SB218078
|
- $140 - $2361.3
- Product name: SB218078
- CAS: 135897-06-2
- MF: C24H15N3O3
- MW: 393.39
- EINECS:
- MDL Number:MFCD27991263
- Synonyms:9,10,11,12-Tetrahydro-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione;SB218078 ?SB-218078;9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione, 9,10,11,12-tetrahydro-;5,6,7,8-Tetrahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-13,15(14H)-dione
26 prices
Selected condition：
Brand
- aablocks
- American Custom Chemicals Corporation
- ApexBio Technology
- Biosynth
- Cayman Chemical
- ChemScene
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 1mg
- 2.5mg
- 5mg
- 10mg
- 100mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA007N2R
- Product descriptionSB 218078 ≥98%
- Packaging1mg
- Price$156
- Updated2026-05-28
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000224
- Product descriptionSB-218078 95.00%
- Packaging1MG
- Price$648.83
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC3012
- Product descriptionSB218078
- Packaging1mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC3012
- Product descriptionSB 218078
- Packaging1mg
- Price$168
- Updated2026-05-06
- Buy
- ManufacturerBiosynth
- Product numberBS162793
- Product descriptionSB 218078
- Packaging10mg
- Price$2361.3
- Updated2026-06-04
- Buy
- ManufacturerCayman Chemical
- Product number13335
- Product descriptionSB 218078 ≥98%
- Packaging1mg
- Price$156
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number13335
- Product descriptionSB 218078 ≥98%
- Packaging1mg
- Price$141
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0028421
- Product descriptionSB-218078 98.3%
- Packaging1mg
- Price$149
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-0028421
- Product descriptionSB-218078 98.3%
- Packaging1mg
- Price$149
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-0028421
- Product descriptionSB-218078 ≥98.0%
- Packaging1mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0028421
- Product descriptionSB-218078 98.3%
- Packaging5mg
- Price$374
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-0028421
- Product descriptionSB-218078 98.3%
- Packaging5mg
- Price$374
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-0028421
- Product descriptionSB-218078 ≥98.0%
- Packaging5mg
- Price$380
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0028421
- Product descriptionSB-218078 98.3%
- Packaging10mg
- Price$617
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-0028421
- Product descriptionSB-218078 98.3%
- Packaging10mg
- Price$617
- Updated2026-06-04
- Buy
- ManufacturerCSNpharm
- Product numberCSN21202
- Product descriptionSB218078
- Packaging5mg
- Price$353
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA007N2R | SB 218078 ≥98% | 1mg | $156 | 2026-05-28 | Buy |
| American Custom Chemicals Corporation | KIN0000224 | SB-218078 95.00% | 1MG | $648.83 | 2021-12-16 | Buy |
| ApexBio Technology | C3012 | SB218078 | 1mg | $160 | 2021-12-16 | Buy |
| ApexBio Technology | C3012 | SB 218078 | 1mg | $168 | 2026-05-06 | Buy |
| Biosynth | BS162793 | SB 218078 | 10mg | $2361.3 | 2026-06-04 | Buy |
| Cayman Chemical | 13335 | SB 218078 ≥98% | 1mg | $156 | 2026-04-30 | Buy |
| Cayman Chemical | 13335 | SB 218078 ≥98% | 1mg | $141 | 2024-03-01 | Buy |
| ChemScene | CS-0028421 | SB-218078 98.3% | 1mg | $149 | 2026-06-04 | Buy |
| ChemScene | CS-0028421 | SB-218078 98.3% | 1mg | $149 | 2026-06-04 | Buy |
| ChemScene | CS-0028421 | SB-218078 ≥98.0% | 1mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-0028421 | SB-218078 98.3% | 5mg | $374 | 2026-06-04 | Buy |
| ChemScene | CS-0028421 | SB-218078 98.3% | 5mg | $374 | 2026-06-04 | Buy |
| ChemScene | CS-0028421 | SB-218078 ≥98.0% | 5mg | $380 | 2021-12-16 | Buy |
| ChemScene | CS-0028421 | SB-218078 98.3% | 10mg | $617 | 2026-06-04 | Buy |
| ChemScene | CS-0028421 | SB-218078 98.3% | 10mg | $617 | 2026-06-04 | Buy |
| CSNpharm | CSN21202 | SB218078 | 5mg | $353 | 2021-12-16 | Buy |
Properties
Melting point :>340 °C
Density :1.80±0.1 g/cm3(Predicted)
storage temp. :Store at RT
solubility :≤5mg/ml in DMSO;5mg/ml in dimethyl formamide
form :crystalline solid
pka :9.75±0.20(Predicted)
color :Light yellow to yellow
InChI :1S/C24H15N3O3/c28-23-19-17-11-5-1-3-7-13(11)26-15-9-10-16(30-15)27-14-8-4-2-6-12(14)18(22(27)21(17)26)20(19)24(29)25-23/h1-8,15-16H,9-10H2,(H,25,28,29)
InChIKey :OTPNDVKVEAIXTI-UHFFFAOYSA-N
Density :1.80±0.1 g/cm3(Predicted)
storage temp. :Store at RT
solubility :≤5mg/ml in DMSO;5mg/ml in dimethyl formamide
form :crystalline solid
pka :9.75±0.20(Predicted)
color :Light yellow to yellow
InChI :1S/C24H15N3O3/c28-23-19-17-11-5-1-3-7-13(11)26-15-9-10-16(30-15)27-14-8-4-2-6-12(14)18(22(27)21(17)26)20(19)24(29)25-23/h1-8,15-16H,9-10H2,(H,25,28,29)
InChIKey :OTPNDVKVEAIXTI-UHFFFAOYSA-N
Safety Information
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Description
SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that blocks phosphorylation of cdc25 with an IC50 value of 15 nM. It less potently inhibits cdc2 and PKC (IC50s = 250 and 1,000 nM, respectively) and causes 85% inhibition of PKD1 at 1 μM. SB 218078 releases G2 cell cycle arrest induced by γ-irradiation or the topoisomerase I inhibitor topotecan . In this way, SB 218078 enhances the cytotoxicity of DNA-damaging compounds.More related product prices
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