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ChemicalBook >> CAS DataBase List >> PURVALANOL A

PURVALANOL A

PURVALANOL A price.
  • $22 - $1800
  • Product name: PURVALANOL A
  • CAS: 212844-53-6
  • MF: C19H25ClN6O
  • MW: 388.89
  • EINECS:
  • MDL Number:MFCD02179211
  • Synonyms:PURVALANOL A;NG-60;6-(3-CHLOROANILINO)-2(1R)-ISOPROPYL-2-HYDROXYETHYLAMINO-9-ISOPROPYLPURINE;(2R)-2-[[6-[(3-CHLOROPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL;2-(1R-ISOPROPOYL-2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE;2-(1R-ISOPROPYL-2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYL-PURINE;CH61386;2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanolCDKinhibitor.
43 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Apolloscientific
  • Arctom
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
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  • 100mg
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  • 1g
  • 10mM(in 1mL DMSO)
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-2903-M005
  • Product descriptionPurvalanol A ≥98%(HPLC)
  • Packaging5mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3983AH
  • Product descriptionPurvalanol A
  • Packaging5mg
  • Price$107
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA106338
  • Product descriptionPurvalanol A 98+%
  • Packaging2mg
  • Price$22
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA106338
  • Product descriptionPurvalanol A 98+%
  • Packaging5mg
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA106338
  • Product descriptionPurvalanol A 98+%
  • Packaging10mg
  • Price$38
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA106338
  • Product descriptionPurvalanol A 98+%
  • Packaging50mg
  • Price$112
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA106338
  • Product descriptionPurvalanol A 98+%
  • Packaging100mg
  • Price$212
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA106338
  • Product descriptionPurvalanol A 98+%
  • Packaging250mg
  • Price$351
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA106338
  • Product descriptionPurvalanol A 98+%
  • Packaging1g
  • Price$841
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000205
  • Product descriptionPURVALANOL A 95.00%
  • Packaging1MG
  • Price$160.65
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000205
  • Product descriptionPURVALANOL A 95.00%
  • Packaging10MG
  • Price$745.85
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000205
  • Product descriptionPURVALANOL A 95.00%
  • Packaging50MG
  • Price$1417.71
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4990
  • Product descriptionPurvalanol A
  • Packaging5mg
  • Price$68
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4990
  • Product descriptionPurvalanol A
  • Packaging10mM(in 1mL DMSO)
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4990
  • Product descriptionPurvalanol A
  • Packaging25mg
  • Price$243
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4990
  • Product descriptionPurvalanol A
  • Packaging100mg
  • Price$593
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-2903-M005 Purvalanol A ≥98%(HPLC) 5mg $90 2021-12-16 Buy
AK Scientific 3983AH Purvalanol A 5mg $107 2021-12-16 Buy
Ambeed A106338 Purvalanol A 98+% 2mg $22 2021-12-16 Buy
Ambeed A106338 Purvalanol A 98+% 5mg $28 2021-12-16 Buy
Ambeed A106338 Purvalanol A 98+% 10mg $38 2021-12-16 Buy
Ambeed A106338 Purvalanol A 98+% 50mg $112 2021-12-16 Buy
Ambeed A106338 Purvalanol A 98+% 100mg $212 2021-12-16 Buy
Ambeed A106338 Purvalanol A 98+% 250mg $351 2021-12-16 Buy
Ambeed A106338 Purvalanol A 98+% 1g $841 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000205 PURVALANOL A 95.00% 1MG $160.65 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000205 PURVALANOL A 95.00% 10MG $745.85 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000205 PURVALANOL A 95.00% 50MG $1417.71 2021-12-16 Buy
ApexBio Technology B4990 Purvalanol A 5mg $68 2021-12-16 Buy
ApexBio Technology B4990 Purvalanol A 10mM(in 1mL DMSO) $80 2021-12-16 Buy
ApexBio Technology B4990 Purvalanol A 25mg $243 2021-12-16 Buy
ApexBio Technology B4990 Purvalanol A 100mg $593 2021-12-16 Buy

Properties

Boiling point :590.5±60.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :methylene chloride: 50 mg/mL, clear, colorless
form :powder
pka :14.51±0.10(Predicted)
color :off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively. Purvalanol A reversibly arrests synchronized cells in the G1 and G2 phase of the cell cycle, inhibiting both cell proliferation and cell death. At 10 μM, purvalanol A potently suppresses the anchorage-independent growth of c-Src-transformed cells as well as HT-29 and SW48 human colon cancer cells.

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