAS: 164656-23-9
  • MF: C27H30F6N2O2
  • MW: 528.53
  • EINECS:638-758-5
  • MDL Number:MFCD00937869
  • Synonyms:(1S,2R,7R,10S,11S,14S,15S)-N-[2,5-bis(trifluoroMethyl)phenyl]-2,15-diMethyl-5-oxo-6-azatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-3-ene-14-carboxaMide;(4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoroMethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-diMethyl-2-oxo-1H-Indeno[5,4-f]quinoline-7-carboxaMide;(5α,17β)-;(4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoroMethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-diMethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxaMide-13C6;6β-Hydroxy Dutasteride;4-Azaandrost-1-ene-17-carboxaMide, N-[2,5-bis(trifluoroMethyl)phenyl]-3-oxo-, (5a,17b)-;Avolve;Dutasteride API
27 prices
Selected condition:
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 1mg
  • 250mg
  • 1g
  • 200mg
  • y0001598
  • y0001603
  • 5MG
  • 10MG
  • 100MG
  • 500mg
  • 50mg
  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product numberJ10036
  • Product descriptionDutasteride
  • Packaging50mg
  • Price$161
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ95466
  • Product descriptionDutasteride
  • Packaging500mg
  • Price$181
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberF281
  • Product descriptionDutasteride
  • Packaging500mg
  • Price$242
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberSHG0006453
  • Product descriptionDUTASTERIDE 95.00%
  • Packaging5MG
  • Price$550
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberSHG0006453
  • Product descriptionDUTASTERIDE 95.00%
  • Packaging10MG
  • Price$721.88
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberSHG0006453
  • Product descriptionDUTASTERIDE 95.00%
  • Packaging100MG
  • Price$1732.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1659
  • Product descriptionDutasteride
  • Packaging10mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1659
  • Product descriptionDutasteride
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBD164398
  • Product descriptionDutasteride
  • Packaging10mg
  • Price$54
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBD164398
  • Product descriptionDutasteride
  • Packaging50mg
  • Price$108
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15956
  • Product descriptionDutasteride ≥98%
  • Packaging5mg
  • Price$68
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15956
  • Product descriptionDutasteride ≥98%
  • Packaging10mg
  • Price$130
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15956
  • Product descriptionDutasteride ≥98%
  • Packaging50mg
  • Price$370
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15956
  • Product descriptionDutasteride ≥98%
  • Packaging100mg
  • Price$669
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1542
  • Product descriptionDutasteride 99.75%
  • Packaging10mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1542
  • Product descriptionDutasteride 99.75%
  • Packaging50mg
  • Price$120
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J10036 Dutasteride 50mg $161 2021-12-16 Buy
AK Scientific J95466 Dutasteride 500mg $181 2021-12-16 Buy
AK Scientific F281 Dutasteride 500mg $242 2021-12-16 Buy
American Custom Chemicals Corporation SHG0006453 DUTASTERIDE 95.00% 5MG $550 2021-12-16 Buy
American Custom Chemicals Corporation SHG0006453 DUTASTERIDE 95.00% 10MG $721.88 2021-12-16 Buy
American Custom Chemicals Corporation SHG0006453 DUTASTERIDE 95.00% 100MG $1732.5 2021-12-16 Buy
ApexBio Technology A1659 Dutasteride 10mg $50 2021-12-16 Buy
ApexBio Technology A1659 Dutasteride 10mM(in 1mL DMSO) $55 2021-12-16 Buy
Biosynth Carbosynth BD164398 Dutasteride 10mg $54 2021-12-16 Buy
Biosynth Carbosynth BD164398 Dutasteride 50mg $108 2021-12-16 Buy
Cayman Chemical 15956 Dutasteride ≥98% 5mg $68 2024-03-01 Buy
Cayman Chemical 15956 Dutasteride ≥98% 10mg $130 2024-03-01 Buy
Cayman Chemical 15956 Dutasteride ≥98% 50mg $370 2024-03-01 Buy
Cayman Chemical 15956 Dutasteride ≥98% 100mg $669 2024-03-01 Buy
ChemScene CS-1542 Dutasteride 99.75% 10mg $60 2021-12-16 Buy
ChemScene CS-1542 Dutasteride 99.75% 50mg $120 2021-12-16 Buy

Properties

Melting point :242-250°C
Boiling point :620.3±55.0 °C(Predicted)
Density :1.303±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble2mg/mL, clear
pka :13.32±0.70(Predicted)
form :powder
color :white to beige
optical activity :[α]/D +18 to +24°, c = 1 in chloroform-d
BCS Class :2/4
InChIKey :JWJOTENAMICLJG-QWBYCMEYSA-N
SMILES :N1[C@@]2([H])[C@@](C)([C@@]3([H])CC[C@@]4(C)[C@]([H])([C@]3([H])CC2)CC[C@@H]4C(NC2=CC(C(F)(F)F)=CC=C2C(F)(F)F)=O)C=CC1=O

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

5α-reductase catalyzes the NADPH-dependent reduction of Δ4,5 double bonds in several steroid substrates, including testosterone , which is converted to dihydrotestosterone, the primary mediator of prostate growth. The 5α-reductase enzymes responsible for the reduction of testosterone to dihydrotestosterone exist as two forms: type I, which occurs in the skin, liver, and ventral prostate and type II, which is expressed in ventral prostate, epididymis, and other reproductive tissues. Dutasteride is a time-dependent, dual inhibitor of 5α-reductase (apparent Kis = 17 and 4.3 nM at 10 and 30 minute reaction times, respectively) that is frequently used in the treatment of benign prostatic hyperplasia. Compared to finasteride , a selective inhibitor of type II 5α-reductase, dutasteride has a greater terminal half-life (1 vs. 14 hours in rat, respectively) and is more effective at decreasing serum levels of dihydrotestosterone at single doses > 10 mg. Dutasteride has also been used as a strategy to reduce androgen levels related to prostate tumor burden on androgen receptor activity.

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