2,6,3',5'-四羟基二苯乙烯
中文名称 | 2,6,3',5'-四羟基二苯乙烯 |
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中文同义词 | 2,6,3',5'-四羟基二苯乙烯;买麻藤醇;2,6,3',5'-四羟基二苯乙烯;(E)-2-(3,5-二羟基苯乙烯基)苯-1,3-二酚 |
英文名称 | 2-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,3-benzenediol |
英文同义词 | 2-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,3-benzenediol;Gnetol;2,3',5',6-Tetrahydroxy-trans-stilbene;-2-(3,5-Dihydroxystyryl);2-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol;Gnetol>(E)-2-(3,5-Dihydroxystyryl)benzene-1,3-diol;1,3-Benzenediol, 2-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]- |
CAS号 | 86361-55-9 |
分子式 | C14H12O4 |
分子量 | 244.24 |
EINECS号 | 617-839-9 |
相关类别 | 植物提取物;醇;中药对照品;其它酚类;标准品 -中药标准品;对照品;标准品-对照品;标准品,对照品 |
Mol文件 | 86361-55-9.mol |
结构式 |
2,6,3',5'-四羟基二苯乙烯 性质
熔点 | 271°C(lit.) |
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沸点 | 540.8±30.0 °C(Predicted) |
密度 | 1.468±0.06 g/cm3(Predicted) |
储存条件 | under inert gas (nitrogen or Argon) at 2-8°C |
溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
形态 | 粉末晶体 |
酸度系数(pKa) | 9.06±0.40(Predicted) |
颜色 | 白色至浅黄色至浅橙色 |
最大波长(λmax) | 337nm(EtOH)(lit.) |
CAS 数据库 | 86361-55-9 |
COX-1 0.78 μM (IC 50 ) |
Tyrosinase 4.5 μM (IC 50 ) |
HDAC
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The antiproliferative activities of Gnetol are tested in HCT-116, Hep-G2, MDA-MB-231, and PC-3 cell lines by measuring cell viability after treatment with 4.1 μM, 40.9 μM, 204.7 μM, 409.4 μM, and 1023.6 μM. Gnetol shows concentration-dependent reductions in cell viability in cancer cell lines with greatest activity in colorectal cancer.
Gnetol at 200 µg/mL significantly offers the highest protection of 54.3% against the toxicant. A lower dose of Gnetol (50 µg/mL) also shields the cell line from the toxic effects of CCl4.
The ligand molecule TGF-β and PPARα protein show that Gnetol has the binding affinity of 7.0 and 8.4, respectively.
Male Sprague-Dawley rats were cannulated and dosed either intravenously with Gnetol (10 μg/kg) or orally (100 mg/kg). After oral and intravenous administration, Gnetol is detected in both serum and urine as the parent compound and as a glucuronidated metabolite. The bioavailability of Gnetol is determined to be 6%. Gnetol is rapidly glucuronidated and is excreted in urine and via nonrenal routes.
Pretreatment of Male NIH Swiss mice (20-35 g) with Gnetol (50mg/kg, SC) is able to increase the latency period to response in analgesia models.
安全信息
海关编码 | 2907.29.9000 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-126052 | Gnetol | 1 mg | 900元 | |
2024/08/19 | HY-126052 | 2,6,3',5'-四羟基二苯乙烯 Gnetol | 86361-55-9 | 5mg | 1580元 |