IMR-1
|
- $11 - $1600
- Product name: IMR-1
- CAS: 310456-65-6
- MF: C15H15NO5S2
- MW: 353.42
- EINECS:-0
- MDL Number:MFCD04141288
- Synonyms:IMR-1;[2-Methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]acetic acid ethyl ester;IMR-1, >98%;Acetic acid, 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-, ethyl ester;IMR-1 >=98% (HPLC);2-Methoxy-4-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenoxy]-acetic acid ethyl ester;IMR 1,IMR1,IMR-1,Notch,Inhibitor,inhibit;2-Methoxy-4-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenoxy]-acetic acid ethyl este，IMR-1
41 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Ambeed
- ApexBio Technology
- Arctom
- AvaChem
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 5mg
- 10mM*1mLinDMSO(Solution)
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1G
- 5 mg
- 25 mg
- Manufactureraablocks
- Product numberAA00BF4R
- Product descriptionEthyl 2-(2-methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetate 98%
- Packaging1mg
- Price$11
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF4R
- Product descriptionEthyl 2-(2-methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetate 98%
- Packaging5mg
- Price$20
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF4R
- Product descriptionEthyl 2-(2-methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetate 98%
- Packaging10mg
- Price$27
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF4R
- Product descriptionEthyl 2-(2-methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetate 98
- Packaging100mg
- Price$267
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF4R
- Product descriptionEthyl 2-(2-methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetate 98
- Packaging200mg
- Price$376
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33919
- Product descriptionIMR-1 98%
- Packaging100MG
- Price$130
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33919
- Product descriptionIMR-1 98%
- Packaging1G
- Price$785
- Updated2026-05-27
- Buy
- ManufacturerAmbeed
- Product numberA802072
- Product descriptionIMR-1 97%
- Packaging10mg
- Price$162
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA802072
- Product descriptionIMR-1 97%
- Packaging5mg
- Price$96
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA802072
- Product descriptionIMR-1 97%
- Packaging25mg
- Price$274
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA802072
- Product descriptionIMR-1 97%
- Packaging50mg
- Price$357
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6110
- Product descriptionIMR-1
- Packaging100mg
- Price$818
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6110
- Product descriptionIMR-1
- Packaging25mg
- Price$214
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6110
- Product descriptionIMR-1
- Packaging5mg
- Price$71
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-100431
- Product descriptionIMR-1 98.95%
- Packaging25mg
- Price$225
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-100431
- Product descriptionIMR-1 98.95%
- Packaging10mg
- Price$100
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00BF4R | Ethyl 2-(2-methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetate 98% | 1mg | $11 | 2026-05-28 | Buy |
| aablocks | AA00BF4R | Ethyl 2-(2-methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetate 98% | 5mg | $20 | 2026-05-28 | Buy |
| aablocks | AA00BF4R | Ethyl 2-(2-methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetate 98% | 10mg | $27 | 2026-05-28 | Buy |
| aablocks | AA00BF4R | Ethyl 2-(2-methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetate 98 | 100mg | $267 | 2026-05-28 | Buy |
| aablocks | AA00BF4R | Ethyl 2-(2-methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetate 98 | 200mg | $376 | 2026-05-28 | Buy |
| ACHEMBLOCK | O33919 | IMR-1 98% | 100MG | $130 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33919 | IMR-1 98% | 1G | $785 | 2026-05-27 | Buy |
| Ambeed | A802072 | IMR-1 97% | 10mg | $162 | 2021-12-16 | Buy |
| Ambeed | A802072 | IMR-1 97% | 5mg | $96 | 2021-12-16 | Buy |
| Ambeed | A802072 | IMR-1 97% | 25mg | $274 | 2021-12-16 | Buy |
| Ambeed | A802072 | IMR-1 97% | 50mg | $357 | 2021-12-16 | Buy |
| ApexBio Technology | B6110 | IMR-1 | 100mg | $818 | 2026-05-06 | Buy |
| ApexBio Technology | B6110 | IMR-1 | 25mg | $214 | 2026-05-06 | Buy |
| ApexBio Technology | B6110 | IMR-1 | 5mg | $71 | 2026-05-06 | Buy |
| Arctom | HY-100431 | IMR-1 98.95% | 25mg | $225 | 2026-05-26 | Buy |
| Arctom | HY-100431 | IMR-1 98.95% | 10mg | $100 | 2026-05-26 | Buy |
Properties
Density :1.411±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. :2-8°C(protect from light)
solubility :Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 9 mg/ml with warming).
form :solid
pka :7.611±0.50(predicted)
color :Yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChI :1S/C15H15NO5S2/c1-3-20-13(17)8-21-10-5-4-9(6-11(10)19-2)7-12-14(18)16-15(22)23-12/h4-7H,3,8H2,1-2H3,(H,16,18,22)
InChIKey :QHPJWPQRZMBKTG-UHFFFAOYSA-N
SMILES :O=C(OCC)COC1=CC=C(C=C2SC(NC2=O)=S)C=C1OC
storage temp. :2-8°C(protect from light)
solubility :Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 9 mg/ml with warming).
form :solid
pka :7.611±0.50(predicted)
color :Yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChI :1S/C15H15NO5S2/c1-3-20-13(17)8-21-10-5-4-9(6-11(10)19-2)7-12-14(18)16-15(22)23-12/h4-7H,3,8H2,1-2H3,(H,16,18,22)
InChIKey :QHPJWPQRZMBKTG-UHFFFAOYSA-N
SMILES :O=C(OCC)COC1=CC=C(C=C2SC(NC2=O)=S)C=C1OC
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
Inhibitor of Mastermind Recruitment-1 (IMR-1, 310456-65-6) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription.1IC50=26 μM (in vitro assay). IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethyl ester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 μM (in vitroassay). Binding of IMR-1 to NTC is non-covalent and reversible.1Related product price
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Suppliers and manufacturers
Shanghai Boyle Chemical Co., Ltd.
Dalian Meilun Biotech Co., Ltd.
EnliPharma Technology Co., Ltd
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Zhengzhou Saifun Biotechnology Co., Ltd.
Shanghai EFE Biological Technology Co., Ltd.
Shanghai YuanYe Biotechnology Co., Ltd.
Tianjin Kailiqi Biotechnology Co., Ltd.
ShangHai Biochempartner Co.,Ltd
Shanghai Chaolan Chemical Technology Center