盐酸氯哌斯丁
中文名称 | 盐酸氯哌斯丁 |
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中文同义词 | 盐酸氯哌斯汀;盐酸氯哌斯丁;盐酸氯哌丁(咳平);盐酸氯哌斯汀 1KG;氯哌斯汀盐酸盐;咳平盐酸盐;盐酸氯哌丁;CLOPERASTINE HYDROCHLORIDE 氯哌斯汀盐酸盐 |
英文名称 | Cloperastine hydrochloride |
英文同义词 | 1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-piperidinhydrochloride;1-(2-(p-cloro-alpha-fenilbenzilossi)etil)piperidinacloridrato;2-piperidinoethylp-chlorobenzhydryletherhydrochloride;cloperastinacloridrato;ht11;hustazol;4-CHLOROBENZHYDRYL 2-[1-PIPERIDYL]-ETHYL ETHER HYDROCHLORIDE;CHLOPERASTINE HYDROCHLORIDE |
CAS号 | 14984-68-0 |
分子式 | C20H25Cl2NO |
分子量 | 366.32 |
EINECS号 | 239-067-8 |
相关类别 | 医药与生物化工;原料药;分析标准品;法医和兽医标准品;小分子抑制剂;医药原料药;原料;化工原料;医药原料;日用化学品;化学试剂 |
Mol文件 | 14984-68-0.mol |
结构式 |
盐酸氯哌斯丁 性质
熔点 | 147.9° |
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储存条件 | Inert atmosphere,Room Temperature |
溶解度 | 可溶于DMSO(少许)、甲醇(少许) |
颜色 | 白色至类白色 |
Merck | 14,2395 |
CAS 数据库 | 14984-68-0(CAS DataBase Reference) |
27 nM (K + currents)
Cloperastine inhibits the hERG K
+
currents in a concentrationdependent manner with an IC
50
value of 27 nM.
Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.
In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic
action potential (MAP) duration without affecting PR interval or QRS width.
Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD
50
in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively.
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-B2133 | 盐酸氯哌斯丁 Cloperastine hydrochloride | 14984-68-0 | 500mg | 500元 |
2024/01/25 | HY-B2133 | 盐酸氯哌斯丁 Cloperastine hydrochloride | 14984-68-0 | 10mM * 1mLin DMSO | 550元 |