Dutasteride manufacturers and suppliers

Dutasteride suppliers

Properties

Melting point:: 242-250°C

Boiling point:: 620.3±55.0 °C(Predicted)

Density: 1.303±0.06 g/cm3(Predicted)

storage temp.: -20°C

solubility: DMSO: soluble2mg/mL, clear

pka: 13.32±0.70(Predicted)

form: powder

color: white to beige

optical activity: [α]/D +18 to +24°, c = 1 in chloroform-d

BCS Class: 2/4

InChIKey: JWJOTENAMICLJG-QWBYCMEYSA-N

SMILES: N1[C@@]2([H])[C@@](C)([C@@]3([H])CC[C@@]4(C)[C@]([H])([C@]3([H])CC2)CC[C@@H]4C(NC2=CC(C(F)(F)F)=CC=C2C(F)(F)F)=O)C=CC1=O

Safety Information

Symbol(GHS): GHS08

Signal word: Danger

Hazard statements: H351-H360FD

Precautionary statements: P201-P202-P280-P308+P313-P405-P501

WGK Germany: WGK 3

HS Code: 2937290000

Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications: Carc. 2
Repr. 1B

Use

Dutasteride was launched for the symptomatic treatment of benign prostatic hyperplasia. Dutasteride can be prepared from 3-oxo-4-androstene-17β-carboxylic acid by several ways in 6 or 8 steps. Dutasteride is a dual inhibitor of type 1 and 2 isoforms of 5α-reductase unlike finasteride, the first marketed 5α-reductase inhibitor, which only acts on type 2 isozyme. Dutasteride is a 3-fold greater inhibitor of type-2 5α-reductase than finasteride in men and has greater effect on the type-l than on type-2 isozyme. In animal models,dutasteride exhibited superior efficacy and pharmacokinetics compared to finasteride.

You can find Dutasteride suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.