SR8278
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- $44 - $2050
- Product name: SR8278
- CAS: 1254944-66-5
- MF: C18H19NO3S2
- MW: 361.48
- EINECS:
- MDL Number:MFCD18782736
- Synonyms:SR8278;1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester;UIEBLUZPSFAFOC-UHFFFAOYSA-N;SR8278;SR-8278;SR 8278;ethyl2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate;Ethyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate;3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-, ethyl ester;Duchenne muscular dystrophy,inhibit,metabolism,biological rhythm,Alzheimer's disease,SR-8278,SR8278,neurosurgery,Inhibitor,REV-ERBα,SR 8278,REV-ERB
19 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 50
- 10
- 1mg
- 5mg
- 10MG
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number6895DK
- Product descriptionCID53393127
- Packaging1mg
- Price$147
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0014157
- Product descriptionSR-8278 95.00%
- Packaging10MG
- Price$216.3
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5606
- Product descriptionSR8278
- Packaging10mg
- Price$229
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17000
- Product descriptionSR8278 ≥90%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17000
- Product descriptionSR8278 ≥90%
- Packaging5mg
- Price$109
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17000
- Product descriptionSR8278 ≥90%
- Packaging10mg
- Price$201
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17000
- Product descriptionSR8278 ≥90%
- Packaging25mg
- Price$443
- Updated2024-03-01
- Buy
- ManufacturerDC Chemicals
- Product numberDC21691
- Product descriptionSR8278 >98%
- Packaging100mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC21691
- Product descriptionSR8278 >98%
- Packaging250mg
- Price$950
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC21691
- Product descriptionSR8278 >98%
- Packaging1g
- Price$1900
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number61780
- Product descriptionSR8278
- Packaging10mg
- Price$625
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number61780
- Product descriptionSR8278
- Packaging100mg
- Price$2050
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberS9576
- Product descriptionSR8278 ≥98% (HPLC)
- Packaging5mg
- Price$161
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberS9576
- Product descriptionSR8278 ≥98% (HPLC)
- Packaging25mg
- Price$387.6
- Updated2024-03-01
- Buy
- ManufacturerTocris
- Product number4463
- Product descriptionSR8278 ≥99%(HPLC)
- Packaging10
- Price$195
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number4463
- Product descriptionSR8278 ≥99%(HPLC)
- Packaging50
- Price$818
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 6895DK | CID53393127 | 1mg | $147 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0014157 | SR-8278 95.00% | 10MG | $216.3 | 2021-12-16 | Buy |
| ApexBio Technology | B5606 | SR8278 | 10mg | $229 | 2021-12-16 | Buy |
| Cayman Chemical | 17000 | SR8278 ≥90% | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 17000 | SR8278 ≥90% | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 17000 | SR8278 ≥90% | 10mg | $201 | 2024-03-01 | Buy |
| Cayman Chemical | 17000 | SR8278 ≥90% | 25mg | $443 | 2024-03-01 | Buy |
| DC Chemicals | DC21691 | SR8278 >98% | 100mg | $550 | 2021-12-16 | Buy |
| DC Chemicals | DC21691 | SR8278 >98% | 250mg | $950 | 2021-12-16 | Buy |
| DC Chemicals | DC21691 | SR8278 >98% | 1g | $1900 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 61780 | SR8278 | 10mg | $625 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 61780 | SR8278 | 100mg | $2050 | 2021-12-16 | Buy |
| Sigma-Aldrich | S9576 | SR8278 ≥98% (HPLC) | 5mg | $161 | 2024-03-01 | Buy |
| Sigma-Aldrich | S9576 | SR8278 ≥98% (HPLC) | 25mg | $387.6 | 2024-03-01 | Buy |
| Tocris | 4463 | SR8278 ≥99%(HPLC) | 10 | $195 | 2021-12-16 | Buy |
| Tocris | 4463 | SR8278 ≥99%(HPLC) | 50 | $818 | 2021-12-16 | Buy |
Properties
Melting point :52-55°C
Boiling point :535.7±50.0 °C(Predicted)
Density :1.32±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥30mg/mL
pka :-3.20±0.40(Predicted)
form :film
color :white to tan
Boiling point :535.7±50.0 °C(Predicted)
Density :1.32±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥30mg/mL
pka :-3.20±0.40(Predicted)
form :film
color :white to tan
Safety Information
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Description
REV-ERBα is a nuclear receptor and transcription repressor that coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. SR8278 is an antagonist of REV-ERBα (EC50 = 0.47 μM), blocking activation of the receptor by the synthetic agonist GSK 4112 . Moreover, SR8278 stimulates the expression of two REV-ERBα target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells. SR8278 has been used, with GSK 4112, to elucidate the role of REV-ERBα in regulating glucagon secretion in pancreatic alpha cells.More related product prices
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