DEHYDROCORYDALINE (CHLORIDE)
中文名称 | DEHYDROCORYDALINE (CHLORIDE) |
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中文同义词 | 盐酸脱氢紫堇碱, 99.95%;盐酸脱氢紫堇碱;化合物DEHYDROCORYDALINE CHLORIDE;盐酸去氢延胡索碱;盐酸去氢紫堇碱;盐酸脱氢延胡索碱;盐酸脱氢紫堇硷;2,3,9,10-四甲氧基-13-甲基-5,6-二氢异喹啉并[3,2-Α]异喹啉-7-氯化物 |
英文名称 | Dehydrocorydaline chloride |
英文同义词 | Dehydrocorydaline chloride;Dehydrocorydaline chloride, 99.95%;13-Methylpalmatine chloride;inhibit,Bcl-2 Family,Dehydrocorydaline chloride,Autophagy,PARP,poly ADP ribose polymerase,Caspase,13-Methylpalmatine,Dehydrocorydaline,p38 MAPK,Parasite,Inhibitor;2,3,9,10-Tetramethoxy-13-methyl-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium chloride |
CAS号 | 10605-03-5 |
分子式 | C22H24ClNO4 |
分子量 | 401.88326 |
EINECS号 | |
相关类别 | |
Mol文件 | 10605-03-5.mol |
结构式 |
DEHYDROCORYDALINE (CHLORIDE) 性质
熔点 | 191-193 °C (decomp) |
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储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:20mg/mL |
形态 | 固体 |
颜色 | 浅黄至黄色 |
p38 MAPK
Treatment of C2C12 myoblasts with 500 nM Dehydrocorydaline increases the expression levels of muscle-specific proteins, including MyoD, myogenin and myosin heavy chain. Treatment with Dehydrocorydaline elevates p38 MAPK activation and the interaction of MyoD with an E protein. Furthermore, defects in differentiation-induced p38 MAPK activation and myoblast differentiation induced by depletion of the promyogenic receptor protein Cdo in C2C12 myoblasts are restored by Dehydrocorydaline treatment. Dehydrocorydaline significantly inhibits MCF-7 cell proliferation in a dose- dependent manner, which can be reversed by a caspase-8 inhibitor, Z-IETD-FMK. Dehydrocorydaline increases DNA fragments without affecting ΔΨm. Western blotting assay shows that dehydrocorydaline dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression. Furthermore, dehydrocorydaline induces activation of caspase-7,-8 and the cleavage of PARP without affecting caspase-9. These results show that dehydrocorydaline inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP.
Dehydrocorydaline (3.6, 6 or 10 mg/kg, i.p.) shows a dose-dependent antinociceptive effect in the acetic acid-induced writhing test and significantly attenuates the formalin-induced pain responses in mice. In the formalin test, dehydrocorydaline decreases the expression of caspase 6 (CASP6), TNF-α, IL-1β and IL-6 proteins in the spinal cord. These findings confirm that Dehydrocorydaline has antinociceptive effects in mice.
安全信息
海关编码 | 2933399990 |
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毒性 | mouse,LD50,intravenous,9500ug/kg (9.5mg/kg),United States Patent Document. Vol. #3849561, |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-N0674A | Dehydrocorydaline chloride | 1 mg | 533元 | |
2024/08/19 | HY-N0674A | DEHYDROCORYDALINE (CHLORIDE) Dehydrocorydaline chloride | 10605-03-5 | 5mg | 1400元 |