猩红酸钠盐
中文名称 | 猩红酸钠盐 |
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中文同义词 | 6,6'-(1,3-亚脲基)双(1-萘酚-3-磺酸钠);猩红酸钠;猩红酸钠盐;化合物AMI-1;7,7'-(羰基双(氮杂二基))双(4-羟基萘-2-磺酸钠);6,6'-(1,3-亚脲基)双(1-萘酚-3-磺酸钠);AMI 1,可逆蛋白精氨酸甲基转移酶抑制剂;7,7'-(羰基双(氮杂二基))双(4-羟基萘-2-磺酸钠) |
英文名称 | Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) |
英文同义词 | disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonato-2-naphthyl)carbamoylamino]naphthalene-2-sulfonate;disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonato-naphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate;disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate;J acid urea,disodiuM salt 70%;7,7'-(carbonyldiimino)bis(4-hydroxy-2-naphthalenesulfonic acid) disodium salt;Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate);Sodium 6,6'-(1,3-ureylene) bis(1-naphthol-3-sulfonate);Disodium 6,6'-ureylenebis[1-naphthol-3-sulfonate] |
CAS号 | 20324-87-2 |
分子式 | C21H17N2NaO9S2 |
分子量 | 528.48 |
EINECS号 | 243-735-4 |
相关类别 | 小分子抑制剂,天然产物;小分子抑制剂;染料中间体;Inhibitors |
Mol文件 | 20324-87-2.mol |
结构式 |
猩红酸钠盐 性质
储存条件 | under inert gas (nitrogen or Argon) at 2-8°C |
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溶解度 | 不溶于乙醇;不溶于DMSO;水中≥19.1 mg/mL |
形态 | 棕色固体。 |
颜色 | 浅棕色至棕色 |
EPA化学物质信息 | 2-Naphthalenesulfonic acid, 7,7'-(carbonyldiimino)bis[4-hydroxy-, disodium salt (20324-87-2) |
IC50: 8.8 μM (PRMT1), 3.0 μM (yeast-Hmt1p)
AMI-1 can inhibit the in vitro methylation reactions performed by all five recombinantly active PRMTs (PRMT1, -3, -4, and -6 and Hmt1p).
AMI-1 not only inhibits type I PRMTs (PRMT1, 3, 4 and 6) but also type II PRMT5.
AMI-1 specifically inhibits arginine, but not lysine, methyltransferase activity in vitro and does not compete for the AdoMet binding site.
AMI-1 inhibits methylation of GFP-Npl3 and cellular proteins.
AMI-1 (0.6-2.4 mM; 48-96 hours) inhibits the cell viability of sarcoma in S180 and U2OS cells in a time-dependent and dose-dependent manner in vitro.
AMI-1 (1.2-2.4 mM; 48-72 hours) reduces S180 cell viability through the induction of cell apoptosis.
Cell Viability Assay
Cell Line: | S180 cells, U2OS cells |
Concentration: | 0.6 mM, 1.2 mM, 2.4 mM |
Incubation Time: | 48 hours, 72 hours, 96 hours |
Result: | Inhibited the cell viability. |
Apoptosis Analysis
Cell Line: | S180 cells |
Concentration: | 1.2 mM, 2.4 mM |
Incubation Time: | 48 hours, 72 hours |
Result: | Increased the percentages of cells undergoing apoptosis. |
AMI-1 (0.5 mg; intratumorally; daily; for 7 days) inhibits S180 viability in vivo.
AMI-1 (0.5 mg; intratumorally; daily; for 7 days) downregulates PRMT5 but does not regulate the expression of PRMT7 in a tumor xenograft model.
AMI-1 (0.5 mg; intratumorally; daily; for 7 days) decreases the levels of H4R3me2s and H3R8me2s in a tumor xenograft model.
Animal Model: | 6-7 weeks old male Kunming mice (18-22 g), with S180 cells xenograft |
Dosage: | 0.5 mg |
Administration: | Intratumorally, daily, for 7 days |
Result: | Decreased tumor weight. |