PF-04929113
|
- $55 - $7000
- Product name: PF-04929113
- CAS: 908115-27-5
- MF: C25H30F3N5O4
- MW: 521.53
- EINECS:
- MDL Number:MFCD20526334
- Synonyms:(1r,4r)-4-(2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate;PF-04929113, >=98%;snx54227;PF04929113 SNX-54227;PF-04929113;SNX-5422;PF-04929113(SNX5422);Glycine trans-4-[[2-(aminocarbonyl)-5-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl]phenyl]amino]cyclohexyl ester
19 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Biosynth Carbosynth
- Cayman Chemical
- Crysdot
- DC Chemicals
- Labseeker
- TRC
- Usbiological
Package
- 1mg
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 10g
- ManufacturerAK Scientific
- Product numberX7589
- Product description(1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl2-aminoacetate
- Packaging10mg
- Price$434
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7589
- Product description(1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl2-aminoacetate
- Packaging50mg
- Price$1396
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008143
- Product descriptionPF-04929113 95.00%
- Packaging5MG
- Price$501.11
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008143
- Product descriptionPF-04929113 95.00%
- Packaging10MG
- Price$644.7
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4065
- Product descriptionPF-04929113(SNX-5422)
- Packaging50mg
- Price$690
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFP104240
- Product descriptionPF 04929113
- Packaging10mg
- Price$285
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFP104240
- Product descriptionPF 04929113
- Packaging50mg
- Price$997.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18270
- Product descriptionPF-04929113 ≥98%
- Packaging1mg
- Price$55
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18270
- Product descriptionPF-04929113 ≥98%
- Packaging5mg
- Price$248
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18270
- Product descriptionPF-04929113 ≥98%
- Packaging10mg
- Price$440
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18270
- Product descriptionPF-04929113 ≥98%
- Packaging25mg
- Price$963
- Updated2024-03-01
- Buy
- ManufacturerCrysdot
- Product numberCD31000319
- Product descriptionPF-04929113 98+%
- Packaging5mg
- Price$139
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000319
- Product descriptionPF-04929113 98+%
- Packaging10mg
- Price$242
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000319
- Product descriptionPF-04929113 98+%
- Packaging50mg
- Price$537
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC9948
- Product descriptionSNX-5422(PF04929113) >98%
- Packaging100mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC9948
- Product descriptionSNX-5422(PF04929113) >98%
- Packaging250mg
- Price$1200
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7589 | (1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl2-aminoacetate | 10mg | $434 | 2021-12-16 | Buy |
| AK Scientific | X7589 | (1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl2-aminoacetate | 50mg | $1396 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008143 | PF-04929113 95.00% | 5MG | $501.11 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008143 | PF-04929113 95.00% | 10MG | $644.7 | 2021-12-16 | Buy |
| ApexBio Technology | A4065 | PF-04929113(SNX-5422) | 50mg | $690 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FP104240 | PF 04929113 | 10mg | $285 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FP104240 | PF 04929113 | 50mg | $997.5 | 2021-12-16 | Buy |
| Cayman Chemical | 18270 | PF-04929113 ≥98% | 1mg | $55 | 2024-03-01 | Buy |
| Cayman Chemical | 18270 | PF-04929113 ≥98% | 5mg | $248 | 2024-03-01 | Buy |
| Cayman Chemical | 18270 | PF-04929113 ≥98% | 10mg | $440 | 2024-03-01 | Buy |
| Cayman Chemical | 18270 | PF-04929113 ≥98% | 25mg | $963 | 2024-03-01 | Buy |
| Crysdot | CD31000319 | PF-04929113 98+% | 5mg | $139 | 2021-12-16 | Buy |
| Crysdot | CD31000319 | PF-04929113 98+% | 10mg | $242 | 2021-12-16 | Buy |
| Crysdot | CD31000319 | PF-04929113 98+% | 50mg | $537 | 2021-12-16 | Buy |
| DC Chemicals | DC9948 | SNX-5422(PF04929113) >98% | 100mg | $650 | 2021-12-16 | Buy |
| DC Chemicals | DC9948 | SNX-5422(PF04929113) >98% | 250mg | $1200 | 2021-12-16 | Buy |
Properties
Melting point :298-299℃
Boiling point :646.5±55.0 °C(Predicted)
Density :1.48
storage temp. :Store at -20°C
solubility :≥23.85 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
form :solid
pka :15.07±0.50(Predicted)
Boiling point :646.5±55.0 °C(Predicted)
Density :1.48
storage temp. :Store at -20°C
solubility :≥23.85 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
form :solid
pka :15.07±0.50(Predicted)
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
PF-04929113 is a prodrug for the Hsp90 inhibitor, PF-04958473 (SNX-2112), which binds both Hsp90α and Hsp90β with an IC50 value of 30 nM. The prodrug, PF-04929113, is rapidly absorbed and converted into the active inhibitor after oral administration. The active inhibitor causes degradation of Hsp90 client proteins, including HER2, and reduces phosphorylation of downstream kinases, including Akt and ERK1/2, leading to apoptosis in cancer cells. Oral administration of the prodrug, PF-04929113, reduces tumor growth and prolongs survival in mouse models of multiple myeloma and prostate cancer.More related product prices
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