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ChemicalBook >> CAS DataBase List >> Protocatechuic acid

Protocatechuic acid

Protocatechuic acid price.
  • $6 - $2180.8
  • Product name: Protocatechuic acid
  • CAS: 99-50-3
  • MF: C7H6O4
  • MW: 154.12
  • EINECS:202-760-0
  • MDL Number:MFCD00002509
  • Synonyms:3,4-Dihydroxybenzoic acid >=97.0% (T);Carbohydroquinonic acid;3,4-Dihydroxybenzoic acid, >=99%;Benzoic acid, 3,4-dihydroxy-;PROTOCATECHUIC ACID(RG);3,4-DIHYDROXYBENZOIC ACID / PROTOCATECHUIC ACID;Protocatechuic acid ,99%;4-Carboxypyrocatechol
Price118 Properties Safety Information Description
118 prices
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  • aablocks
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  • Manufactureraablocks
  • Product numberAA003IEV
  • Product description3,4-Dihydroxybenzoic acid 98%
  • Packaging25g
  • Price$6
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003IEV
  • Product description3,4-Dihydroxybenzoic acid 98%
  • Packaging100g
  • Price$9
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA003IEV
  • Product description3,4-Dihydroxybenzoic acid 98%
  • Packaging1kg
  • Price$86
  • Updated2026-05-28
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  • ManufacturerActivate Scientific
  • Product numberAS33149
  • Product description3,4-Dihydroxybenzoic acid 98%
  • Packaging25g
  • Price$31
  • Updated2026-06-04
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  • ManufacturerActivate Scientific
  • Product numberAS33149
  • Product description3,4-Dihydroxybenzoic acid 98%
  • Packaging100g
  • Price$52
  • Updated2026-06-04
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  • ManufacturerAK Scientific
  • Product numberA141
  • Product description3,4-Dihydroxybenzoic acid >99%(HPLC)
  • Packaging25g
  • Price$27
  • Updated2026-06-04
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  • ManufacturerAK Scientific
  • Product numberJ91727
  • Product description3,4-Dihydroxybenzoic acid 98%
  • Packaging100g
  • Price$41
  • Updated2026-06-04
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  • ManufacturerAK Scientific
  • Product numberJ91727
  • Product description3,4-Dihydroxybenzoic Acid
  • Packaging5g
  • Price$10
  • Updated2021-12-16
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  • ManufacturerAK Scientific
  • Product numberJ91727
  • Product description3,4-Dihydroxybenzoic acid 98%
  • Packaging5g
  • Price$13
  • Updated2026-06-04
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  • ManufacturerAK Scientific
  • Product numberA141
  • Product description3,4-Dihydroxybenzoic acid >99%(HPLC)
  • Packaging5g
  • Price$18
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ91727
  • Product description3,4-Dihydroxybenzoic acid 98%
  • Packaging25g
  • Price$19
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberA141
  • Product description3,4-Dihydroxybenzoic acid >99%(HPLC)
  • Packaging100g
  • Price$55
  • Updated2026-06-04
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  • ManufacturerAK Scientific
  • Product numberJ91727
  • Product description3,4-Dihydroxybenzoic acid 98%
  • Packaging500g
  • Price$150
  • Updated2026-06-04
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  • ManufacturerAK Scientific
  • Product numberA141
  • Product description3,4-Dihydroxybenzoic acid >99%(HPLC)
  • Packaging500g
  • Price$199
  • Updated2026-06-04
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  • ManufacturerAK Scientific
  • Product numberJ91727
  • Product description3,4-Dihydroxybenzoic acid 98%
  • Packaging1kg
  • Price$250
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberA141
  • Product description3,4-Dihydroxybenzoic acid >99%(HPLC)
  • Packaging1kg
  • Price$334
  • Updated2026-06-04
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA003IEV 3,4-Dihydroxybenzoic acid 98% 25g $6 2026-05-28 Buy
aablocks AA003IEV 3,4-Dihydroxybenzoic acid 98% 100g $9 2026-05-28 Buy
aablocks AA003IEV 3,4-Dihydroxybenzoic acid 98% 1kg $86 2026-05-28 Buy
Activate Scientific AS33149 3,4-Dihydroxybenzoic acid 98% 25g $31 2026-06-04 Buy
Activate Scientific AS33149 3,4-Dihydroxybenzoic acid 98% 100g $52 2026-06-04 Buy
AK Scientific A141 3,4-Dihydroxybenzoic acid >99%(HPLC) 25g $27 2026-06-04 Buy
AK Scientific J91727 3,4-Dihydroxybenzoic acid 98% 100g $41 2026-06-04 Buy
AK Scientific J91727 3,4-Dihydroxybenzoic Acid 5g $10 2021-12-16 Buy
AK Scientific J91727 3,4-Dihydroxybenzoic acid 98% 5g $13 2026-06-04 Buy
AK Scientific A141 3,4-Dihydroxybenzoic acid >99%(HPLC) 5g $18 2026-06-04 Buy
AK Scientific J91727 3,4-Dihydroxybenzoic acid 98% 25g $19 2026-06-04 Buy
AK Scientific A141 3,4-Dihydroxybenzoic acid >99%(HPLC) 100g $55 2026-06-04 Buy
AK Scientific J91727 3,4-Dihydroxybenzoic acid 98% 500g $150 2026-06-04 Buy
AK Scientific A141 3,4-Dihydroxybenzoic acid >99%(HPLC) 500g $199 2026-06-04 Buy
AK Scientific J91727 3,4-Dihydroxybenzoic acid 98% 1kg $250 2026-06-04 Buy
AK Scientific A141 3,4-Dihydroxybenzoic acid >99%(HPLC) 1kg $334 2026-06-04 Buy
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Properties

