Tepotinib
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- $35 - $3772
- Product name: Tepotinib
- CAS: 1100598-32-0
- MF: C29H28N6O2
- MW: 492.57
- EINECS:
- MDL Number:MFCD18452823
- Synonyms:Benzonitrile, 3-[1,6-Dihydro-1-[[3-[5-[(1-Methyl-4-Piperidinyl)Methoxy]-2-PyriMidinyl]Phenyl]Methyl]-6-Oxo-3-Pyridazinyl];3-(1-(3-(5-((1-Methylpiperidin-4-yl)Methoxy)pyriMidin-2-yl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzonitrile;3-(1-(3-(5-((1-METHYLPIPERIDIN-4-YL)METHOXY)PYRIMIDIN-2-YL)BENZYL)-1,6-DIHYDRO-6-OXOPYRIDAZIN-3-YL)B;3-[1,6-Dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]benzonitrile;Tepotinib (EMD 1214063);MSC2156119;3-[1,6-Dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]benzonitrile EMD-1214063;EMD-1214063 3-[1,6-Dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]benzonitrile
50 prices
Selected condition：
Brand
- ACHEMBLOCK
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
Package
- 10mM(1mLinDMSO)
- 10mM*1mLinDMSO(Solution)
- 1mg
- 10.00mg
- 50.00mg
- 100.00mg
- 250mg
- 1000mg
- 10mM(in 1mL DMSO)
- 5MG
- 10mg
- 25MG
- 50mg
- 1G
- 10mM*1mLinDMSO(Solid+Solvent)
- 100MG
- ManufacturerACHEMBLOCK
- Product numberM22536
- Product descriptionEMD1214063 98%
- Packaging5MG
- Price$55
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22536
- Product descriptionEMD1214063 98%
- Packaging25MG
- Price$175
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22536
- Product descriptionEMD1214063 98%
- Packaging100MG
- Price$450
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22536
- Product descriptionEMD1214063 98%
- Packaging1G
- Price$1850
- Updated2026-05-27
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0002572
- Product descriptionEMD-1214063 95.00%
- Packaging5MG
- Price$300.3
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3388
- Product description3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile
- Packaging50mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3388
- Product description3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile
- Packaging100mg
- Price$700
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3388
- Product description3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile
- Packaging10mM(in 1mL DMSO)
- Price$138
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3388
- Product description3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile
- Packaging10mg
- Price$155
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3388
- Product description3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile
- Packaging5mg
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberHY-14721
- Product descriptionTepotinib 99.94%
- Packaging5mg
- Price$126
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-14721
- Product descriptionTepotinib 99.94%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$136
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-14721
- Product descriptionTepotinib 99.94%
- Packaging10mM*1mLinDMSO(Solution)
- Price$136
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-14721
- Product descriptionTepotinib 99.94%
- Packaging10mg
- Price$224
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-14721R
- Product descriptionTepotinib (Standard) 98.44%
- Packaging5mg
- Price$227
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-14721R
- Product descriptionTepotinib (Standard) 98.44%
- Packaging25mg
- Price$722
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | M22536 | EMD1214063 98% | 5MG | $55 | 2026-05-27 | Buy |
| ACHEMBLOCK | M22536 | EMD1214063 98% | 25MG | $175 | 2026-05-27 | Buy |
| ACHEMBLOCK | M22536 | EMD1214063 98% | 100MG | $450 | 2026-05-27 | Buy |
| ACHEMBLOCK | M22536 | EMD1214063 98% | 1G | $1850 | 2026-05-27 | Buy |
| American Custom Chemicals Corporation | KIN0002572 | EMD-1214063 95.00% | 5MG | $300.3 | 2021-12-16 | Buy |
| ApexBio Technology | A3388 | 3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile | 50mg | $400 | 2021-12-16 | Buy |
| ApexBio Technology | A3388 | 3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile | 100mg | $700 | 2021-12-16 | Buy |
| ApexBio Technology | A3388 | 3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile | 10mM(in 1mL DMSO) | $138 | 2021-12-16 | Buy |
| ApexBio Technology | A3388 | 3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile | 10mg | $155 | 2021-12-16 | Buy |
| ApexBio Technology | A3388 | 3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile | 5mg | $105 | 2021-12-16 | Buy |
| Arctom | HY-14721 | Tepotinib 99.94% | 5mg | $126 | 2026-05-26 | Buy |
| Arctom | HY-14721 | Tepotinib 99.94% | 10mM*1mLinDMSO(Solid+Solvent) | $136 | 2026-05-26 | Buy |
| Arctom | HY-14721 | Tepotinib 99.94% | 10mM*1mLinDMSO(Solution) | $136 | 2026-05-26 | Buy |
| Arctom | HY-14721 | Tepotinib 99.94% | 10mg | $224 | 2026-05-26 | Buy |
| Arctom | HY-14721R | Tepotinib (Standard) 98.44% | 5mg | $227 | 2026-05-26 | Buy |
| Arctom | HY-14721R | Tepotinib (Standard) 98.44% | 25mg | $722 | 2026-05-26 | Buy |
Properties
Boiling point :626.5±65.0 °C(Predicted)
Density :1.25
storage temp. :Store at -20°C
form :Solid
pka :8.93±0.10(Predicted)
Appearance :white solid
Water Solubility :≥ 4.93 mg/mL in DMSO, <2.52 mg/mL in EtOH, <2.56 mg/mL in Water
InChIKey :AHYMHWXQRWRBKT-UHFFFAOYSA-N
SMILES :C(#N)C1=CC=CC(C2=NN(CC3=CC=CC(C4=NC=C(OCC5CCN(C)CC5)C=N4)=C3)C(=O)C=C2)=C1
Density :1.25
storage temp. :Store at -20°C
form :Solid
pka :8.93±0.10(Predicted)
Appearance :white solid
Water Solubility :≥ 4.93 mg/mL in DMSO, <2.52 mg/mL in EtOH, <2.56 mg/mL in Water
InChIKey :AHYMHWXQRWRBKT-UHFFFAOYSA-N
SMILES :C(#N)C1=CC=CC(C2=NN(CC3=CC=CC(C4=NC=C(OCC5CCN(C)CC5)C=N4)=C3)C(=O)C=C2)=C1
Safety Information
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| Signal word: | Warning | ||||||||||||||
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| Precautionary statements: |
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Description
MET is a proto-oncogene that encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis. Dysregulation of c-Met occurs in many types of cancer. EMD 1214063 inhibits c-Met with an IC50 value of 3 nM, demonstrating at least 1,000-fold selectivity for c-Met over a panel of 242 additional kinases. It has been shown to inhibit c-Met phosphorylation and downstream signaling in various cancer cell lines (IC50s = 6-9 nM) and, at 5-15 mg/kg, to regress tumors in mouse xenograft models.More related product prices
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