DEHYDROCORYDALINE (CHLORIDE)

DEHYDROCORYDALINE (CHLORIDE)

中文名称DEHYDROCORYDALINE (CHLORIDE)
中文同义词盐酸脱氢紫堇碱, 99.95%;盐酸脱氢紫堇碱;化合物DEHYDROCORYDALINE CHLORIDE;盐酸去氢延胡索碱;盐酸去氢紫堇碱;盐酸脱氢延胡索碱;盐酸脱氢紫堇硷;2,3,9,10-四甲氧基-13-甲基-5,6-二氢异喹啉并[3,2-Α]异喹啉-7-氯化物
英文名称Dehydrocorydaline chloride
英文同义词Dehydrocorydaline chloride;Dehydrocorydaline chloride, 99.95%;13-Methylpalmatine chloride;inhibit,Bcl-2 Family,Dehydrocorydaline chloride,Autophagy,PARP,poly ADP ribose polymerase,Caspase,13-Methylpalmatine,Dehydrocorydaline,p38 MAPK,Parasite,Inhibitor;2,3,9,10-Tetramethoxy-13-methyl-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium chloride
CAS号10605-03-5
分子式C22H24ClNO4
分子量401.88326
EINECS号
相关类别
Mol文件10605-03-5.mol
结构式DEHYDROCORYDALINE (CHLORIDE) 结构式

DEHYDROCORYDALINE (CHLORIDE) 性质

熔点191-193 °C (decomp)
储存条件Store at -20°C
溶解度二甲基亚砜:20mg/mL
形态固体
颜色浅黄至黄色

DEHYDROCORYDALINE (CHLORIDE) 用途与合成方法

Dehydrocorydaline chloride (13-Methylpalmatine chloride) 是从中药延胡索 Corydalis yanhusuo 中分离得到的一种生物碱。Dehydrocorydaline 调节 Bax,Bcl-2 蛋白表达;激活 caspase-7,caspase-8,并使 PARP 失活。Dehydrocorydaline chloride 能增强 p38 MAPK 活化,具有抗炎、抗癌等功效。。Dehydrocorydaline chloride 具有强大的抗疟疾作用,并具低细胞毒性 (细胞生存力> 90%), P. falciparum 3D7 strain (IC50=38 nM)。

p38 MAPK

Treatment of C2C12 myoblasts with 500 nM Dehydrocorydaline increases the expression levels of muscle-specific proteins, including MyoD, myogenin and myosin heavy chain. Treatment with Dehydrocorydaline elevates p38 MAPK activation and the interaction of MyoD with an E protein. Furthermore, defects in differentiation-induced p38 MAPK activation and myoblast differentiation induced by depletion of the promyogenic receptor protein Cdo in C2C12 myoblasts are restored by Dehydrocorydaline treatment. Dehydrocorydaline significantly inhibits MCF-7 cell proliferation in a dose- dependent manner, which can be reversed by a caspase-8 inhibitor, Z-IETD-FMK. Dehydrocorydaline increases DNA fragments without affecting ΔΨm. Western blotting assay shows that dehydrocorydaline dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression. Furthermore, dehydrocorydaline induces activation of caspase-7,-8 and the cleavage of PARP without affecting caspase-9. These results show that dehydrocorydaline inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP.

Dehydrocorydaline (3.6, 6 or 10 mg/kg, i.p.) shows a dose-dependent antinociceptive effect in the acetic acid-induced writhing test and significantly attenuates the formalin-induced pain responses in mice. In the formalin test, dehydrocorydaline decreases the expression of caspase 6 (CASP6), TNF-α, IL-1β and IL-6 proteins in the spinal cord. These findings confirm that Dehydrocorydaline has antinociceptive effects in mice.

安全信息

海关编码2933399990
毒性mouse,LD50,intravenous,9500ug/kg (9.5mg/kg),United States Patent Document. Vol. #3849561,

MSDS信息

更新日期产品编号产品名称CAS号包装价格
2024/08/19HY-N0674ADehydrocorydaline chloride1 mg533元
2024/08/19HY-N0674ADEHYDROCORYDALINE (CHLORIDE)
Dehydrocorydaline chloride
10605-03-55mg1400元

DEHYDROCORYDALINE (CHLORIDE) 上下游产品信息

下游产品
"DEHYDROCORYDALINE (CHLORIDE)"相关产品信息
盐酸万古霉素
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 | 评选活动 | HS海关编码 | MSDS查询 | 化工站点

Copyright © 2016-2023 ChemicalBook 版权所有  京ICP备07040585号  京公海网安备11010802032676号  

互联网增值电信业务经营许可证:京ICP证150597号  互联网药品信息服务资格证编号(京)-非经营性-2015-0073  信息系统安全等级保护备案证明(三级)  营业执照公示

根据相关法律法规和本站规定,单位或个人购买相关危险物品应取得有效的资质、资格条件。
参考《应急管理部等多部门关于加强互联网销售危险化学品安全管理的通知 (应急〔2022〕119号)》《互联网危险物品信息发布管理规定》