PD184352
|
- $20 - $2120
- Product name: PD184352
- CAS: 212631-79-3
- MF: C17H14ClF2IN2O2
- MW: 478.66
- EINECS:
- MDL Number:MFCD02683961
- Synonyms:PD184352;2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide;2-(2-CHLORO-4-IODOANILINO)-N-(CYCLOPROPYLMETHOXY)-3,4-DIFLUOROBENZAMIDE;2-[(2-CHLORO-4-IODOPHENYL) AMINO]-N-(CYCLOPROPYLME;Benzamide, 2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-;Ci-1040;CI-1040, PD-184352;3,4-Difluoro-2-(2-chloro-4-iodophenylaMino)-N-cyclopropylMethoxybenzaMide
55 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- CSNpharm
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 50
- 2x5mg
- 10
- 1mg
- 5mg
- 10mg
- 20mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- 10mM(in 1mL DMSO)
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0029-M001
- Product descriptionPD 184352 ≥95%(HPLC,NMR)
- Packaging1mg
- Price$20
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7396
- Product descriptionPD 184352
- Packaging5mg
- Price$49
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7396
- Product descriptionPD 184352
- Packaging50mg
- Price$324
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA832312
- Product descriptionCI-1040 98+%
- Packaging5mg
- Price$41
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA832312
- Product descriptionCI-1040 98+%
- Packaging10mg
- Price$66
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA832312
- Product descriptionCI-1040 98+%
- Packaging25mg
- Price$114
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA832312
- Product descriptionCI-1040 98+%
- Packaging50mg
- Price$148
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA832312
- Product descriptionCI-1040 98+%
- Packaging100mg
- Price$267
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA832312
- Product descriptionCI-1040 98+%
- Packaging250mg
- Price$411
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA832312
- Product descriptionCI-1040 98+%
- Packaging1g
- Price$1003
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0008608
- Product descriptionPD 184352 95.00%
- Packaging1MG
- Price$166.95
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0008608
- Product descriptionPD 184352 95.00%
- Packaging10MG
- Price$739.2
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0008608
- Product descriptionPD 184352 95.00%
- Packaging100MG
- Price$1871.1
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1792
- Product descriptionPD184352(CI-1040)
- Packaging5mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1792
- Product descriptionPD184352(CI-1040)
- Packaging10mM(in 1mL DMSO)
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1792
- Product descriptionPD184352(CI-1040)
- Packaging25mg
- Price$180
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-0029-M001 | PD 184352 ≥95%(HPLC,NMR) | 1mg | $20 | 2021-12-16 | Buy |
| AK Scientific | X7396 | PD 184352 | 5mg | $49 | 2021-12-16 | Buy |
| AK Scientific | X7396 | PD 184352 | 50mg | $324 | 2021-12-16 | Buy |
| Ambeed | A832312 | CI-1040 98+% | 5mg | $41 | 2021-12-16 | Buy |
| Ambeed | A832312 | CI-1040 98+% | 10mg | $66 | 2021-12-16 | Buy |
| Ambeed | A832312 | CI-1040 98+% | 25mg | $114 | 2021-12-16 | Buy |
| Ambeed | A832312 | CI-1040 98+% | 50mg | $148 | 2021-12-16 | Buy |
| Ambeed | A832312 | CI-1040 98+% | 100mg | $267 | 2021-12-16 | Buy |
| Ambeed | A832312 | CI-1040 98+% | 250mg | $411 | 2021-12-16 | Buy |
| Ambeed | A832312 | CI-1040 98+% | 1g | $1003 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0008608 | PD 184352 95.00% | 1MG | $166.95 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0008608 | PD 184352 95.00% | 10MG | $739.2 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0008608 | PD 184352 95.00% | 100MG | $1871.1 | 2021-12-16 | Buy |
| ApexBio Technology | A1792 | PD184352(CI-1040) | 5mg | $50 | 2021-12-16 | Buy |
| ApexBio Technology | A1792 | PD184352(CI-1040) | 10mM(in 1mL DMSO) | $55 | 2021-12-16 | Buy |
| ApexBio Technology | A1792 | PD184352(CI-1040) | 25mg | $180 | 2021-12-16 | Buy |
Properties
Melting point :166-169°C
Density :1.747±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: ≥30mg/mL
pka :-5.58±0.50(Predicted)
form :powder
color :white to tan
Density :1.747±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: ≥30mg/mL
pka :-5.58±0.50(Predicted)
form :powder
color :white to tan
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||
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| Precautionary statements: |
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Description
The dual specific threonine/tyrosine kinase, map kinase kinase (MEK), is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. CI-1040 is a benzhydroxamate compound that potently inhibits MEK in an in vitro mitogen-activated protein kinase cascade assay with an IC50 value of 2.3 nM (Kd = 74 nM when activated with adenosine triphosphate). It can suppress phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 35 nM and demonstrates in vivo activity with oral administration in a mouse tumor model. The second-generation MEK inhibitor PD 0325901 is a structural derivative of CI-1040 that was developed for improved solubility.Related product price
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