盐酸阿地芬宁
| 中文名称 | 盐酸阿地芬宁 |
|---|---|
| 中文同义词 | 解痉素;盐酸二苯胺乙酯;盐酸屈生丁;二苯乙酸 2-(二乙胺基)乙酯;解痉素 盐酸盐;盐酸阿地芬宁(标准品);盐酸阿的芬宁;盐酸阿地芬尼 |
| 英文名称 | Adiphenine hydrochloride |
| 英文同义词 | 2-(Diethylamino)ethyl a-phenylbenzeneacetate hydrochloride;Disodium (6E)-4-amino-3-(4-nitrophenyl)diazenyl-5-oxo-6-(phenylhydrazinylidene)naphthalene-2,7-disulfonate;Oil Black S;Orient Water Black R 455;Spasnil;Spasmolytin;2,2-diphenylacetic acid 2-diethylaminoethyl ester hydrochloride;2-diethylaminoethyl 2,2-diphenylacetate hydrochloride |
| CAS号 | 50-42-0 |
| 分子式 | C20H25NO2.ClH |
| 分子量 | 347.88 |
| EINECS号 | 200-036-9 |
| 相关类别 | 医药原料药;小分子抑制剂;医药原料;原料药;医药与生物化工;其他科研原料药;医药中间体;医药 解痉药;ETHYOL;医药产品;其他原料;医药、农药及染料中间体;医药化工类;医用原料 |
| Mol文件 | 50-42-0.mol |
| 结构式 |  |
盐酸阿地芬宁 性质
| 熔点 | 113-114° |
|---|---|
| 密度 | 1.0555 (rough estimate) |
| 折射率 | 1.5400 (estimate) |
| 储存条件 | Room Temperature |
| 溶解度 | DMSO（微溶）、甲醇（微溶）、水（微溶） |
| 颜色 | 白色 |
| Merck | 14,161 |
| InChIKey | LKPINBXAWIMZCG-UHFFFAOYSA-N |
| CAS 数据库 | 50-42-0(CAS DataBase Reference) |
| Target | Value |
|
α3β4 nAChR
(Cell-free assay) | 1.8 μM |
|
α1 nAChR
(Cell-free assay) | 1.9 μM |
|
α4β2 nAChR
(Cell-free assay) | 3.7 μM |
|
α4β4 nAChR
(Cell-free assay) | 6.3 μM |
Adiphenine (10 nM-1 mM; 3 min) blocks the function of α1*-nAChR in a dose-dependent manner in TE671/RD cells, with an IC
50
of 1.9 µM.
Adiphenine (10 nM-1 mM; 3 min) blocks the function of α3α4*-nAChR in a dose-dependent manner in SH-SY5Y cells, with an IC
50
of 1.8 µM.
Adiphenine (10 nM-1 mM; 3 min) blocks the function of α4β2- and α4β4-nAChR in a dose-dependent manner in SH-EP1 cells, with IC
50
s of 3.7 and 6.3 µM, respectively.
Adiphenine (50-200 µM; 30-60 s) decreases the frequency of ACh-induced single-channel currents in HEK 293 cells.
Adiphenine (i.p.) prevents the hindleg tonic-extensor component of maximal electroshock seizures (MES), with an ED 50 of 62 mg/kg in mice.