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ChemicalBook >> CAS DataBase List >> Nateglinide

Nateglinide

Nateglinide price.
  • $5 - $1900
  • Product name: Nateglinide
  • CAS: 105816-04-4
  • MF: C19H27NO3
  • MW: 317.42
  • EINECS:641-756-7
  • MDL Number:MFCD00875706
  • Synonyms:(-)-n-(trans-4-isopropylcyclohexanecarbonyl)-d-phenylalanine ;ay4166 ;Nateglinide(H) ;trans-d-phenylalanin ;trans-d-phenylalanine;NATAGLINIDE;Nateglinide (200 mg);Glinate
45 prices
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Brand
  • AHH
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • AvaChem
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
  • TRC
  • Usbiological
Package
  • 1mg
  • 100mg
  • 250mg
  • 500mg
  • 10
  • 50
  • y0001437
  • 200mg
  • 10mM(in 1mL DMSO)
  • 1unit
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 1g
  • 5g
  • 25g
  • ManufacturerAHH
  • Product numberAPI-1474
  • Product descriptionNateglinide 98%
  • Packaging1g
  • Price$710
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberD898
  • Product descriptionNateglinide
  • Packaging1g
  • Price$54
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ95201
  • Product descriptionNateglinide
  • Packaging5g
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA686242
  • Product description(R)-2-rel-((1r,4R)-4-Isopropylcyclohexanecarboxamido)-3-phenylpropanoicacid 99%
  • Packaging5mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA686242
  • Product description(R)-2-rel-((1r,4R)-4-Isopropylcyclohexanecarboxamido)-3-phenylpropanoicacid 99%
  • Packaging10mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA686242
  • Product description(R)-2-rel-((1r,4R)-4-Isopropylcyclohexanecarboxamido)-3-phenylpropanoicacid 99%
  • Packaging25mg
  • Price$8
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA686242
  • Product description(R)-2-rel-((1r,4R)-4-Isopropylcyclohexanecarboxamido)-3-phenylpropanoicacid 99%
  • Packaging50mg
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA686242
  • Product description(R)-2-rel-((1r,4R)-4-Isopropylcyclohexanecarboxamido)-3-phenylpropanoicacid 99%
  • Packaging5g
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA686242
  • Product description(R)-2-rel-((1r,4R)-4-Isopropylcyclohexanecarboxamido)-3-phenylpropanoicacid 99%
  • Packaging25g
  • Price$89
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2198
  • Product descriptionNateglinide
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2198
  • Product descriptionNateglinide
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2198
  • Product descriptionNateglinide
  • Packaging10mg
  • Price$68
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2198
  • Product descriptionNateglinide
  • Packaging25mg
  • Price$119
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2263
  • Product descriptionNateglinide
  • Packaging100mg
  • Price$89
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2263
  • Product descriptionNateglinide
  • Packaging1g
  • Price$189
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2263
  • Product descriptionNateglinide
  • Packaging5g
  • Price$630
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH API-1474 Nateglinide 98% 1g $710 2021-12-16 Buy
AK Scientific D898 Nateglinide 1g $54 2021-12-16 Buy
AK Scientific J95201 Nateglinide 5g $100 2021-12-16 Buy
Ambeed A686242 (R)-2-rel-((1r,4R)-4-Isopropylcyclohexanecarboxamido)-3-phenylpropanoicacid 99% 5mg $5 2021-12-16 Buy
Ambeed A686242 (R)-2-rel-((1r,4R)-4-Isopropylcyclohexanecarboxamido)-3-phenylpropanoicacid 99% 10mg $6 2021-12-16 Buy
Ambeed A686242 (R)-2-rel-((1r,4R)-4-Isopropylcyclohexanecarboxamido)-3-phenylpropanoicacid 99% 25mg $8 2021-12-16 Buy
Ambeed A686242 (R)-2-rel-((1r,4R)-4-Isopropylcyclohexanecarboxamido)-3-phenylpropanoicacid 99% 50mg $10 2021-12-16 Buy
Ambeed A686242 (R)-2-rel-((1r,4R)-4-Isopropylcyclohexanecarboxamido)-3-phenylpropanoicacid 99% 5g $30 2021-12-16 Buy
Ambeed A686242 (R)-2-rel-((1r,4R)-4-Isopropylcyclohexanecarboxamido)-3-phenylpropanoicacid 99% 25g $89 2021-12-16 Buy
ApexBio Technology B2198 Nateglinide 1unit $28 2021-12-16 Buy
ApexBio Technology B2198 Nateglinide 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology B2198 Nateglinide 10mg $68 2021-12-16 Buy
ApexBio Technology B2198 Nateglinide 25mg $119 2021-12-16 Buy
AvaChem 2263 Nateglinide 100mg $89 2021-12-16 Buy
AvaChem 2263 Nateglinide 1g $189 2021-12-16 Buy
AvaChem 2263 Nateglinide 5g $630 2021-12-16 Buy

Properties

Melting point :137-141°C
alpha :D20 -9.4° (c = 1 in methanol)
Boiling point :527.6±39.0 °C(Predicted)
Density :1.104±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: >5mg/mL
pka :3.61±0.10(Predicted)
form :solid
color :white to off-white
Merck :14,6428
CAS DataBase Reference :105816-04-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Nateglinide is a N-acylated D-phenylalanine marketed in Japan as novel orally active insulinotropic agent for the treatment of type-2 diabetes mellitus. It belongs to the class of nonsulfonylureas and shows some structural similarity to repaglinide, the only other representative in this family. In single pancreatic beta-cells isolated from rats, Nateglinide was found to specifically block the ATP-sensitive K+ channel resulting in an increase in intracellular calcium concentration. This primary action would underlie the mechanism by which Nateglinide markedly stimulates or potentiates, depending on glucose concentrations, insulin secretion from pancreatic beta-cells. Clinical studies demonstrated a good safety profile with a low potential for hypoglycemia. The pharmacokinetic profile was consistent with the changes of the blood glucose and plasma insulin level. Interestingly, Nateglinide exerts a rapid onset and short duration of action due to a rapid absorption and clearance. Unlike other similar agents, Nateglinide suppresses postprandial glucose elevations.

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