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ChemicalBook >> CAS DataBase List >> SU 9516

SU 9516

$29 - $1800
Product name: SU 9516
CAS: 377090-84-1
MF: C13H11N3O2
MW: 241.25
EINECS:
MDL Number:MFCD05865243
Synonyms:(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one;(Z)-3-((1H-iMidazol-4-yl)Methylene)-5-Methoxyindolin-2-one;(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one SU9516;(3Z)-1,3-Dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-2H-indol-2-one;3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one;CS-1784;3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one;SU 9516;SU-9516

Price28 Properties Safety Information Description

28 prices

Selected condition：

Brand

AK Scientific
Ambeed
ApexBio Technology
Cayman Chemical
ChemScene
Crysdot
DC Chemicals
TRC

Package

1mg
5mg
10mg
25mg
50mg
100mg
250mg
500mg
1g

ManufacturerAK Scientific
Product number2734AH
Product description3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one
Packaging1mg
Price$92
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product number2734AH
Product description3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one
Packaging5mg
Price$159
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product number2734AH
Product description3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one
Packaging25mg
Price$386
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA269439
Product descriptionSU9516 98+%
Packaging1mg
Price$29
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA269439
Product descriptionSU9516 98+%
Packaging5mg
Price$58
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA269439
Product descriptionSU9516 98+%
Packaging10mg
Price$75
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA269439
Product descriptionSU9516 98+%
Packaging25mg
Price$98
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA269439
Product descriptionSU9516 98+%
Packaging50mg
Price$128
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA269439
Product descriptionSU9516 98+%
Packaging100mg
Price$167
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA269439
Product descriptionSU9516 98+%
Packaging250mg
Price$333
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA269439
Product descriptionSU9516 98+%
Packaging1g
Price$832
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA4467
Product descriptionSU9516
Packaging10mg
Price$173
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA4467
Product descriptionSU9516
Packaging50mg
Price$677
Updated2021-12-16
Buy

ManufacturerCayman Chemical
Product number14796
Product descriptionSU 9516 ≥98%
Packaging1mg
Price$32
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number14796
Product descriptionSU 9516 ≥98%
Packaging5mg
Price$93
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number14796
Product descriptionSU 9516 ≥98%
Packaging10mg
Price$139
Updated2024-03-01
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
AK Scientific	2734AH	3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one	1mg	$92	2021-12-16	Buy
AK Scientific	2734AH	3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one	5mg	$159	2021-12-16	Buy
AK Scientific	2734AH	3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one	25mg	$386	2021-12-16	Buy
Ambeed	A269439	SU9516 98+%	1mg	$29	2021-12-16	Buy
Ambeed	A269439	SU9516 98+%	5mg	$58	2021-12-16	Buy
Ambeed	A269439	SU9516 98+%	10mg	$75	2021-12-16	Buy
Ambeed	A269439	SU9516 98+%	25mg	$98	2021-12-16	Buy
Ambeed	A269439	SU9516 98+%	50mg	$128	2021-12-16	Buy
Ambeed	A269439	SU9516 98+%	100mg	$167	2021-12-16	Buy
Ambeed	A269439	SU9516 98+%	250mg	$333	2021-12-16	Buy
Ambeed	A269439	SU9516 98+%	1g	$832	2021-12-16	Buy
ApexBio Technology	A4467	SU9516	10mg	$173	2021-12-16	Buy
ApexBio Technology	A4467	SU9516	50mg	$677	2021-12-16	Buy
Cayman Chemical	14796	SU 9516 ≥98%	1mg	$32	2024-03-01	Buy
Cayman Chemical	14796	SU 9516 ≥98%	5mg	$93	2024-03-01	Buy
Cayman Chemical	14796	SU 9516 ≥98%	10mg	$139	2024-03-01	Buy

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Properties

storage temp. :Store at +4°C
solubility :DMSO: ~17 mg/mL
form :crystalline
color :brown

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SU 9516 is a 3-substituted indolinone that has anti-proliferative and pro-apoptotic activity in tumor cells. It is a potent inhibitor of several cyclin-dependent kinases (CDKs) with selectivity for Cdk2 (IC50s = 22, 40, and 200 nM for Cdk2/cyclin A, Cdk1/cyclin B, and Cdk4/cyclin D1). It does not inhibit PKC, p38, PDGFR, or EGFR (IC50’s = >10 μM). SU 9516 inhibits phosphorylation of the retinoblastoma protein pRb, resulting in increased pRb/E2F complex formation, cell-cycle arrest, and subsequent apoptosis. In leukemia cells (U937, Jurkat, and HL-60 cells) SU 9516 downregulates transcription of the antiapoptotic protein Mcl-1, leading to mitochondrial injury and cell death.

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