Upadacitinib
|
- $32 - $5000
- Product name: Upadacitinib
- CAS: 1310726-60-3
- MF: C17H19F3N6O
- MW: 380.37
- EINECS:213-161-9
- MDL Number:MFCD30502663
- Synonyms:Upadacitinib;ABT-494(Upadacitinib) free base;ABT-494 (Upadacitinib);Upadacitinib (Rinvoq);ABT-494; ABT494; ABT 494;CS-2730;Upacidatinib;ABT-494
26 prices
Selected condition：
Brand
- AK Scientific
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1g
- 5g
- ManufacturerAK Scientific
- Product number1171DP
- Product descriptionUpadacitinib
- Packaging10mg
- Price$286
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA166721
- Product descriptionABT 494
- Packaging2mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA166721
- Product descriptionABT 494
- Packaging5mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA166721
- Product descriptionABT 494
- Packaging10mg
- Price$700
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA166721
- Product descriptionABT 494
- Packaging50mg
- Price$850
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA166721
- Product descriptionABT 494
- Packaging100mg
- Price$1600
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number29706
- Product descriptionUpadacitinib
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29706
- Product descriptionUpadacitinib
- Packaging5mg
- Price$116
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29706
- Product descriptionUpadacitinib
- Packaging10mg
- Price$169
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29706
- Product descriptionUpadacitinib
- Packaging25mg
- Price$381
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-6150
- Product descriptionUpadacitinib 99.96%
- Packaging5mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6150
- Product descriptionUpadacitinib 99.96%
- Packaging10mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6150
- Product descriptionUpadacitinib 99.96%
- Packaging25mg
- Price$280
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6150
- Product descriptionUpadacitinib 99.96%
- Packaging50mg
- Price$390
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6150
- Product descriptionUpadacitinib 99.96%
- Packaging100mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6150
- Product descriptionUpadacitinib 99.96%
- Packaging200mg
- Price$850
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 1171DP | Upadacitinib | 10mg | $286 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA166721 | ABT 494 | 2mg | $500 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA166721 | ABT 494 | 5mg | $600 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA166721 | ABT 494 | 10mg | $700 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA166721 | ABT 494 | 50mg | $850 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA166721 | ABT 494 | 100mg | $1600 | 2021-12-16 | Buy |
| Cayman Chemical | 29706 | Upadacitinib | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 29706 | Upadacitinib | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 29706 | Upadacitinib | 10mg | $169 | 2024-03-01 | Buy |
| Cayman Chemical | 29706 | Upadacitinib | 25mg | $381 | 2024-03-01 | Buy |
| ChemScene | CS-6150 | Upadacitinib 99.96% | 5mg | $110 | 2021-12-16 | Buy |
| ChemScene | CS-6150 | Upadacitinib 99.96% | 10mg | $160 | 2021-12-16 | Buy |
| ChemScene | CS-6150 | Upadacitinib 99.96% | 25mg | $280 | 2021-12-16 | Buy |
| ChemScene | CS-6150 | Upadacitinib 99.96% | 50mg | $390 | 2021-12-16 | Buy |
| ChemScene | CS-6150 | Upadacitinib 99.96% | 100mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-6150 | Upadacitinib 99.96% | 200mg | $850 | 2021-12-16 | Buy |
Properties
Density :1.56±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:42.67(Max Conc. mg/mL);112.17(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.31(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);78.87(Max Conc. mM)
Ethanol:76.0(Max Conc. mg/mL);199.8(Max Conc. mM) form :A crystalline solid
pka :11.89±0.60(Predicted)
InChI :InChI=1S/C17H19F3N6O/c1-2-10-7-25(16(27)24-9-17(18,19)20)8-11(10)13-5-22-14-6-23-15-12(26(13)14)3-4-21-15/h3-6,10-11,21H,2,7-9H2,1H3,(H,24,27)/t10-,11+/m1/s1
InChIKey :WYQFJHHDOKWSHR-MNOVXSKESA-N
SMILES :N1(C(NCC(F)(F)F)=O)C[C@H](C2N3C4C=CNC=4N=CC3=NC=2)[C@H](CC)C1
storage temp. :Store at -20°C
solubility :DMSO:42.67(Max Conc. mg/mL);112.17(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.31(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);78.87(Max Conc. mM)
Ethanol:76.0(Max Conc. mg/mL);199.8(Max Conc. mM) form :A crystalline solid
pka :11.89±0.60(Predicted)
InChI :InChI=1S/C17H19F3N6O/c1-2-10-7-25(16(27)24-9-17(18,19)20)8-11(10)13-5-22-14-6-23-15-12(26(13)14)3-4-21-15/h3-6,10-11,21H,2,7-9H2,1H3,(H,24,27)/t10-,11+/m1/s1
InChIKey :WYQFJHHDOKWSHR-MNOVXSKESA-N
SMILES :N1(C(NCC(F)(F)F)=O)C[C@H](C2N3C4C=CNC=4N=CC3=NC=2)[C@H](CC)C1
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Upadacitinib is a JAK1 inhibitor (IC50 = 47 nM). It is selective for JAK1 over JAK3 and tyrosine kinase 2 (Tyk2; IC50s = 2,304 and 4,690 nM, respectively), as well as a panel of 83 additional kinases at 1 μM, but does inhibit JAK2, Rho-associated kinase I (ROCK1), and ROCK2 (IC50s = 120, 920, and 430 nM, respectively). Upadacitinib decreases cytokine-induced STAT phosphorylation in a variety of human cells with IC50 values ranging from 1.6 to 649 nM. It reduces M. tuberculosis-induced paw swelling and bone erosion in a rat model of arthritis when administered at doses of 1, 3, and 10 mg/kg twice per day for 17 days. Formulations containing upadacitinib have been used in the treatment of rheumatoid arthritis.More related product prices
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Suppliers and manufacturers
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