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ChemicalBook >> CAS DataBase List >> Loratadine

Loratadine

Loratadine price.
  • $10 - $2887.5
  • Product name: Loratadine
  • CAS: 79794-75-5
  • MF: C22H23ClN2O2
  • MW: 382.88
  • EINECS:935-907-9
  • MDL Number:MFCD00672869
  • Synonyms:LORATADINE;LORATADINE-D5;4-(8-Chloro-10,11-dihydro-4-aza-5H-dibenzo[a,d]cycloheptene-5-ylidene)piperidine-1-carboxylic acid ethyl ester;4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridine-11-ylidene)piperidine-1-carboxylic acid ethyl ester;Loratadine,4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester, Loratidine;anium wilfordii Maxim;4(8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLATE;4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER
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  • AHH
  • AK Scientific
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  • American Custom Chemicals Corporation
  • ApexBio Technology
  • AvaChem
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  • y0000688
  • ManufacturerAHH
  • Product numberAPI-1744
  • Product descriptionLoratadine 98%
  • Packaging25g
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ95747
  • Product descriptionLoratadine
  • Packaging1g
  • Price$10
  • Updated2021-12-16
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  • ManufacturerAK Scientific
  • Product numberG291
  • Product descriptionLoratadine
  • Packaging5g
  • Price$25
  • Updated2021-12-16
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  • ManufacturerAK Scientific
  • Product numberG291
  • Product descriptionLoratadine
  • Packaging500g
  • Price$534
  • Updated2021-12-16
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  • ManufacturerAlfa Aesar
  • Product numberJ60190
  • Product descriptionLoratadine, 98+%
  • Packaging500mg
  • Price$90.65
  • Updated2024-03-01
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  • ManufacturerAlfa Aesar
  • Product numberJ60190
  • Product descriptionLoratadine, 98+%
  • Packaging1g
  • Price$150.65
  • Updated2024-03-01
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  • ManufacturerAlfa Aesar
  • Product numberJ60190
  • Product descriptionLoratadine, 98+%
  • Packaging5g
  • Price$561.65
  • Updated2024-03-01
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0003212
  • Product descriptionLORATADINE 95.00%
  • Packaging100MG
  • Price$401.98
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0003212
  • Product descriptionLORATADINE 95.00%
  • Packaging1G
  • Price$419.8
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberRDL0006911
  • Product descriptionLORATADINE-D5 95.00%
  • Packaging1MG
  • Price$866.25
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberRDL0006911
  • Product descriptionLORATADINE-D5 95.00%
  • Packaging10MG
  • Price$2887.5
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA2960
  • Product descriptionLoratadine
  • Packaging5mg
  • Price$40
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA2960
  • Product descriptionLoratadine
  • Packaging100mg
  • Price$190
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number2987
  • Product descriptionLoratadine
  • Packaging250mg
  • Price$39
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number2987
  • Product descriptionLoratadine
  • Packaging1g
  • Price$59
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2987
  • Product descriptionLoratadine
  • Packaging10g
  • Price$290
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH API-1744 Loratadine 98% 25g $400 2021-12-16 Buy
AK Scientific J95747 Loratadine 1g $10 2021-12-16 Buy
AK Scientific G291 Loratadine 5g $25 2021-12-16 Buy
AK Scientific G291 Loratadine 500g $534 2021-12-16 Buy
Alfa Aesar J60190 Loratadine, 98+% 500mg $90.65 2024-03-01 Buy
Alfa Aesar J60190 Loratadine, 98+% 1g $150.65 2024-03-01 Buy
Alfa Aesar J60190 Loratadine, 98+% 5g $561.65 2024-03-01 Buy
American Custom Chemicals Corporation API0003212 LORATADINE 95.00% 100MG $401.98 2021-12-16 Buy
American Custom Chemicals Corporation API0003212 LORATADINE 95.00% 1G $419.8 2021-12-16 Buy
American Custom Chemicals Corporation RDL0006911 LORATADINE-D5 95.00% 1MG $866.25 2021-12-16 Buy
American Custom Chemicals Corporation RDL0006911 LORATADINE-D5 95.00% 10MG $2887.5 2021-12-16 Buy
ApexBio Technology A2960 Loratadine 5mg $40 2021-12-16 Buy
ApexBio Technology A2960 Loratadine 100mg $190 2021-12-16 Buy
AvaChem 2987 Loratadine 250mg $39 2021-12-16 Buy
AvaChem 2987 Loratadine 1g $59 2021-12-16 Buy
AvaChem 2987 Loratadine 10g $290 2021-12-16 Buy

Properties

Melting point :134-136°C
Boiling point :531.3±50.0 °C(Predicted)
Density :1.261±0.06 g/cm3(Predicted)
RTECS :TM6129200
storage temp. :2-8°C
solubility :DMSO: 26 mg/mL, soluble
form :powder
pka :4.27±0.20(Predicted)
color :white
Water Solubility :It is soluble in DMSO (50 mg/ml), ethanol (77 mg/ml at 25°C), water (<1 mg/ml at 25°C), chloroform, and methanol.
Merck :14,5578
BCS Class :2
Stability :Stable, but may be heat sensitive - refrigerate. Incompatible with strong oxidizing agents.
InChIKey :JCCNYMKQOSZNPW-UHFFFAOYSA-N
CAS DataBase Reference :79794-75-5(CAS DataBase Reference)
EPA Substance Registry System :1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester (79794-75-5)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

Loratadine is a non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM). It has been shown to inhibit the release of leukotriene C4 (IC50 = 8 μM) and histamine (IC50 = 11 μM) from rodent mast cells and to inhibit allergic bronchospasm in guinea pigs with an ED50 value of 0.40 mg/kg.

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