TPCA-1
|
- $16 - $1802
- Product name: TPCA-1
- CAS: 507475-17-4
- MF: C12H10FN3O2S
- MW: 279.29
- EINECS:
- MDL Number:MFCD09037541
- Synonyms:TPCA-1;2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide;5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide;TPCA-1(TPCA 1);3-ThiophenecarboxaMide, 2-[(aMinocarbonyl)aMino]-5-(4-fluorophenyl)-;5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide TPCA-1;TPCA-1 IKK-2 Inhibitor IV;GW683965
62 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 0.25mg
- 500μg
- 0.5mg
- 1mg
- 2mg
- 5mg
- 10mg
- 25MG
- 10
- 50mg
- 100mg
- 250mg
- 500mg
- 1g
- 10mM(in1mLDMSO)
- 1000mg
- 10.00g
- 50.00g
- 100.00g
- Manufactureraablocks
- Product numberAA006W2C
- Product descriptionTPCA-1 98+%
- Packaging5mg
- Price$35
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006W2C
- Product descriptionTPCA-1 98+%
- Packaging10mg
- Price$43
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006W2C
- Product descriptionTPCA-1 98+%
- Packaging1mg
- Price$16
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006W2C
- Product descriptionTPCA-1 98%
- Packaging100mg
- Price$207
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006W2C
- Product descriptionTPCA-1 98%
- Packaging250mg
- Price$335
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006W2C
- Product descriptionTPCA-1 98%
- Packaging1g
- Price$935
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberU109926
- Product descriptionTPCA-1 98.00%
- Packaging1G
- Price$1150
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberU109926
- Product descriptionTPCA-1 98.00%
- Packaging100MG
- Price$250
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberU109926
- Product descriptionTPCA-1 98.00%
- Packaging25MG
- Price$110
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX5305
- Product descriptionTPCA-1
- Packaging10mg
- Price$347
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA377370
- Product descriptionTPCA-1 98+%
- Packaging100mg
- Price$443
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA377370
- Product descriptionTPCA-1 98+%
- Packaging250mg
- Price$666
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA377370
- Product descriptionTPCA-1 98+%
- Packaging1g
- Price$1665
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA377370
- Product descriptionTPCA-1 98+%
- Packaging5mg
- Price$59
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA377370
- Product descriptionTPCA-1 98+%
- Packaging50mg
- Price$222
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA377370
- Product descriptionTPCA-1 98+%
- Packaging10mg
- Price$110
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA006W2C | TPCA-1 98+% | 5mg | $35 | 2026-05-28 | Buy |
| aablocks | AA006W2C | TPCA-1 98+% | 10mg | $43 | 2026-05-28 | Buy |
| aablocks | AA006W2C | TPCA-1 98+% | 1mg | $16 | 2026-05-28 | Buy |
| aablocks | AA006W2C | TPCA-1 98% | 100mg | $207 | 2026-05-28 | Buy |
| aablocks | AA006W2C | TPCA-1 98% | 250mg | $335 | 2026-05-28 | Buy |
| aablocks | AA006W2C | TPCA-1 98% | 1g | $935 | 2026-05-28 | Buy |
| ACHEMBLOCK | U109926 | TPCA-1 98.00% | 1G | $1150 | 2026-05-27 | Buy |
| ACHEMBLOCK | U109926 | TPCA-1 98.00% | 100MG | $250 | 2026-05-27 | Buy |
| ACHEMBLOCK | U109926 | TPCA-1 98.00% | 25MG | $110 | 2026-05-27 | Buy |
| AK Scientific | X5305 | TPCA-1 | 10mg | $347 | 2021-12-16 | Buy |
| Ambeed | A377370 | TPCA-1 98+% | 100mg | $443 | 2021-12-16 | Buy |
| Ambeed | A377370 | TPCA-1 98+% | 250mg | $666 | 2021-12-16 | Buy |
| Ambeed | A377370 | TPCA-1 98+% | 1g | $1665 | 2021-12-16 | Buy |
| Ambeed | A377370 | TPCA-1 98+% | 5mg | $59 | 2021-12-16 | Buy |
| Ambeed | A377370 | TPCA-1 98+% | 50mg | $222 | 2021-12-16 | Buy |
| Ambeed | A377370 | TPCA-1 98+% | 10mg | $110 | 2021-12-16 | Buy |
Properties
Melting point :>217°C (dec.)
Boiling point :442.6±45.0 °C(Predicted)
Density :1.490
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear
pka :13.12±0.50(Predicted)
form :powder
color :white to light brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)
InChIKey :SAYGKHKXGCPTLX-UHFFFAOYSA-N
SMILES :NC(=O)Nc1sc(cc1C(N)=O)-c2ccc(F)cc2
Boiling point :442.6±45.0 °C(Predicted)
Density :1.490
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear
pka :13.12±0.50(Predicted)
form :powder
color :white to light brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)
InChIKey :SAYGKHKXGCPTLX-UHFFFAOYSA-N
SMILES :NC(=O)Nc1sc(cc1C(N)=O)-c2ccc(F)cc2
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
TPCA-1 is a selective inhibitor of IκB kinase-2 (IC50s = 17.9 nM and 0.40 μM for IKK2 and IKK1, respectively). Furthermore, it displays greater than 550-fold selectivity over other kinases and enzymes including, p38, MAPK, COX, and JNK. TPCA-1 inhibits the production of LPS-induced TNF-α, IL-6, and IL-8 with IC50 values equal to 0.17, 0.29, and 0.32 μM, respectively. At 20 mg/kg, TPCA-1 has been used to reduce the severity and onset of collagen-induced arthritis in mice and at 30 mg/kg to block cytokine release in an antigen-driven rat model of lung inflammation.Related product price
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Suppliers and manufacturers
3B Pharmachem (Wuhan) International Co.,Ltd.
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Shanghai Topbiochem Technology Co., Ltd
NCE Biomedical Co.,Ltd.
Haoyuan Chemexpress Co., Ltd.
UHN Shanghai Research & Development Co., Ltd.
Shanghai Aladdin Bio-Chem Technology Co.,LTD