TH588
|
- $32 - $3150
- Product name: TH588
- CAS: 1609960-31-7
- MF: C13H12Cl2N4
- MW: 295.17
- EINECS:
- MDL Number:MFCD28963908
- Synonyms:N4-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine;TH588;N4-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine;TH588(TH-588);6-(2,3-dichlorophenyl)-N4-cyclopropylpyrimidine-2,4-diamine;TH 588;TH-588;TH588;CS-1701;TH588, >98%
58 prices
Selected condition：
Brand
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Ark Pharm
- AvaChem
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
Package
- 250mg
- 1.00g
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO
- 5g
- 5
- 25
- 5.00g
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 5mg
- 10mg
- 25MG
- 50mg
- 100MG
- 1G
- 10mM(in1mLDMSO)
- ManufacturerACHEMBLOCK
- Product numberO33860
- Product descriptionTH588 98%
- Packaging25MG
- Price$130
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33860
- Product descriptionTH588 98%
- Packaging100MG
- Price$340
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33860
- Product descriptionTH588 98%
- Packaging1G
- Price$975
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number6084DW
- Product descriptionN~4~-Cyclopropyl-6-(2,3-Dichlorophenyl)pyrimidine-2,4-Diamine
- Packaging1mg
- Price$133
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN5087
- Product descriptionTH588
- Packaging10mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5845
- Product descriptionTH588
- Packaging25mg
- Price$154
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5845
- Product descriptionTH588
- Packaging50mg
- Price$240
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5845
- Product descriptionTH588
- Packaging50mg
- Price$264
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5845
- Product descriptionTH588
- Packaging5mg
- Price$66
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5845
- Product descriptionTH588
- Packaging10mM(in1mLDMSO)
- Price$72
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5845
- Product descriptionTH588
- Packaging100mg
- Price$484
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-12814
- Product descriptionTH588 99.20%
- Packaging100mg
- Price$502
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12814
- Product descriptionTH588 99.20%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$72
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12814
- Product descriptionTH588 99.20%
- Packaging10mM*1mLinDMSO(Solution)
- Price$76
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12814
- Product descriptionTH588 99.20%
- Packaging5mg
- Price$69
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12814
- Product descriptionTH588 99.20%
- Packaging10mg
- Price$95
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | O33860 | TH588 98% | 25MG | $130 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33860 | TH588 98% | 100MG | $340 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33860 | TH588 98% | 1G | $975 | 2026-05-27 | Buy |
| AK Scientific | 6084DW | N~4~-Cyclopropyl-6-(2,3-Dichlorophenyl)pyrimidine-2,4-Diamine | 1mg | $133 | 2021-12-16 | Buy |
| AK Scientific | SYN5087 | TH588 | 10mg | $160 | 2021-12-16 | Buy |
| ApexBio Technology | B5845 | TH588 | 25mg | $154 | 2026-05-06 | Buy |
| ApexBio Technology | B5845 | TH588 | 50mg | $240 | 2021-12-16 | Buy |
| ApexBio Technology | B5845 | TH588 | 50mg | $264 | 2026-05-06 | Buy |
| ApexBio Technology | B5845 | TH588 | 5mg | $66 | 2026-05-06 | Buy |
| ApexBio Technology | B5845 | TH588 | 10mM(in1mLDMSO) | $72 | 2026-05-06 | Buy |
| ApexBio Technology | B5845 | TH588 | 100mg | $484 | 2026-05-06 | Buy |
| Arctom | HY-12814 | TH588 99.20% | 100mg | $502 | 2026-05-26 | Buy |
| Arctom | HY-12814 | TH588 99.20% | 10mM*1mLinDMSO(Solid+Solvent) | $72 | 2026-05-26 | Buy |
| Arctom | HY-12814 | TH588 99.20% | 10mM*1mLinDMSO(Solution) | $76 | 2026-05-26 | Buy |
| Arctom | HY-12814 | TH588 99.20% | 5mg | $69 | 2026-05-26 | Buy |
| Arctom | HY-12814 | TH588 99.20% | 10mg | $95 | 2026-05-26 | Buy |
Properties
Boiling point :545.7±60.0 °C(Predicted)
Density :1.505±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 5 mg/ml).
form :powder
pka :5.90±0.10(Predicted)
color :white to light brown
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C13H12Cl2N4.ClH/c14-9-3-1-2-8(12(9)15)10-6-11(17-7-4-5-7)19-13(16)18-10;/h1-3,6-7H,4-5H2,(H3,16,17,18,19);1H
InChIKey :FBHMEHNWFXCSKE-UHFFFAOYSA-N
SMILES :ClC1=CC=CC(C2=NC(N)=NC(NC3CC3)=C2)=C1Cl.Cl
Density :1.505±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 5 mg/ml).
form :powder
pka :5.90±0.10(Predicted)
color :white to light brown
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C13H12Cl2N4.ClH/c14-9-3-1-2-8(12(9)15)10-6-11(17-7-4-5-7)19-13(16)18-10;/h1-3,6-7H,4-5H2,(H3,16,17,18,19);1H
InChIKey :FBHMEHNWFXCSKE-UHFFFAOYSA-N
SMILES :ClC1=CC=CC(C2=NC(N)=NC(NC3CC3)=C2)=C1Cl.Cl
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
TH588 (1609960-31-7) is a first-in-class nudix hydrolase family inhibitor.1MTH1/NUDT1 is a family member that “sanitizes” oxidized deoxynucleotide triphosphates (dNTP) preventing their incorporation into DNA and thus avoiding DNA damage and cell death. TH588 inhibits MTH1/NUDT1 (IC50= 5 nM) leading to cell death in several cancer cell lines while not affecting normal cells. Activein vitroandin vivo. Recent evidence has raised doubts about the cancer-killing ability of MTH1 inhibition.2,3Conversely, TH588 has been also shown to decrease osteosarcoma cell viability, impair cell cycle, and increase apoptosis via an MTH1-dependent pathway.4More related product prices
Lenvatinib 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- 446859-33-2 Gefitinib Tofacitinib citrate 155148-31-5 N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester TH287 Vorinostat CL 82198 HYDROCHLORIDE ZM 336372 TCPOBOPRelated product price
Suppliers and manufacturers
career henan chemical co
ATK CHEMICAL COMPANY LIMITED
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Coresyn Pharmatech Co., Ltd.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd
Zibo Hangyu Biotechnology Development Co., Ltd
$1.00 /1KG
N4-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine;TH588;N4-cyclopropyl-6-(2,3-dic CAS:1609960-31-7
N4-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine;TH588;N4-cyclopropyl-6-(2,3-dic CAS:1609960-31-7