Melting point :197-200 °C (dec.) (lit.)
Boiling point :237.46°C (rough estimate)
Density :1.54
refractive index :1.6400 (estimate)
FEMA :4430 | 3,4-DIHYDROXYBENZOIC ACID
storage temp. :Store below +30°C.
solubility :20g/l
pka :4.48(at 25℃)
form :Fine Crystalline Powder
color :Beige to brown
PH :3.78(1 mM solution);3.25(10 mM solution);2.74(100 mM solution)
Odor :at 100.00 %. mild phenolic balsamic
Odor Type :phenolic
Water Solubility :Soluble in hot alcohol and ether. Slightly soluble in water.
Sensitive :Air Sensitive
Merck :14,7894
JECFA Number :2278
BRN :1448841
Stability :Stable. Incompatible with strong oxidizing agents, strong bases.
Cosmetics Ingredients Functions :SKIN PROTECTING
InChI :1S/C7H6O4/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,8-9H,(H,10,11)
InChIKey :YQUVCSBJEUQKSH-UHFFFAOYSA-N
SMILES :OC(=O)c1ccc(O)c(O)c1
LogP :1.16
CAS DataBase Reference :99-50-3(CAS DataBase Reference)
EPA Substance Registry System :Protocatechuic acid (99-50-3)

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Protocatechuic acid (PCA) is a dihydroxybenzoic acid phenolic compound found in many edible and medicinal plants. It is a major metabolite of antioxidant polyphenols found in green tea and demonstrates free radical scavenging capability in a 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity assay (IC50 = 16.3 μM). It is thought to possess anti-inflammatory, antihyperglycemic, neuroprotective, and anticancer activities. Dietary administration of PCA dose dependently inhibits in vitro chemical carcinogenesis and exerts pro-apoptotic and anti-proliferative effects in different tissues. In studies of tumor cell migration and invasion using mouse melanoma B16/F10 cells, PCA at 0.1-2 mM down-regulated the Ras/Akt/NF-κB pathway by targeting RhoB activation, leading to a reduction of MMP-mediated activity.

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