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ChemicalBook >> CAS DataBase List >> Nilotinib

Nilotinib

Nilotinib price.
  • $25 - $960
  • Product name: Nilotinib
  • CAS: 641571-10-0
  • MF: C28H22F3N7O
  • MW: 529.52
  • EINECS:700-544-5
  • MDL Number:MFCD09833716
  • Synonyms:Nilotinib;Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-;Nilotinib(TINIBS );4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide;4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)benzamide;Nilotinib & its intermediates;Nilotinib for research;Nilotinib(AMN 107)
39 prices
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Brand

  • AccelPharmtech
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • TRC
  • Usbiological

Package

  • 1mg
  • 5MG
  • 10mg
  • 20mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 500mg
  • 1g
  • 2g
  • 5g
  • 10G
  • 25g
  • ManufacturerAccelPharmtech
  • Product numberAT8434
  • Product descriptionNilotinib 99.00%
  • Packaging10G
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1057-M010
  • Product descriptionNilotinib ≥95%
  • Packaging10mg
  • Price$108
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ51374
  • Product descriptionNilotinib
  • Packaging5g
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ51374
  • Product descriptionNilotinib
  • Packaging10g
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberV0705
  • Product descriptionNilotinib
  • Packaging25g
  • Price$801
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ11241
  • Product descriptionNilotinib
  • Packaging5g
  • Price$960
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberRDL0007002
  • Product descriptionNILOTINIB-D6 95.00%
  • Packaging5MG
  • Price$499.79
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8232
  • Product descriptionNilotinib(AMN-107)
  • Packaging100mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8232
  • Product descriptionNilotinib(AMN-107)
  • Packaging500mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60185
  • Product descriptionNilotinib(AMN-107) ≥98%
  • Packaging20mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2162
  • Product descriptionNilotinib
  • Packaging100mg
  • Price$35
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2162
  • Product descriptionNilotinib
  • Packaging250mg
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2162
  • Product descriptionNilotinib
  • Packaging1g
  • Price$115
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2162
  • Product descriptionNilotinib
  • Packaging5g
  • Price$375
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1396
  • Product descriptionNilotinib-AMN107|Tasigna 99%
  • Packaging5mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb546000
  • Product descriptionNilotinib >98%
  • Packaging10mg
  • Price$119
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AccelPharmtech AT8434 Nilotinib 99.00% 10G $180 2021-12-16 Buy
Adipogen Life Sciences SYN-1057-M010 Nilotinib ≥95% 10mg $108 2021-12-16 Buy
AK Scientific J51374 Nilotinib 5g $190 2021-12-16 Buy
AK Scientific J51374 Nilotinib 10g $300 2021-12-16 Buy
AK Scientific V0705 Nilotinib 25g $801 2021-12-16 Buy
AK Scientific J11241 Nilotinib 5g $960 2021-12-16 Buy
American Custom Chemicals Corporation RDL0007002 NILOTINIB-D6 95.00% 5MG $499.79 2021-12-16 Buy
ApexBio Technology A8232 Nilotinib(AMN-107) 100mg $50 2021-12-16 Buy
ApexBio Technology A8232 Nilotinib(AMN-107) 500mg $120 2021-12-16 Buy
Arctom CFN60185 Nilotinib(AMN-107) ≥98% 20mg $50 2021-12-16 Buy
AvaChem 2162 Nilotinib 100mg $35 2021-12-16 Buy
AvaChem 2162 Nilotinib 250mg $45 2021-12-16 Buy
AvaChem 2162 Nilotinib 1g $115 2021-12-16 Buy
AvaChem 2162 Nilotinib 5g $375 2021-12-16 Buy
Axon Medchem Axon1396 Nilotinib-AMN107|Tasigna 99% 5mg $55 2021-12-16 Buy
Biorbyt Ltd orb546000 Nilotinib >98% 10mg $119 2021-12-16 Buy

Properties

Melting point :231-233 °C
Density :1.36
storage temp. :-20°C Freezer
solubility :Soluble in DMSO (up to 50 mg/ml)
form :Beige powder.
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :HHZIURLSWUIHRB-UHFFFAOYSA-N
SMILES :N1(C=C(C)N=C1)C1C=C(C=C(C=1)NC(=O)C1C=CC(C)=C(NC2=NC=CC(C3=CC=CN=C3)=N2)C=1)C(F)(F)F
CAS DataBase Reference :641571-10-0(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Nilotinib is the other second-generation Abl kinase inhibitor approved for treatment of patients with CML. Nilotinib has increased affinity for the Abl kinase compared with imatinib, binding with an improved topologic fit to the kinase site in its inactive form.Nilotinib is active in chronic and accelerated phase CML patients who have developed resistance to imatinib. As with dasatinib, nilotinib was compared with imatinib in a phase III randomized trial as initial therapy for chronic phase CML patients, with nilotinib achieving higher rates of complete cytogenetic and major molecular responses and with fewer cases of disease progression or clonal evolution in the nilotinib-treated cohorts. Survival outcomes were similar in all arms. Common adverse events with nilotinib included rash, gastrointestinal disturbances (nausea, vomiting, diarrhea), neutropenia, and thrombocytopenia. Pleural effusion and peripheral edema are less common than with dasatinib. In addition, QT prolongation and a risk of pancreatitis are serious side effects of nilotinib.

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